Results 31 to 40 of about 229,337 (378)

CD44

Journal of biological regulators and homeostatic agents, 2000
Abstract Objective.—To test the hypothesis that CD44 standard (CD44[s]) and its other variants, CD44v6 and CD44v7-8, might be useful markers of squamous differentiation in epithelial tumors. Design.—We studied expression of CD44(s), CD44v6, and CD44v7-8 using immunohistochemistry in human tumors that had squamous ...
Clare M. Isacke, Michael A. Horton
  +5 more sources

Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells

Cancer Research, 2020
These findings establish a mechanistic link between tumor cell CD44, TAM, and CSC properties at the tumor-stroma interface that can serve as a vital area of focus for target and drug discovery.
Karina E Gomez, Fanglong Wu, Stephen B Keysar, J. Morton, Bettina Miller, Tugs-Saikhan Chimed, Phuong N Le, Cera Nieto, Farshad Chowdhury, Anit Tyagi, T. Lyons, C. Young, Hongmei Zhou, H. Somerset, Xiao-Jing Wang, A. Jimeno   +15 more
semanticscholar   +1 more source

DACH1 suppresses breast cancer as a negative regulator of CD44. [PDF]

, 2017
Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for the anti-tumor roles of DACH1 in breast carcinoma are still lack ...
Kuang, Dong, Pestell, Richard, Wu, Kongming, Xiong, Jing, Xu, Hanxiao, Yu, Shengnan, Yuan, Xun   +6 more
core   +2 more sources

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition

Nature Communications, 2020
The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs).
Morgan Oatley, Özge Vargel Bölükbaşi, Valentine Svensson, Maya Shvartsman, Kerstin Ganter, Katharina Zirngibl, Polina V. Pavlovich, Vladislava Milchevskaya, Vladimira Foteva, K. Natarajan, Bianka Baying, V. Beneš, K. Patil, S. Teichmann, Christophe Lancrin   +14 more
semanticscholar   +1 more source

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

Beilstein Journal of Nanotechnology, 2021
Nanomedicine has emerged as a novel cancer treatment and diagnostic modality, whose design constantly evolves towards increasing the safety and efficacy of the chemotherapeutic and diagnostic protocols.
Nikola Geskovski, Nadica Matevska-Geshkovska, Simona Dimchevska Sazdovska, Marija Glavas Dodov, Kristina Mladenovska, Katerina Goracinova   +5 more
doaj   +1 more source

Lack of correlation of stem cell markers in breast cancer stem cells [PDF]

, 2014
BACKGROUND: Various markers are used to identify the unique sub-population of breast cancer cells with stem cell properties. Whether these markers are expressed in all breast cancers, identify the same population of cells, or equate to therapeutic ...
A M Thompson, AM Thompson, C Calabrese, C Ginestier, C Scheel, C Sheridan, CE Eyler, CL Chaffer, CM Fillmore, E Charafe-Jauffret, E Resetkova, EY Tan, F Vaillant, G Farnie, G Kristiansen, G Rappa, H Harrison, H Korkaya, J Stingl, J Zhou, JC Lawson, JM Rosen, K Engelmann, K He, K Murray, M Al-Hajj, M Boylan, M Christgen, M Kok, M Pajic, M V Appleyard, MA Ahmed, ME Prince, MH Wright, MJ Grimshaw, MV Appleyard, O Al-Assar, O Leis, O Moussa, P J Coates, P Kabos, R Nenutil, S Bao, S Liu, SY Kim, SY Park, T Tanei, TM Phillips, WW Hwang-Verslues, Y Liu   +49 more
core   +4 more sources

The biology and role of CD44 in cancer progression: therapeutic implications

Journal of Hematology & Oncology, 2018
CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types including cancer stem cells and frequently shows alternative spliced variants that are thought to play a role in cancer development and progression.
Chen Chen, Shujie Zhao, A. Karnad, J. Freeman   +3 more
semanticscholar   +1 more source

Human prostate sphere-forming cells represent a subset of basal epithelial cells capable of glandular regeneration in vivo. [PDF]

, 2009
BackgroundProstate stem/progenitor cells function in glandular development and maintenance. They may be targets for tumor initiation, so characterization of these cells may have therapeutic implications.
Garraway, Isla P, Goldstein, Andrew S, Hahm, Scott A, Haider, Maahum, Head, Christian S, Perner, Sven, Reiter, Robert E, Rubin, Mark A, Sun, Wenyi, Tran, Chau P, Witte, Owen N, Zhang, Bao   +11 more
core   +1 more source

ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion

Breast Cancer: Targets and Therapy, 2023
Salma M S Ahmad, Hanan Nazar, Md Mizanur Rahman, Radoslaw Stefan Rusyniak, Allal Ouhtit Biological Sciences Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, QatarCorrespondence: Allal ...
Ahmad SMS, Nazar H, Rahman MM, Rusyniak RS, Ouhtit A   +4 more
doaj