Results 121 to 130 of about 18,936 (283)
Scientific Reports, 2018 Autophagy plays a major role in defending against oxidative stress in respiratory epithelial cells. The complement regulatory protein CD46 can enhance autophagy and decrease local complement activation at sites of inflammation.
Y. Tsai +6 more
semanticscholar +1 more source
CD46 Contributes to the Severity of Group A Streptococcal Infection [PDF]
Infection and Immunity, 2008 ABSTRACTStreptococcus pyogenes(group AStreptococcus) is a human pathogen that causes a wide variety of diseases ranging from uncomplicated superficial infections to severe infections such as streptococcal toxic shock syndrome and necrotizing fasciitis. These bacteria interact with several host cell receptors, one of which is the cell surface complement
Ann-Beth Jonsson +6 more
openaire +3 more sources
Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43 [PDF]
, 2016 Unique molecular properties of species D adenoviruses (Ads)-the most diverse yet underexplored group of Ads-have been used to develop improved gene vectors. The low seroprevalence in humans of adenovirus serotype 43 (Ad43), an otherwise unstudied species
Amalfitano +54 more
core +1 more source
PLoS ONE, 2015 Preeclampsia is a common disorder of pregnancy characterized by endothelial dysfunction. It may be life-threatening for the mother and fetus in severe cases.
A Inkeri Lokki +4 more
doaj +1 more source
The role of human CD46 in early xenoislet engraftment in a dual transplant model
Xenotransplantation, 2019 Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection.
K. Samy +13 more
semanticscholar +1 more source
PLoS ONE, 2011 BackgroundAdequate termination of an immune response is as important as the induction of an appropriate response. CD46, a regulator of complement activity, promotes T cell activation and differentiation towards a regulatory Tr1 phenotype.
Siobhan Ni Choileain +5 more
doaj +1 more source
Association of CD46 Cellular Receptor Gene SNP in Measles Vaccine Response
The Iraqi Journal of Medical Sciences, 2020 Background: Measles is a highly contagious viral disease. It remains an important cause of death among young children globally, despite the availability of a safe and effective vaccine.
Sarah Al-Gburi +2 more
doaj +1 more source
Obesity, Volume 33, Issue 5, Page 839-850, May 2025.Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Ilja L. Kruglikov, Philipp E. Scherer
wiley +1 more source
Targeting CD46 Enhances Anti-Tumoral Activity of Adenovirus Type 5 for Bladder Cancer
International Journal of Molecular Sciences, 2018 CD46 is generally overexpressed in many human cancers, representing a prime target for CD46-binding adenoviruses (Ads). This could help to overcome low anti-tumoral activity by coxsackie-adenoviral receptor (CAR)-targeting cancer gene therapy viruses ...
Manh-Hung Do +9 more
semanticscholar +1 more source
Asparaginyl endopeptidase (Legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation [PDF]
, 2018 Autocrine activation of the complement receptors C3aR and CD46 by complement activation components C3a and C3b produced through C3 cleavage by the protease cathepsin L (CTSL) during T cell stimulation is a requirement for IFN-γ production and Th1 ...
Claudia Kemper +10 more
core +3 more sources