Results 121 to 130 of about 139,619 (346)

Another Notch in CD44

The Journal of Cell Biology, 2001
![][1] CD44 can enter and signal in the nucleus. Although the cellular adhesion molecule CD44 is involved in processes ranging from lymphocyte homing to tumor metastasis, it has remained unclear how CD44 transduces the intracellular signals required for such a broad range ...
openaire   +3 more sources

Development of a Sensitive Electrochemical Aptasensor for Non‐Small Cell Lung Cancer Extracellular Vesicle Detection

Advanced Materials Interfaces, EarlyView.
A novel electrochemical aptasensor enables the selective detection of lung cancer‐derived EVs by targeting the CD44 surface marker. The sensor uses a self‐assembled monolayer (SAM) for aptamer immobilization and achieves label‐free EV detection through electrochemical impedance spectroscopy.
Zarinah M. Amin, Volker Nock, Paula Brooksby, Renee V. Goreham   +3 more
wiley   +1 more source

The Association Between Inflammation, Epithelial Mesenchymal Transition and Stemness in Colorectal Carcinoma

Journal of Inflammation Research, 2020
Inese Briede,1 Ilze Strumfa,1 Andrejs Vanags,2 Janis Gardovskis2 1Department of Pathology, Riga Stradins University, Riga, Latvia; 2Department of Surgery, Riga Stradins University, Riga, LatviaCorrespondence: Inese BriedeDepartment of Pathology, Riga ...
Briede I, Strumfa I, Vanags A, Gardovskis J   +3 more
doaj  

Upregulated microRNA‐193a‐3p is responsible for cisplatin resistance in CD44(+) gastric cancer cells

Cancer Science, 2018
Cisplatin is a well‐known anticancer drug used to treat various cancers. However, development of cisplatin resistance has hindered the efficiency of this drug in cancer treatment. Development of chemoresistance is known to involve many signaling pathways.
S. D. Lee, Dayeon Yu, D. Y. Lee, Hyunsoo Shin, J. Jo, Y. Lee   +5 more
semanticscholar   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Synopsis: Special Issue on “Disruption of signaling homeostasis induced crosstalk in the carcinogenesis paradigm Epistemology of the origin of cancer”

4 open, 2019
It is increasingly evident that carcinogenesis, in the vast majority of cancers, cannot be explained simply through an accumulation of somatic mutations, or epigenetics, the stem cell theory, or the Warburg effect.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Understanding miR‐200c: an Important Player in Resistance to Cancer Treatment

Advanced Therapeutics, EarlyView.
How can one microRNA alter cancer's response to therapy? miR‐200c plays a central role in therapeutic resistance by modulating epithelial‐mesenchymal transition, apoptosis, cancer stemness features, and drug efflux. This review outlines the context‐dependent functions of miR‐200c in various cancers and highlights its potential as both a biomarker and a
Fatma Sanli, Omer Faruk Karatas
wiley   +1 more source

Shedding of the CD44 adhesion molecule from leukocytes induced by anti-CD44 monoclonal antibody simulating the effect of a natural receptor ligand. [PDF]

, 1992
V Bažil, Václav Hořejšı́
openalex   +1 more source

Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44

Nature Network Boston, 2010
Cancer stem cells (CSCs), or tumor-initiating cells, are involved in tumor progression and metastasis. MicroRNAs (miRNAs) regulate both normal stem cells and CSCs, and dysregulation of miRNAs has been implicated in tumorigenesis.
Can Liu, K. Kelnar, Bigang Liu, Xin Chen, Tammy Calhoun‐Davis, Hangwen Li, Lubna Patrawala, Hong Yan, Collene R. Jeter, S. Honorio, J. Wiggins, A. Bader, R. Fagin, D. Brown, D. Tang   +14 more
semanticscholar   +1 more source

The LDH‐H3K18La‐Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer

Advanced Science, EarlyView.
Lactate from SCLC tumors induces H3K18 lactylation in naïve CD8+ T cells, upregulating Nurr77 and enhancing tonic TCR signaling. This leads to T cell hyporesponsiveness to stimulation, impairing antitumor immunity and reducing immunotherapy efficacy.
Xiaoling Shang, Bo Cheng, Chenyue Zhang, Chenglong Zhao, Ruiqing Wang, Xun Zhang, Dizhi Jiang, Xinyu Zhang, Xinyue Ma, Hongyuan Mao, Zerun Li, Chenhan Huang, Tianzi Wang, Kaiyue Guo, Liwen Wang, Ning Tang, Haiyong Wang   +16 more
wiley   +1 more source