Results 51 to 60 of about 12,931 (169)

Immune platelet transfusion refractoriness associated with anti‐CD36 alloimmunisation in a Brazilian patient with platelet CD36 deficiency

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Immune platelet transfusion refractoriness (PTR) is usually mediated by anti‐HLA class I antibodies; immunisation against CD36 (platelet glycoprotein IV [GPIV]) is relatively rare. Platelet CD36 deficiency shows marked ethnic variability and is seldom reported in admixed Latin American populations.
Rayane Dayse Alves Conserva, Luiz Frederico Bezerra Honorato Junior, Ana Paula Hitomi Yokoyama, Thiago Henrique Costa, Luis Henrique Cardoso Fedeli, Ana Cynira Franco Marret, Eduardo Perez Bastos, Fabio Pires de Souza Santos, Luana Nobrega Costa, Livia Chiosini de Nadai, Carolina Bonet‐Bub, Jose Mauro Kutner   +11 more
wiley   +1 more source

A mouse model of irradiation and spleen-thymus lymphocyte infusion induced aplastic anemia

Hematology, 2022
Objectives The immune-induced aplastic anemia (AA) mouse model has been used for the study of AA. However, there were no uniform conditions for establishing a model and no assessment of immunological homeostasis.
Runfeng Ni, Liwei Fan, Le Zhang, Yanqi Song, Haijin Wang, Aidi Wang, Baoshan Liu   +6 more
doaj   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Tissue‐Specific Isolation of Hepatocyte Extracellular Vesicles From Human Plasma Enables Tissue‐Resolved Proteomic and miRNA Profiling

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
ABSTRACT Tissue‐specific resolution remains a critical barrier in liquid biopsy for precision medicine. To address this, we developed NEXPLOR (Novel EXtracellular vesicle PopuLation Omics Revealer), an immunoaffinity platform enabling selective enrichment of circulating tissue‐specific extracellular vesicles (TS‐EVs), demonstrated here for liver ...
Ricardo Figueiras, Susana Vagueiro, Raissa Kay, Elnaz Persia, Roger de Alwis, Razan Hijazi, Brian Davidson, Kristine von Bargen, Pierre Arsène, Tomás Dias   +9 more
wiley   +1 more source

Flow cytometric kinetic assay of calcium mobilization in whole blood platelets using Fluo‐3 and CD41 [PDF]

Cytometry, 1999
Platelet activation plays a major role in the physiology and pathology of hemostasis. Flow cytometry is a promising approach for the structural and functional analysis of platelets. However, the choice of adequate biological parameters and most technical issues are still under discussion.
M, do Céu Monteiro, F, Sansonetty, M J, Gonçalves, J E, O'Connor   +3 more
openaire   +2 more sources

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

High-Efficiency Enrichment of Megakaryocytes and Identification of Micromegakaryocytes from Human Bone Marrow by Imaging Flow Cytometry

Cells
Megakaryocytes (MKs) are rare, large, polyploid bone marrow (BM) cells responsible for the production of platelets. The identification and characterization of MKs is widely recognized as challenging.
Maya Nautrup Pedersen, Trine Engelbrecht Hybel, Jens Haugbølle Bjerre, Anne Sofie Borg Hammer, Anja Bille Bohn, Marie Bill, Carina Agerbo Rosenberg, Maja Ludvigsen   +7 more
doaj   +1 more source

Release of Intracoronary Microparticles during Stent Implantation into Stable Atherosclerotic Lesions under Protection with an Aspiration Device. [PDF]

PLoS ONE, 2015
Stent implantation into atherosclerotic coronary vessels impacts on downstream microvascular function and induces the release of particulate debris and soluble substances, which differs qualitatively and quantitatively between native right coronary ...
Patrick Horn, Theodor Baars, Philipp Kahlert, Christian Heiss, Ralf Westenfeld, Malte Kelm, Raimund Erbel, Gerd Heusch, Petra Kleinbongard   +8 more
doaj   +1 more source

CD43 but Not CD41 Marks the First Hematopoietic Stem Cells in the Human Embryo

Blood, 2014
Abstract Hematopoietic stem cells (HSCs) emerge during embryogenesis and maintain multilineage hematopoiesis throughout the entire lifespan of the organism. Due to limited access to human embryonic tissues, early human HSC development remains a largely unexplored area of research.
Andrejs Ivanovs, Stanislav Rybtsov, Richard A. Anderson, Alexander Medvinsky   +3 more
openaire   +1 more source

CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis [PDF]

Development, 2008
Development of the vertebrate blood lineages is complex, with multiple waves of hematopoietic precursors arising in different embryonic locations. Monopotent, or primitive, precursors first give rise to embryonic macrophages or erythrocytes. Multipotent, or definitive, precursors are subsequently generated to produce the adult hematopoietic lineages ...
Julien Y, Bertrand, Albert D, Kim, Shutian, Teng, David, Traver   +3 more
openaire   +2 more sources