Results 111 to 120 of about 136,526 (307)
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
International Journal of NanomedicineAbduh MS. Int J Nanomedicine. 2023;18:5713–5732. We, the Editor and Publisher of the journal International Journal of Nanomedicine are retracting the published article.
Abduh MS
doaj
Expression of CD44 and SALL4 in Leukoplakia and Oral Squamous Cell Carcinoma
Journal of Pharmacy and Bioallied SciencesCD44 and SALL4 are markers of stemness and expressed in cancer stem cells (CSCs). Their deregulated expression was seen in various tumors and has been correlated with clinical severity.
Sahoo Pravudeva +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Clinical, Cosmetic and Investigational Dermatology, 2022 Yalan Bi,1 Xiaohua Shi,2 Dian Chen,1 Yi Zhao1 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of China; 2Department of Pathology, Peking Union Medical College ...
Bi Y, Shi X, Chen D, Zhao Y
doaj
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Expression of cancer stem cell marker CD44 and axillary lymph node metastasis in invasive ductal carcinoma of breast [PDF]
Al Ameen Journal of Medical SciencesIntroduction: CD44 is a cell surface transmembrane glycoprotein is a member of cell adhesion molecules responsible for mediating communication and adhesion between adjacent cells and extracellular matrix.
P. Anusha +4 more
doaj
Indian Journal of Pathology and MicrobiologyObjectives: For oral squamous cell carcinoma (OSCC), we are likely at a juncture in clinical management, where the benefits of therapies are beginning to plateau.
Trupti I. Trivedi +2 more
doaj +1 more source
CD44 — a sticky target for asthma [PDF]
Journal of Clinical Investigation, 2003 One of the paradoxes of modern medicine is the rapidly growing incidence of immune-based diseases over the last half of the century (1). Despite enormous advances in our understanding of the immune system, and our ability to manipulate immunity in experimental animals and man, we have not been able to curtail these diseases.
openaire +2 more sources
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source