Results 51 to 60 of about 139,619 (346)
CD44 expression in oral lichen planus and related lesions—An immunohistochemical study
Indian Dermatology Online Journal, 2023 Background: Cluster of differentiation 44 (CD44) is a cell surface adhesion protein involved in the progression and metastasis of oral squamous cell carcinoma.
Muthulakshmi Chandrasekar +5 more
doaj +1 more source
Frontiers in Immunology, 2015 The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation, migration, and invasion, which are necessary for inflammation and cancer ...
S. Misra +3 more
semanticscholar +1 more source
Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. [PDF]
The Journal of cell biology, 1996 CD44-mediated cell adhesion to hyaluronate is controlled by mechanisms which are poorly understood. In the present work we examine the role of N-linked glycosylation and Ser-Gly motifs in regulating CD44-hyaluronate interaction. Our results show that treatment of a panel of human cell lines which constitutively express CD44 with the inhibitor of N ...
Armando Bartolazzi +4 more
openaire +3 more sources
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Scientific Reports, 2017 CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same subtype of breast cancer. Systematic comparison of their functions is still lacking.
Wenzhe Li +5 more
semanticscholar +1 more source
A role for CD44 in T cell development and function during direct competition between CD44+ and CD44– cells [PDF]
European Journal of Immunology, 2007 AbstractThe role of CD44 in T cell biology remains incompletely understood. Although studies using anti‐CD44 antibodies have implicated this cell adhesion molecule in a variety of important T cell processes, few T cell defects have been reported in CD44‐deficient mice.
Amanda L. Marzo +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Zaporožskij Medicinskij Žurnal, 2023 The aim of the study is to determine the effect of granulocyte colony-stimulating factor (rHuG-CSF) on the migration of non-resident cells into the region of intracerebral hemorrhage (ICH), which can potentially be considered as mesenchymal stem cells.
A. V. Kuraieva +3 more
doaj +1 more source
CD44 promotes PD-L1 expression and its tumor-intrinsic function in breast and lung cancers.
Cancer Research, 2019 The PD-L1 (CD274) immune checkpoint ligand is often upregulated in cancers to inhibit T cells and elicit immunosuppression. Independent of this activity, PD-L1 has been recently shown to also exert a cancer cell-intrinsic function promoting tumorigenesis.
Tim Kong +17 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source