Results 91 to 100 of about 17,628 (245)

Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation?

Frontiers in Immunology, 2017
Viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system.
Walter Fierz
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein [PDF]

, 2015
© 2015 Elsevier Inc.Serum was analyzed from 146 healthy adult volunteers in eastern Africa to evaluate measles virus (MV) and canine distemper virus (CDV) neutralizing antibody (nAb) prevalence and potency.
Allen, S, Anzala, O, Domi, A, Driscoll, J, Fast, P, Gilmour, J, Kamali, A, Karita, E, Parks, CL, Price, MA, Sanders, EJ, Wallace, OL, Wright, KJ, Zhang, X   +13 more
core   +1 more source

Porcine Corneal Tissue and Xenozoonotic Risks: A Review of the Current Evidence

Xenotransplantation, Volume 32, Issue 6, November/December 2025.
ABSTRACT Corneal opacities affect millions worldwide, with corneal transplantation as the primary treatment. However, donor shortages remain a challenge, leaving thousands waiting for transplants. Xenotransplantation using porcine corneas has emerged as a promising alternative due to anatomical and physiological similarities with human corneas ...
Rodrigo Moreira, Heloisa Nascimento, Thaís Maria da Mata Martins, Gabriel Barbieri, Pedro Pires, Lucimeire N. Carvalho, Larissa R. Rosa, Augusto Almeida, Carmen Luz Pessuti, Henrique Ferrer, José Álvaro Pereira Gomes, Ernesto Goulart, Silvano Raia, Rubens Belfort Jr   +13 more
wiley   +1 more source

Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]

, 2019
Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet, Manchala, Nageswar Reddy, Pilankatta, Rajendra, Trivedi, Pankaj, Unniyampurath, Unnikrishnan   +4 more
core   +1 more source

OMICS Analyses in Xenotransplantation: Initial Findings, Key Precautions, and Virus Infections

Xenotransplantation, Volume 32, Issue 6, November/December 2025.
ABSTRACT OMICS analyses have the potential to greatly enhance our understanding of rejection and other processes in xenotransplantation. These approaches may therefore contribute to extending the survival time of xenotransplants. Initial OMICS studies in brain‐dead patients following transplantation of pig kidneys or hearts revealed increased ...
Joachim Denner
wiley   +1 more source

Factor H autoantibody is associated with atypical hemolytic uremic syndrome in children in the United Kingdom and Ireland [PDF]

, 2017
Factor H autoantibodies can impair complement regulation, resulting in atypical hemolytic uremic syndrome, predominantly in childhood. There are no trials investigating treatment, and clinical practice is only informed by retrospective cohort ...
Almond, M, Awan, A, Booth, C, Brocklebank, V, Finlay, E, Fitzpatrick, M, Gilbert, RD, Goodship, TH, Hegde, S, Inward, C, Johnson, S, Kaur, A, Kavanagh, D, Kerecuk, L, Kinoshita, M, Marchbank, KJ, Marks, SD, Salama, AD, Sheerin, NS, Sheerin, TP, Tyerman, K, Walsh, PR, Webb, N, Wong, EKS   +23 more
core   +1 more source

Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies.

PLoS ONE, 2015
Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki, Tia Aalto-Viljakainen, Seppo Meri, Hannele Laivuori, FINNPEC   +4 more
doaj   +1 more source

The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation.

PLoS ONE, 2011
BackgroundAdequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype.
Siobhan Ni Choileain, Nathan J Weyand, Christian Neumann, Joelle Thomas, Magdalene So, Anne L Astier   +5 more
doaj   +1 more source

Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors [PDF]

, 2014
Adenovirus vectors are widely used as vaccine candidates for a variety of pathogens, including HIV-1. To date, human and chimpanzee adenoviruses have been explored in detail as vaccine vectors.
Abbink, Peter, Barouch, Dan H, Blackmore, Stephen, Borducchi, Erica N, Bricault, Christine A, Handley, Scott A, Iampletro, M Justin, Korber, Bette, Maxfield, Lori F, Ng\u27ang\u27a, David, Parenteau, Lily, Teigler, Jeffrey E, Virgin, Herbert W, Wagh, Kshitij, Zhao, Guoyan   +14 more
core   +2 more sources