Results 61 to 70 of about 136,526 (307)

CD44 Staining of Cancer Stem-Like Cells Is Influenced by Down-Regulation of CD44 Variant Isoforms and Up-Regulation of the Standard CD44 Isoform in the Population of Cells That Have Undergone Epithelial-to-Mesenchymal Transition

, 2013
PMCID: PMC3577706This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Ian C Mackenzie, Luke Gammon (379471), Ian C. Mackenzie (303357), Biddle Adrian, Adrian Biddle, Mackenzie Ian C., Luke Gammon, Fazil Bilal, Bilal Fazil, Biddle, A, Adrian Biddle (379470), Mackenzie, IC, Fazil, B, Gammon, L, Bilal Fazil (379472), Gammon Luke   +15 more
core   +1 more source

The role of CD44 in HNSCC [PDF]

Cancer Biology & Therapy, 2007
Commentary to:Characterization of CD44v3 Containing Isoforms in Head and Neck CancerErika P. Reategui, Adriana Antunez de Mayolo, Parpha M. Das, Frank C. Astor, Rakesh Singal, Kara L. Hamilton, W. Jarrard Goodwin, Kermit L. Carraway and Elizabeth J.
Aaron D, Nelson, Jennifer R, Grandis
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells

Cell Adhesion & Migration, 2019
The role of hyaluronan (HA) in periodontal healing has been speculated via its interaction with the CD44 receptor. While HA-CD44 interactions have previously been implicated in numerous cell types; effect and mechanism of exogenous HA on periodontal ...
Zeinab Al-Rekabi, Adriane M. Fura, Ilsa Juhlin, Alaa Yassin, Tracy E. Popowics, Nathan J. Sniadecki   +5 more
doaj   +1 more source

CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery

, 2016
Hyaluronic acid (HA), which can specifically bind to CD44 receptor, is a specific ligand for targeting to CD44-overexpressing cancer cells. The current study aimed to develop ternary nanoassemblies based on HA-coating for targeted gene delivery to CD44 ...
Jijin Gu (1558708), Xinyi Chen (491760), Xianyi Sha (491764), Xiulei Zhang (2607097), Xiaoling Fang (491763), Xiaoqing Ren (1582708)   +5 more
core   +1 more source

Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer

, 2023
Hematogenous metastasis limits the survival of colorectal cancer (CRC) patients. Here, we illuminated the roles of CD44 isoforms in this process. Isoforms 3 and 4 were predominantly expressed in CRC patients.
Schröder-Schwarz, J, Nersisyan, S, Beine, MC, Freytag, V, Schiecke, A, Haider, MT, Raygorodskaya, M, Novosad, V, Stuke, JL, Elakad, O, Kriegs, M, Bohnenberger, H, Everest-Dass, A, Conradi, LC, Maar, H, et al.   +15 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

The expression of p16, epidermal growth factor receptor and CD44 in squamous cell carcinoma uterine cervix

Indian Journal of Pathology and Microbiology
Cervical cancer is the fourth most common cancer in females in the world, mainly caused by persistent human papilloma virus (HPV) infection. Early diagnosis is important to reduce mortality.
Kanika Gupta, Shramana Mandal, Meeta Singh, Y. M. Mala   +3 more
doaj   +1 more source

Intracellular Domain Fragment of CD44 Alters CD44 Function in Chondrocytes [PDF]

Journal of Biological Chemistry, 2013
The hyaluronan receptor CD44 undergoes sequential proteolytic cleavage at the cell surface. The initial cleavage of the CD44 extracellular domain is followed by a second intramembranous cleavage of the residual CD44 fragment, liberating the C-terminal cytoplasmic tail of CD44. In this study conditions that promote CD44 cleavage resulted in a diminished
Liliana, Mellor, Cheryl B, Knudson, Daisuke, Hida, Emily B, Askew, Warren, Knudson   +4 more
openaire   +2 more sources

CD44-Mediated Methotrexate Delivery by Hyaluronan-Coated Nanoparticles Composed of a Branched Cell-Penetrating Peptide

, 2019
Branched polymers as drug delivery carriers have been widely attempted due to their outstanding drug loading capability and complex stability like branched polyethyleneimine (B-PEI).
Ilkoo Noh (8071985), Sangyong Jon (1343082), Won-Gun Koh (1821514), N. Sanoj Rejinold (5645606), Yeu-Chun Kim (370328), Jisang Yoo (5645609), DaeYong Lee (8195037)   +6 more
core   +1 more source