Results 101 to 110 of about 136,526 (307)

The Association Between Inflammation, Epithelial Mesenchymal Transition and Stemness in Colorectal Carcinoma

Journal of Inflammation Research, 2020
Inese Briede,1 Ilze Strumfa,1 Andrejs Vanags,2 Janis Gardovskis2 1Department of Pathology, Riga Stradins University, Riga, Latvia; 2Department of Surgery, Riga Stradins University, Riga, LatviaCorrespondence: Inese BriedeDepartment of Pathology, Riga ...
Briede I, Strumfa I, Vanags A, Gardovskis J   +3 more
doaj  

CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo

, 2019
Metastasis is responsible for >90% of the deaths of breast cancer patients in the clinic. Here, we report on cross-linked multifunctional hyaluronic acid nanoparticles carrying docetaxel (DTX-CMHN) for enhanced suppression of highly metastatic 4T1 breast
Huanli Sun (1483117), Ru Cheng (1403680), Xiaolei Gu (5578727), Zhiyuan Zhong (1403683), Huimin Fang (707787), Xiaofei Zhao (2129077), Chao Deng (329151)   +6 more
core   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

CD44 in rheumatoid arthritis.

Arthritis research & therapy, 2003
CD44 is a multistructural cell-surface glycoprotein that can theoretically generate close to 800 isoforms by differential alternative splicing. At present, several dozen isoforms are known. The polymorphic nature of CD44 might explain its multifunctionality and its ability to interact with many cell-surface and extracellular ligands, the principal one ...
Naor, David, Nedvetzki, Shlomo
openaire   +2 more sources

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Characterisation of apoptotic responses in human keratinocytes expressnig alpha-6 integrin and CD44

, 2010
PhDa6 integrin has previously been proposed as a human keratinocyte stem cell markers. CD44-positive cells in epithelial tumours have been identified as potential cancer stem cells (CSCs) and display increased survival following chemotherapy ...
Wray, Helen
core  

CD44 involvement in T1D.

, 2015
Three CD44-dependent pathways affect the fate of T1D in NOD mice. I. CD44 involvement in inflammatory cell migration (blue). Inflammation upregulates CD44 on the islet-infiltrating cells.
Dror Sever (380762), Lora Eshkar Sebban (832332), Pamela Johnson (832328), Itamar Raz (832335), Marika Bogdani (832327), Talya Weiss (832329), Lola Weiss (365487), Nathalie Assayag-Asherie (832326), Sharon Perles (832331), Eva A. Turley (832333), Elimelech Okon (832334), Ariel Ginzberg (832330), David Naor (1905)   +12 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

The characterization of CD44^high cells and CD44^low cells.

, 2013
A: FACS plots of CD44 positive cells from glial-enriched cellular fraction of P3 mouse cerebellum. There was overlap in the histogram of cell number vs fluorescence intensity of CD44 antibody staining (CD44–PE) between the CD44-positive population and ...
Yasuki Ishizaki (106283), Shuichi Yokoyama (106277), Masashi Kurachi (106280), Masae Naruse (106272), Koji Shibasaki (106274)   +4 more
core   +1 more source