Results 31 to 40 of about 139,619 (346)

Development a hyaluronic acid ion-pairing liposomal nanoparticle for enhancing anti-glioma efficacy by modulating glioma microenvironment

Drug Delivery, 2018
Glioma, one of the most common brain tumors, remains a challenge worldwide. Due to the specific biological barriers such as blood–brain barrier (BBB), cancer stem cells (CSCs), tumor associated macrophages (TAMs), and vasculogenic mimicry channels (VMs),
Liuqing Yang, Xu Song, Ting Gong, Kejun Jiang, Yingying Hou, Tijia Chen, Xun Sun, Zhirong Zhang, Tao Gong   +8 more
doaj   +1 more source

Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models.

Cancer Discovery, 2018
Circulating tumor cells (CTC) seed cancer metastases; however, the underlying cellular and molecular mechanisms remain unclear. CTC clusters were less frequently detected but more metastatic than single CTCs of patients with triple-negative breast cancer
Xia Liu, Rokana Taftaf, Madoka Kawaguchi, Ya-Fang Chang, Wenjing Chen, D. Entenberg, Youbin Zhang, L. Gerratana, Simo Huang, Dhwani Patel, E. Tsui, Valery Adorno-Cruz, S. Chirieleison, Yue Cao, A. S. Harney, Shivani H. Patel, A. Patsialou, Yang Shen, S. Avril, Hannah Gilmore, J. Lathia, Derek W. Abbott, M. Cristofanilli, J. Condeelis, Huiping Liu   +24 more
semanticscholar   +1 more source

Proteomic analysis of CD44(+) and CD44(−) gastric cancer cells

Molecular and Cellular Biochemistry, 2014
CD44 is a cell surface protein and it is widely used as a cancer stem cell marker in various cancer types including gastric cancer. We conducted proteomic analysis in CD44(+) and CD44(-) gastric cancer cells to understand characteristics of CD44(+) and CD44(-) cells.
Dayeon Yu, Hyun Soo Shin, Go Choi, Yong Chan Lee   +3 more
openaire   +4 more sources

Intracellular Domain Fragment of CD44 Alters CD44 Function in Chondrocytes [PDF]

Journal of Biological Chemistry, 2013
The hyaluronan receptor CD44 undergoes sequential proteolytic cleavage at the cell surface. The initial cleavage of the CD44 extracellular domain is followed by a second intramembranous cleavage of the residual CD44 fragment, liberating the C-terminal cytoplasmic tail of CD44. In this study conditions that promote CD44 cleavage resulted in a diminished
Daisuke Hida, Emily B. Askew, Liliana Mellor, Cheryl B. Knudson, Warren Knudson   +4 more
openaire   +3 more sources

CD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study

Cancer Management and Research, 2021
Cheng Xing, Yatong Li, Cheng Ding, Shunda Wang, Hanyu Zhang, Lixin Chen, Pengyu Li, Menghua Dai Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730,
Xing C, Li Y, Ding C, Wang S, Zhang H, Chen L, Li P, Dai M   +7 more
doaj  

Human breast milk stem cells: a new challenge for perinatologists

Journal of Pediatric and Neonatal Individualized Medicine, 2016
The lactating mammary gland contains a stem cells population with multilineage potentialities. Recently it was also shown that breast milk contains a heterogeneous population of stem cells that have the potential to differentiate in vitro, under the ...
Giuseppina Pichiri, Daniele Lanzano, Monica Piras, Angelica Dessì, Alessandra Reali, Melania Puddu, Antonio Noto, Vassilios Fanos, Carlo Coni, Gavino Faa, Pierpaolo Coni   +10 more
doaj   +1 more source

CD44 Suppression Improved the Chemosensitivity of HT-29 Colorectal Cancer Cells to 5-Fluorouracil and Inhibited Cell Migration [PDF]

Advanced Pharmaceutical Bulletin, 2023
Purpose: CD44 plays a pivotal role through tumorigenesis by regulating cancer cell metastasis, stemness, and chemosensitivity and is considered a promising therapeutic target for human cancers, including colorectal cancer (CRC).
Souzan Najafi, Zohreh Rahimi, Behzad Mansoori, Ali Mohammadi, Fatemeh Mohammadnejad, Mohammad Amini, Ahad Mokhtazadeh, Zahra Asadzadeh, William Chi-Shing Cho, Behzad Baradaran   +9 more
doaj   +1 more source

CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin

Theranostics, 2019
Background: Psoriasis is a common chronic inflammatory skin disease. Its treatment is challenged by the limited amount of drug reaching the inflamed skin.
Yongtai Zhang, Qing Xia, Yanyan Li, Zehui He, Zhe Li, Teng Guo, Zhong-hua Wu, Nianping Feng   +7 more
semanticscholar   +1 more source

CD44: survival and metastasis in chondrosarcoma [PDF]

Osteoarthritis and Cartilage, 2010
Recent studies have shown abnormal expression of CD44s and some of its isoforms in many human malignancies, but little is known about the presence of CD44 in chondrosarcoma. In this study the expression of CD44s and two variant isoforms was evaluated. It was assumed that abnormalities in these receptor proteins may be associated with clinical outcome ...
N. Timmesfeld, Susanne Fuchs-Winkelmann, Markus D. Schofer, R. Moll, J. Wapelhorst, Dominik Malcherczyk, Juergen R J Paletta, Thomas J. Heyse   +7 more
openaire   +3 more sources

Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

Journal of Hematology & Oncology, 2019
BackgroundRing finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 in the progression of melanoma.MethodsWe reanalyzed several gene expression profiles from the Gene Expression Omnibus (GEO ...
Chuanyuan Wei, Mengxuan Zhu, Yan-wen Yang, Peng-fei Zhang, Xuan Yang, Rui Peng, Chao Gao, Jia-Cheng Lu, Lu Wang, Xinyi Deng, Nanhang Lu, F. Qi, Jian-Ying Gu   +12 more
semanticscholar   +1 more source