Results 221 to 230 of about 17,628 (245)

CD46: expanding beyond complement regulation

Trends in Immunology, 2004
During the 1980s CD46 was discovered in a search for C3b binding proteins of human peripheral blood cells. Its role as an inactivator of C3b and C4b deposited on self-tissue is highlighted by the observation that partial deficiency of CD46 is a predisposing factor to hemolytic uremic syndrome.
Rebecca C, Riley-Vargas, Darcy B, Gill, Claudia, Kemper, M Kathryn, Liszewski, John P, Atkinson   +4 more
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CD46: The ‘multitasker’ of complement proteins

The International Journal of Biochemistry & Cell Biology, 2013
Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells.
Yamamoto, Hidekazu; Fara, Antonella Francesca; Dasgupta, Prokar; Kemper, Claudia   +4 more
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Measles Virus and CD46

2008
Measles virus (MV) was isolated in 1954 (Enders and Peeble 1954). It is among the most contagious of viruses and a leading cause of mortality in children in developing countries (Murray and Lopez 1997; Griffin 2001; Bryce et al. 2005). Despite intense research over decades on the biology and pathogenesis of the virus and the successful development in ...
C, Kemper, J P, Atkinson
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Measles virus receptors: SLAM and CD46

Reviews in Medical Virology, 2004
AbstractThe success of vaccination against measles in developed countries has significantly reduced the incidence of measles‐related morbidity and mortality. However, measles is still the leading cause of mortality in children from underdeveloped countries due to low vaccination coverage, high transmissibility of the measles virus as well as primary ...
Neelam, Dhiman, Robert M, Jacobson, Gregory A, Poland   +2 more
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Interaction of Measles Virus (Hallé Strain) with CD46: Evidence That a Common Binding Site on CD46 Facilitates Both CD46 Downregulation and MV Infection

Biochemical and Biophysical Research Communications, 1999
CD46 acts as a cellular receptor for vaccine strains of measles virus (MV). The MV/CD46 interaction-mediated by the MV attachment glycoprotein, the hemagglutinin (H)-not only facilitates infection but also induces CD46 downregulation. A conflict of opinion exists as to whether a single MVH binding site on CD46, or two separate sites, facilitates the ...
V, Lecouturier, A, Rizzitelli, J, Fayolle, L, Daviet, F T, Wild, R, Buckland   +5 more
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Emerging roles and new functions of CD46

Springer Seminars in Immunopathology, 2005
In the past 20 years, our understanding of the workings of complement regulatory protein, CD46 (membrane cofactor protein), has grown as has the impressive list of pathogens interacting with this membrane-bound complement inhibitor. Referred to as a "pathogen magnet," CD46 serves as a receptor for seven human pathogens. Initially discovered as a widely
M Kathryn, Liszewski, Claudia, Kemper, Jeffrey D, Price, John P, Atkinson   +3 more
openaire   +2 more sources

Linking Immune Responses by CD46

Science Signaling, 2002
Marie et al. proposed that the transmembrane glycoprotein CD46, which functions in the activation of complement in the innate immune system, also regulates inflammatory responses of T cells in acquired immunity. CD46 not only binds the C3b and C4b complement products, but is also a receptor for measles and other ...
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Differential downregulation of CD46 by measles virus strains

Journal of Virology, 1995
Recently, we found that several lymphotropic wild-type isolates of measles virus (MV) did not lead to the downregulation of CD46 following infection. We hypothesized that either the site of virus isolation, e.g., throat swab versus peripheral blood mononuclear cells, or the cell type used for the isolation may exert selective pressure on a mixed ...
J, Schneider-Schaulies, L M, Dunster, F, Kobune, B, Rima, V, ter Meulen   +4 more
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CD46, a primate-specific receptor for measles virus

Trends in Microbiology, 1994
Measles virus normally infects only primate cells. The receptor for measles virus has recently been shown to be the complement regulator CD46, also known as membrane cofactor protein. Transfection of rodent cells with human CD46 renders them susceptible to the virus, suggesting that transgenic animals may prove useful for testing antiviral agents and ...
Dörig, R., Marcil, Anne, Richardson, C.
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Virus receptor arrays, CD46 and human herpesvirus 6

Trends in Microbiology, 2000
The discovery of CD46 has now set the stage for studies of HHV-6 pathogenicity, certain features of which are already known. First, the downmodulation of a complement regulatory protein might induce complement activation, and contribute to the damage and clearance of infected cells.
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