Results 61 to 70 of about 12,931 (169)

Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. [PDF]

PLoS ONE, 2011
Development of the hematopoietic and endothelial lineages derives from a common mesodermal precursor, the Flk1(+) hemangioblast. However, the signaling pathways that regulate the development of hematopoietic and endothelial cells from this common ...
Xuehui Yang, Yan Gong, Robert Friesel
doaj   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, Volume 117, Issue 4, Page 728-738, October 2026.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Investigating the role of low-level ST6Gal-Ⅰ-mediated CD36 desialylation in ITP based on the MEG-01 cell model

Zhongguo shuxue zazhi
[Objective] To investigate the correlation among α2, 6-sialyltransferase (ST6Gal-Ⅰ), CD36 desialylation, and caveolin-1 (Cav-1) in phorbol ester (PMA)-induced MEG-01 cell model, as well as their potential mechanism in immune thrombocytopenia (ITP ...
FAN Na, ZHONG Lei, LIU Wen, TONG Anqi, LIANG Jing   +4 more
doaj   +1 more source

Activation of Platelet Caspase‐1 and P‐Selectin Over‐Expression in Sickle Cell Disease Patients: An Involvement of NLRP3 Inflammasome?

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Sickle cell disease (SCD) is characterized by hemolytic anaemia, painful vaso‐occlusive crises, and chronic inflammation resulting partly from platelet activation. It has been shown that platelets express the nucleotide‐binding domain leucine‐rich repeat containing protein 3 (NLRP3) and the apoptosis‐associated speck‐like protein containing a ...
Livia Claude, Frédéric Martino, Lydiane Mordier, Doris Célanie, Emmanuelle Bernit, Maryse Etienne‐Julan, Benoît Tressières, Marc Romana, Véronique Baccini   +8 more
wiley   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

Gene expression analysis of embryonic stem cells expressing VE-cadherin (CD144) during endothelial differentiation

BMC Genomics, 2008
Background Endothelial differentiation occurs during normal vascular development in the developing embryo. This process is recapitulated in the adult when endothelial progenitor cells are generated in the bone marrow and can contribute to vascular repair
Libermann Towia, Otu Hasan H, Bhasin Manoj, Nikolova-Krstevski Vesna, Oettgen Peter   +4 more
doaj   +1 more source

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, Volume 4, Issue 3, September 2026.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, Volume 255, Issue 9, Page 896-914, September 2026.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

AUMENTO DA EXPRESSÃO DE CLEC-2 EM AGREGADOS LEUCÓCITO-PLAQUETA E SUA CORRELAÇÃO COM MARCADORES CLÍNICOS E LABORATORIAIS DE GRAVIDADE NA DOENÇA FALCIFORME

Hematology, Transfusion and Cell Therapy
A hipercoagulabilidade é uma característica marcante da doença falciforme (DF), e sua fisiopatologia está associada à ativação simultânea da hemostasia e da imunidade inata, em um processo denominado imunotrombose.
IT Borba-Junior, MS Barbosa, CRP Moraes, LQ Silva, BD Benites, J Annichino-Bizzacchi, FF Costa, EV Paula   +7 more
doaj   +1 more source

ASSOCIATION BETWEEN EXTRACELLULAR VESICLES (EVS) AND THROMBOSIS IN ANTIPHOSPHOLIPID SYNDROME

Hematology, Transfusion and Cell Therapy
Background: Extracellular Vesicles (EVs) are small vesicles derived from activated cells. EVs contain on their surface negatively charged phospholipids, such as phosphatidylserine, as well as active Tissue Factor (TF) and other procoagulant antigens ...
JD Oliveira, BC Robison, BMM Fonseca, FA Orsi   +3 more
doaj   +1 more source