Results 11 to 20 of about 12,931 (169)

Single-Cell Transcriptomic Profiling Identifies B Cell-Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia. [PDF]

Adv Sci (Weinh)
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Luo D, Zhan Y, Ji L, Xu P, Chen P, Pang H, Ling Y, Hua F, Zhuang X, Chen H, Cheng Y.   +10 more
europepmc   +2 more sources

Dietary CoQ10 Ameliorates Age-Related Megakaryocyte Dysfunction via COPS3-Mediated Activation of Autophagy. [PDF]

Aging Cell
Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Xu Y, Mao YH, Song F, He F, Wu Y, Wang C, Wang M, Xie S, Ni H, Yang Y.   +9 more
europepmc   +2 more sources

CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo [PDF]

Development, 2003
The platelet glycoprotein IIb (αIIb; CD41) constitutes the alpha subunit of a highly expressed platelet surface integrin protein. We demonstrate that CD41 serves as the earliest marker of primitive erythroid progenitor cells in the embryonic day 7 (E7.0) yolk sac and high-level expression identifies essentially all E8.25 yolk sac definitive ...
Michael J, Ferkowicz, Mark, Starr, Xiaodong, Xie, Weiming, Li, Scott A, Johnson, William C, Shelley, Paul R, Morrison, Mervin C, Yoder   +7 more
openaire   +2 more sources

TNFα induces Caspase-3 activity in hematopoietic progenitor cells CD34+, CD33+, and CD41 + of myelodysplastic syndromes

BMC Molecular and Cell Biology, 2023
Background Cytopenia is the primary feature of Myelodysplastic Syndrome, even in the presence of hypercellular bone marrow. TNFα is recognized as both a proinflammatory, and proapoptotic cytokine with a well established role in promoting apoptosis in MDS.
Anggraini Iriani, Andhika Rachman, Rahayuningsih D. Setiabudy, Siti B. Kresno, Aru W. Sudoyo, Mansyur Arief, Alida R. Harahap, Marsya Kaila Fatina   +7 more
doaj   +1 more source

Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output

Cell Reports, 2022
Summary: Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers.
Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, Ute Modlich   +16 more
doaj   +1 more source

The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro

Platelets, 2022
In the clinic, the supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, many scientists have established the derivation of functional platelets from CD34+ cells or human pluripotent stem cells (PSCs).
Weihua Huang, Haihui Gu, Zhiyan Zhan, Ruoru Wang, Lili Song, Yan Zhang, Yingwen Zhang, Shanshan Li, Jinqi Li, Yan Zang, Yanxin Li, Baohua Qian   +11 more
doaj   +1 more source

CD63-positive extracellular vesicles are potential diagnostic biomarkers of pancreatic ductal adenocarcinoma

BMC Gastroenterology, 2022
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest gastrointestinal cancers with a 5-year survival rate of less than 10%. Biomarkers for early PDAC detection are useful in treating patients with PDAC.
Haruki Odaka, Keiko Hiemori, Asako Shimoda, Kazunari Akiyoshi, Hiroaki Tateno   +4 more
doaj   +1 more source

Ruminant cluster CD41/CD61

Veterinary Immunology and Immunopathology, 1996
After analysis of flowcytometry data on bovine and ovine cells and immunoprecipitation studies, a cluster of seven MAbs-CAPP2 (3W-232), IL-Al64 (M430), IL-Al66 (3W-226), IVA30 (3W-069), IVA31 (3W-468), IVA38 (3W-349) and IVA125 (3W528)-was shown to detect bovine and ovine CD41/Cd61 (also known as allS Mateo et al., 1996a). MAb Co-35E4, not submitted to
Mateo, A., Pintado, C.O., Lastra, J.de la, Dusinsky, R., Simon, M., Naessens, Jan, Llanes, D.   +6 more
openaire   +3 more sources

Heterogeneity of the nucleic acid repertoire of plasma extracellular vesicles demonstrated using high-sensitivity fluorescence-activated sorting

Journal of Extracellular Vesicles, 2020
The aim of this study was to investigate cell source-dependent nucleic acids repertoire of diverse subpopulations of plasma extracellular vesicles (EVs). Blood plasma from nine healthy volunteers was used for the analysis. Samples of EVs were obtained by
Kirill Kondratov, Yuri Nikitin, Anton Fedorov, Anna Kostareva, Vladimir Mikhailovskii, Dmitry Isakov, Andrey Ivanov, Alexey Golovkin   +7 more
doaj   +1 more source

CD45 expression discriminates waves of embryonic megakaryocytes in the mouse

Haematologica, 2019
Embryonic megakaryopoiesis starts in the yolk sac on gestational day 7.5 as part of the primitive wave of hematopoiesis, and it continues in the fetal liver when this organ is colonized by hematopoietic progenitors between day 9.5 and 10.5, as the ...
Isabel Cortegano, Natalia Serrano, Carolina Ruiz, Mercedes Rodríguez, Carmen Prado, Mario Alía, Andrés Hidalgo, Eva Cano, Belén de Andrés, María-Luisa Gaspar   +9 more
doaj   +1 more source