Results 91 to 100 of about 18,453 (236)
Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment
Small Science, Volume 5, Issue 4, April 2025.Phagocytosis of “apoptotic tumor cells”, known as efferocytosis, accelerates the formation of an immunosuppressive microenvironment, leading to the detriment of tumor therapy. Blocking this process represents one of the novel approaches for treating tumors.
Gangxing Zhu +9 more
wiley +1 more source
Immunometabolism of Liver Xenotransplantation and Prospective Solutions
Advanced Science, Volume 12, Issue 9, March 6, 2025.After xenotransplantation, pig livers will replace those of human patients to maintain the stability of metabolism and immune system. The incompatibility of immunometabolism between humans and pigs induces rejection, inflammation, coagulation dysfunction, and liver failure. The profile of immunometabolism pre‐transplantation and post‐transplantation is
Shoulong Deng +4 more
wiley +1 more source
Scientific Reports, 2018 Autophagy plays a major role in defending against oxidative stress in respiratory epithelial cells. The complement regulatory protein CD46 can enhance autophagy and decrease local complement activation at sites of inflammation.
Y. Tsai +6 more
semanticscholar +1 more source
PLoS ONE, 2015 Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki +4 more
doaj +1 more source
Association of CD46 Cellular Receptor Gene SNP in Measles Vaccine Response
The Iraqi Journal of Medical Sciences, 2020 Background: Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine.
Sarah Al-Gburi +2 more
doaj +1 more source
Advanced Science, Volume 12, Issue 10, March 13, 2025.Immune thrombocytopenia (ITP) is an autoimmune disorder marked by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. It is found that the lectin pathway of the complement system, resistin, MIF, and AA metabolism may serve as promising targets for ...
Jin Li +21 more
wiley +1 more source
The role of human CD46 in early xenoislet engraftment in a dual transplant model
Xenotransplantation, 2019 Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection.
K. Samy +13 more
semanticscholar +1 more source
Regulation of human dendritic cells and T cells by adenovirus vectors types 5 and 35 : implications for vaccine design [PDF]
, 2011 Following viral infection or vaccination dendritic cells (DC) perform an intricate series of roles at the interface of innate and adaptive immunity.
Adams, William C.
core +1 more source
PLoS ONE, 2011 BackgroundAdequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype.
Siobhan Ni Choileain +5 more
doaj +1 more source
Novel blood‐based proteomic signatures across multiple neurodegenerative diseases
Alzheimer's &Dementia, Volume 21, Issue 3, March 2025.Abstract INTRODUCTION Blood‐based biomarkers have the potential to support early and accurate diagnoses of neurodegenerative diseases, which are sensitive to molecular pathology and are predictive of outcome. We evaluated a novel multiplex proteomic method in people with diverse neurodegenerative diseases.
Robert Durcan +15 more
wiley +1 more source