Results 31 to 40 of about 12,931 (169)

CD41 and CD45 expression marks the angioformative initiation of neovascularisation in human haemangioblastoma

Tumor Biology, 2015
The initiation and formation of haemangioblastoma (HB) neovascularisation remain unknown, with concomitant controversy on its cytological origin. We detected HB-derived specific haematopoietic progenitors identified by surface expression of CD41 and CD45, which are similar to human embryonic vasculogenesis. CD41/CD45 cells expressed mesodermal markers,
Dexuan, Ma, Ying, Wang, Guhong, Du, Jingyun, Yang, Qisheng, Tang, Liangfu, Zhou   +5 more
openaire   +2 more sources

Extracellular Signal-Regulated Kinase Induces the Megakaryocyte GPIIb/CD41 Gene through MafB/Kreisler [PDF]

Molecular and Cellular Biology, 2004
Extracellular signal-regulated kinase (ERK) facilitates cell cycle progression in most mammalian cells, but in certain cell types prolonged signaling through this pathway promotes differentiation and lineage-specific gene expression through mechanisms that are poorly understood.
Joel R, Sevinsky, Anne M, Whalen, Natalie G, Ahn   +2 more
openaire   +2 more sources

Platelets' RNA as biomarker trove for differentiation of early-stage hepatocellular carcinoma from underlying cirrhotic nodules.

PLoS ONE, 2021
Background & aimsAmong the multiplicity of factors involved in rising incidence of hepatocellular carcinoma (HCC)-the second deadliest cancer, late diagnosis of early-stage HCC nodules originating from late-stage cirrhotic nodules is the most crucial. In
Walifa Waqar, Sidra Asghar, Sobia Manzoor   +2 more
doaj   +1 more source

The Dynamic of Extracellular Vesicles in Patients With Subacute Stroke: Results of the “Biomarkers and Perfusion—Training-Induced Changes After Stroke” (BAPTISe) Study

Frontiers in Neurology, 2021
Objective: Extracellular vesicles (EV) are sub-1 μm bilayer lipid coated particles and have been shown play a role in long-term cardiovascular outcome after ischemic stroke.
Ruben A. Jödicke, Ruben A. Jödicke, Shufan Huo, Shufan Huo, Shufan Huo, Nicolle Kränkel, Sophie K. Piper, Sophie K. Piper, Martin Ebinger, Martin Ebinger, Ulf Landmesser, Agnes Flöel, Agnes Flöel, Agnes Flöel, Matthias Endres, Matthias Endres, Matthias Endres, Matthias Endres, Matthias Endres, Alexander H. Nave, Alexander H. Nave, Alexander H. Nave, Alexander H. Nave   +22 more
doaj   +1 more source

Functional activity of platelets and platelet-leukocyte interaction in rheumatoid arthritis: association with subclinical cardiac involvement

Bolʹ, Sustavy, Pozvonočnik
Platelet activation plays a crucial role in the pathogenesis of rheumatoid arthritis (RA) and its associated cardiovascular complications. Assessing platelet functional activity and platelet-leukocyte complexes (PLCs) may help elucidate mechanisms of ...
К.С. Узун, Т.Й. Мальчевська, І.В. Третяк, А.М. Гнилорибов   +3 more
doaj   +1 more source

Direct sequencing of β-globin gene reveals a rare combination of two exonic and two intronic variants in a β-thalassemia major patient: a case report

Journal of Medical Case Reports, 2022
Background Due to indels in the β-globin gene, patients with β-thalassemia major exhibit a range of severity, with genotype β0β0 > β0β+ > β+β+, according to the production level of the β-globin chain. More than 300 mutations have been identified in the β-
Waseem Chauhan, Rafat Fatma, Zeeba Zaka-ur-Rab, Mohammad Afzal   +3 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

EXPRESSION OF CD41 (GPIIB) AND CD61 (GPIIIA) IN PATIENTS WITH GLANZMANN THROMBASTHENIA USING FLOW CYTOMETRY

The Iraqi Journal of Medical Sciences, 2017
Background: Many genetic mutations causing severe reduction or defect in GPIIb (CD41) and/or GPIIIa (CD61) receptors in Glanzmann Thrombasthenia (G.T.).
Hala O. Hassan, Subh S. Al-Mudalal, Yusra G. Alubaidy, Nidal K. Al-Rahal   +3 more
doaj   +6 more sources

Phenotypic and Genotypic Analysis of Two Rare Cases of ‐‐SEA/‐α4.3 HbH Disease

Journal of Clinical Laboratory Analysis, EarlyView.
We report two unrelated adult patients with rare deletional HbH disease (genotype ‐‐SEA/‐α4.3). This novel 4.3 kb deletion covering the HBA1 gene is accompanied by X‐Y‐Z segment recombination, which was identified by CycloneSEQ long‐read nanopore sequencing.
Weijia Yang, Xiaoyan Huang, Li Zhang, Xiaoqin Yang, Yaya Guo, Qingping Kang, Min Dou, Guijun Huang   +7 more
wiley   +1 more source