Results 31 to 40 of about 118,496 (262)

Expression of CD44 in Tumor Tissue and Serum of Small Cell Lung Cancer and Its Clinical Prognostic Significance

Chinese Journal of Lung Cancer, 2021
Background and objective Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid growth, early metastasis and acquired therapeutic resistance, and the prognosis is extremely poor.
Ying WANG, Yi GUO, Haifeng LIN, Lina ZHANG, Hongmei ZHANG, Qunhui WANG, Fanbin HU, Jie LI, Baolan LI, Tongmei ZHANG   +9 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

FAK Deficiency in Bone Marrow Stromal Cells Alters Their Homeostasis and Drives Abnormal Proliferation and Differentiation of Haematopoietic Stem Cells

Cells, 2020
Emerging evidence indicates that in myelodysplastic syndromes (MDS), the bone marrow (BM) microenvironment may also contribute to the ineffective, malignant haematopoiesis in addition to the intrinsic abnormalities of haematopoietic stem precursor cells (
Yuenv Wu, Lydia Campos, Elisabeth Daguenet, Zhiguo He, Tiphanie Picot, Emmanuelle Tavernier-Tardy, Gilbert Soglu, Denis Guyotat, Carmen-Mariana Aanei   +8 more
doaj   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

A-to-I RNA editing of miR-411 attenuates post-infarction cardiac fibrosis via dual targeting of TGFBR2 and CD44

Zhongguo Linchuang Yixue
ObjectiveTo explore the functional impact of A-to-I editing in the seed region of miR-411 during post-myocardial infarction (MI) fibrosis and elucidate its therapeutic potential.
Suling Ding, Zhiwei Zhang, Xiyang Yang, Dili Sun, Jianfu Zhu, Xiaowei Zhu, Xiangdong Yang, Junbo Ge   +7 more
doaj   +1 more source

Proteomic analysis of CD44(+) and CD44(−) gastric cancer cells

Molecular and Cellular Biochemistry, 2014
CD44 is a cell surface protein and it is widely used as a cancer stem cell marker in various cancer types including gastric cancer. We conducted proteomic analysis in CD44(+) and CD44(-) gastric cancer cells to understand characteristics of CD44(+) and CD44(-) cells.
Dayeon, Yu, Hyun-Soo, Shin, Go, Choi, Yong Chan, Lee   +3 more
openaire   +3 more sources

Hierarchical Collagen Nanofiber Gels Recapitulate a Physiologically Relevant Tumor Stromal Microenvironment

Advanced Healthcare Materials, EarlyView.
The collagen nanofiber (CNF) gel supports cancer cell culture, exhibiting cell morphology and cancer‐related protein expression similar to Matrigel. It offers a higher collagen concentration than commercial gels. Additionally, the CNF gel allows replication of the high elasticity of in vivo cancer tissue by controlling collagen fiber sizes, ranging ...
Naoko Sasaki, Tomoyuki Suezawa, Shiro Kitano, Ryohei Katayama, Michiya Matsusaki   +4 more
wiley   +1 more source

CD133, but Not CD44, May Serve as a Novel Biomarker for Differential Diagnosis Between Basal Cell Carcinoma and Trichoblastomas

Clinical, Cosmetic and Investigational Dermatology, 2022
Yalan Bi,1 Xiaohua Shi,2 Dian Chen,1 Yi Zhao1 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, People’s Republic of China; 2Department of Pathology, Peking Union Medical College ...
Bi Y, Shi X, Chen D, Zhao Y
doaj  

CD44 expression in oral lichen planus and related lesions—An immunohistochemical study

Indian Dermatology Online Journal, 2023
Background: Cluster of differentiation 44 (CD44) is a cell surface adhesion protein involved in the progression and metastasis of oral squamous cell carcinoma.
Muthulakshmi Chandrasekar, Bose Divya, Nandhini Gunasekaran, V Vasanthi, H Nanda Kumar, Krishnan Rajkumar   +5 more
doaj   +1 more source

The role of CD44 in HNSCC [PDF]

Cancer Biology & Therapy, 2007
Commentary to:Characterization of CD44v3 Containing Isoforms in Head and Neck CancerErika P. Reategui, Adriana Antunez de Mayolo, Parpha M. Das, Frank C. Astor, Rakesh Singal, Kara L. Hamilton, W. Jarrard Goodwin, Kermit L. Carraway and Elizabeth J.
Aaron D, Nelson, Jennifer R, Grandis
openaire   +2 more sources