Results 81 to 90 of about 136,526 (307)

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles

Drug Delivery, 2017
The chemotherapy of hematological cancers is challenged by its poor selectivity that leads to low therapeutic efficacy and pronounced adverse effects. Here, we report that doxorubicin encapsulated in lipoic acid-crosslinked hyaluronic acid nanoparticles (
Yinan Zhong, Fenghua Meng, Chao Deng, Xinliang Mao, Zhiyuan Zhong   +4 more
doaj   +1 more source

Stem cell-like circulating tumor cells indicate poor prognosis in gastric cancer

Archives of Medical Science, 2020
Introduction Circulating tumor cells (CTCs) have the characteristics of cancer stem cells and play an important role in the recurrence and metastasis of tumors.
Wang Yi-Wen, Li Long-Long, Lu Ming, Li Hao, Hu Kong-Wang   +4 more
doaj   +1 more source

TGFβ induces invasiveness in the breast cancer cells in a HA-CD44-dependent manner.

, 2019
(A) Representative DIC light microscopy images of 8-day old three-dimensional MDA-MB-231 cell-derived organoids that were left untreated (-) or incubated with different concentrations of LMWHA (100 or 400 μg/mL), without or with 100 pM TGFβ, along with ...
Gregory D. Jay (497394), Ayan Chanda (4020845), Lili Deng (152262), Shirin Bonni (152267), Frank R. Jirik (87132), Suresh C. Regmi (7067324), Kunal Karve (7067327), Anusi Sarkar (7067321), Tannin A. Schmidt (733703)   +8 more
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

CD44 Expression in Papillary Thyroid Carcinoma and its Correlation with Prognostic Factors [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Background and purpose: Identifying the prognostic factors of malignancies is of particular importance in therapeutic decisions and identification of high-risk patients.
Fatemeh Baghertash, Mohammadreza Jalali Nadoushan   +1 more
doaj  

NEAT1 is Required for the Expression of the Liver Cancer Stem Cell Marker CD44 [PDF]

CD44, a cancer stem cell (CSC) marker, is required for maintaining CSC properties in hepatocellular carcinoma (HCC). Nuclear enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), is an oncogenic driver in HCC.
40790374, 00403402, フジワラ, ヨシユキ, ツチヤ, ヒロユキ, Honjo, Soichiro, 40314330, Sakaguchi, Hiromi, 70263457, ホンジョウ, ソウイチロウ, Fujiwara, Yoshiyuki, 26791, 377, 26790, アミサキ, マサタカ, 100000247, 100001755, 100000303, Koyama, Shigemi, 土谷, 博之, Shiota, Goshi, 4866, 95, 網崎, 正孝, シオタ, ゴウシ, 汐田, 剛史, 本城, 総一郎, 藤原, 義之, 780, 100001720, 3368, Tsuchiya, Hiroyuki, Amisaki, Masataka   +31 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

CD44-Targeted Facile Enzymatic Activatable Chitosan Nanoparticles for Efficient Antitumor Therapy and Reversal of Multidrug Resistance

, 2018
Nanoparticles are attractive platforms for the delivery of various anticancer therapeutics. Nevertheless, their applications are still limited by the relatively low drug loading capacity and the occurrence of multidrug resistance (MDR) against ...
Keqi Xiang (4853083), Xiaodong Zhang (183379), Jiajing Zhang (646053), Fan He (303535), Qingsong Yu (1532533), Mingzhi Xu (1517482), Haijia Su (4853077), Zhihua Gan (1532539), Pingping Long (4853080)   +8 more
core   +1 more source

ЭКСПРЕССИЯ МАРКЕРОВ CD44 И CD24 В БИОПСИЙНОМ МАТЕРИАЛЕ БОЛЬНЫХ ТРОЙНЫМ НЕГАТИВНЫМ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ ДО ЛЕЧЕНИЯ

, 2020
The role of the expression of CD44 and CD24 in breast cancer (BC) has been explored in many laboratories around the world to identify predictive markers of tumor aggressiveness and patient’s response to anticancer therapy.
Н. В. Орлова, И. А. Смирнова, S. G. Smirnova, С. Г. Смирнова, I. A. Zamulaeva, И. А. Замулаева, N. V. Orlova, M. V. Kiseleva, A. A. Charitonova, А. А. Харитонова, N. Yu. Dvinskikh, М. В. Киселева, I. A. Smirnova, Н. Ю. Двинских   +13 more
core   +1 more source