Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton [PDF]
, 1999 CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells.
Ursula Günthert +17 more
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Journal of biological regulators and homeostatic agents, 2000 Abstract Objective. —To test the hypothesis that CD44 standard (CD44[s]) and its other variants, CD44v6 and CD44v7-8, might be useful markers of squamous differentiation in epithelial tumors. Design.
Clare M. Isacke, Michael A. Horton
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Regulation of Fas mediated apoptosis by CD44 [PDF]
, 2005 Over the last decade, apoptosis has grown from an obscure process to a complex and interesting scientific field, and many players have been identified.
Mielgo Iza, Ainhoa
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Role of CD44 and its v7 isoform in staphylococcal enterotoxin B-induced toxic shock : CD44 deficiency on hepatic mononuclear cells leads to reduced activation-induced apoptosis that results in increased liver damage [PDF]
, 2005 Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage.
Fisher, M. +11 more
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Chinese Journal of Lung Cancer, 2021 Background and objective Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid growth, early metastasis and acquired therapeutic resistance, and the prognosis is extremely poor.
Ying WANG +9 more
doaj +1 more source
ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion
Breast Cancer: Targets and Therapy, 2023 Salma M S Ahmad, Hanan Nazar, Md Mizanur Rahman, Radoslaw Stefan Rusyniak, Allal Ouhtit Biological Sciences Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, QatarCorrespondence: Allal ...
Ahmad SMS +4 more
doaj
Cells, 2020 Emerging evidence indicates that in myelodysplastic syndromes (MDS), the bone marrow (BM) microenvironment may also contribute to the ineffective, malignant haematopoiesis in addition to the intrinsic abnormalities of haematopoietic stem precursor cells (
Yuenv Wu +8 more
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CD44: a multitude of isoforms with diverse functions. [PDF]
, 1993 The CD44 transmembrane glycoprotein of 90 kD has been known for more than ten years under such diverse designations as lymphocyte homing receptor gp90Hermes, phagocytic glycoprotein Pgp-1, extracellular matrix receptor III (ECMRIII) and hyaluronate ...
Günthert, U., U. Günthert
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Understanding Hyaluronan Receptor (CD44) Interaction, HA-CD44 Activated Potential Targets in Cancer Therapeutics [PDF]
Advanced Pharmaceutical Bulletin, 2021 Cancer is a complex mechanism involving a series of cellular events. The glycoproteins such as hyaluronan (HA) are a significant element of extracellular matrix (ECM), involve in the onset of cancer developmental process.
Gul-e-Saba Chaudhry +5 more
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Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? [PDF]
, 2012 BACKGROUND: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.
James R Smith +11 more
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