Results 101 to 110 of about 145,654 (260)

CD133, but Not CD44, May Serve as a Novel Biomarker for Differential Diagnosis Between Basal Cell Carcinoma and Trichoblastomas

Clinical, Cosmetic and Investigational Dermatology, 2022
Yalan Bi,1 Xiaohua Shi,2 Dian Chen,1 Yi Zhao1 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of China; 2Department of Pathology, Peking Union Medical College ...
Bi Y, Shi X, Chen D, Zhao Y
doaj  

CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo

, 2019
Metastasis is responsible for >90% of the deaths of breast cancer patients in the clinic. Here, we report on cross-linked multifunctional hyaluronic acid nanoparticles carrying docetaxel (DTX-CMHN) for enhanced suppression of highly metastatic 4T1 breast
Huanli Sun (1483117), Ru Cheng (1403680), Xiaolei Gu (5578727), Zhiyuan Zhong (1403683), Huimin Fang (707787), Xiaofei Zhao (2129077), Chao Deng (329151)   +6 more
core   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

The role of CD319, CD117, CD28, CD49e, CD56, and CD44 expression as diagnostic and prognostic markers in multiple myeloma

Iraqi Journal of Hematology
BACKGROUND: Multiple myeloma (MM) is a plasma cell disorder characterized by the infiltration of clonal plasma cells in the bone marrow and the detection of a monoclonal immunoglobulin in serum and/or urine.
May Ahmed Al-Ahmed, Haithem Ahmed Al-Rubaie   +1 more
doaj   +1 more source

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

Advanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai, Weikai Sun, Yuxuan Zhao, Daqian Sun, Ting Meng, Yafei Qi, Fengyang Jiang, Jintang Sun, Zhiliang Gao, Dexin Yu   +9 more
wiley   +1 more source

Study of XAV-939 effect on cancer stem cells of human colorectal cancer in heterotopic models in vivo

Якутский медицинский журнал
The purpose of this study was to investigate the numbers of cells with CSC markers in samples of human colorectal cancer (CRC) xenografts isolated in animals with tumors after exposure to the small molecule XAV-939, 5-fluorouracil, and to the combination ...
A. S. Goncharova, G. Yu. Egorov, E. N. Kolesnikov, A. Yu. Maksimov, M. V. Romanova, A. B. Sagakyants, E. S. Bondarenko   +6 more
doaj   +1 more source

CD44 involvement in T1D.

, 2015
Three CD44-dependent pathways affect the fate of T1D in NOD mice. I. CD44 involvement in inflammatory cell migration (blue). Inflammation upregulates CD44 on the islet-infiltrating cells.
Dror Sever (380762), Lora Eshkar Sebban (832332), Pamela Johnson (832328), Itamar Raz (832335), Marika Bogdani (832327), Talya Weiss (832329), Lola Weiss (365487), Nathalie Assayag-Asherie (832326), Sharon Perles (832331), Eva A. Turley (832333), Elimelech Okon (832334), Ariel Ginzberg (832330), David Naor (1905)   +12 more
core   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer

Gut and Liver, 2011
CD44 is a transmembrane glycoprotein and surface receptor for hyaluronan that is involved in the response of cells to their microenvironment. CD44 splice variants play roles in carcinogenesis, differentiation, and lymph node metastasis and are predictive
doaj   +1 more source

The characterization of CD44^high cells and CD44^low cells.

, 2013
A: FACS plots of CD44 positive cells from glial-enriched cellular fraction of P3 mouse cerebellum. There was overlap in the histogram of cell number vs fluorescence intensity of CD44 antibody staining (CD44–PE) between the CD44-positive population and ...
Yasuki Ishizaki (106283), Shuichi Yokoyama (106277), Masashi Kurachi (106280), Masae Naruse (106272), Koji Shibasaki (106274)   +4 more
core   +1 more source