Results 61 to 70 of about 18,453 (236)

Complement regulatory protein CD46 promotes bladder cancer metastasis through activation of MMP9

International Journal of Oncology
CD46, a transmembrane protein known for protecting cells from complement-mediated damage, is frequently dysregulated in various types of cancer. Its overexpression in bladder cancers safeguards the cancer cells against both complement and antibody ...
Thuy Thi, Hien Duong Thanh, Van-Tan Nguyen, Se-Young Kwon, Changjong Moon, Eu Chang Hwang, Chaeyong Jung   +6 more
semanticscholar   +1 more source

CD46 facilitates entry and dissemination of human cytomegalovirus

Nature Communications, 2019
Human cytomegalovirus (CMV) causes a wide array of disease to diverse populations of immune-compromised individuals. Thus, a more comprehensive understanding of how CMV enters numerous host cell types is necessary to further delineate the complex nature ...
Kathryn R. Stein, T. Gardner, Rosmely Hernandez, T. Kraus, J. A. Duty, I. Ubarretxena-Belandia, T. Moran, D. Tortorella   +7 more
semanticscholar   +1 more source

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome [PDF]

, 2014
Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment.
Goodship, T, Scully, M
core   +1 more source

A Human In Vitro Model to Study Adenoviral Receptors and Virus Cell Interactions

Cells, 2022
To develop adenoviral cell- or tissue-specific gene delivery, understanding of the infection mechanisms of adenoviruses is crucial. Several adenoviral attachment proteins such as CD46, CAR and sialic acid have been identified and studied.
Raphael L. Tsoukas, Wolfram Volkwein, Jian Gao, Maren Schiwon, Nora Bahlmann, Thomas Dittmar, Claudia Hagedorn, Eric Ehrke-Schulz, Wenli Zhang, Armin Baiker, Anja Ehrhardt   +10 more
doaj   +1 more source

Dysregulation of mCD46 and sCD46 contribute to the pathogenesis of bullous pemphigoid

Scientific Reports, 2017
Bullous pemphigoid (BP) is an autoimmune bullous disease caused by autoantibodies against BP180 in the epidermal basement membrane. Autoantibody-mediated complement activation is an important process in BP pathogenesis.
Pei Qiao, Erle Dang, Tianyu Cao, Hui Fang, Jieyu Zhang, Hongjiang Qiao, Gang Wang   +6 more
doaj   +1 more source

CD46 splice variant enhances translation of specific mRNAs linked to an aggressive tumor cell phenotype in bladder cancer

Molecular Therapy: Nucleic Acids, 2021
CD46 is well known to be involved in diverse biological processes. Although several splice variants of CD46 have been identified, little is known about the contribution of alternative splicing to its tumorigenic functions.
Jin Zeng, Hua Xu, Chunhua Huang, Yi Sun, Haibing Xiao, Gan Yu, Hui Zhou, Yangjun Zhang, Weimin Yao, Wei Xiao, Junhui Hu, Lily Wu, Jinchun Xing, Tao Wang, Zhiqiang Chen, Zhangqun Ye, Ke Chen   +16 more
doaj  

Automaton-based parsing for lexicalized grammars [PDF]

, 1997
In wide-coverage lexicalized grammars many of the elementary structures have substructures in common. This means that during parsing some of the computation associated with different structures is duplicated. This paper explores ways in which the grammar
Evans, Roger, Weir, David
core   +2 more sources

The Reorientation of T-Cell Polarity and Inhibition of Immunological Synapse Formation by CD46 Involves Its Recruitment to Lipid Rafts [PDF]

, 2011
Many infectious agents utilize CD46 for infection of human cells, and therapeutic applications of CD46-binding viruses are now being explored. Besides mediating internalization to enable infection, binding to CD46 can directly alter immune function.
Christansen, Dale, Crimeen-Irwin, Blessing, Gaus, Katharina, Guillaumot, Patricia, Ludford-Menting, Mandy J., Manie, Serge, Oliaro, Jane, Pasam, Anupama, Pedersen, Natalie, Russell, Sarah M., Williamson, David   +10 more
core   +4 more sources

Complement regulatory proteins: Candidate biomarkers in differentiating tuberculosis pleural effusion

Frontiers in Immunology, 2023
Background and aimsComplement activation is essential for tuberculosis pleural effusion. However, little is known about the value of complement regulatory protein (CD46, CD55, and CD59) in the differential diagnosis of tuberculosis.Materials and ...
Huan Tang, Huan Tang, Xinyue Hu, Xinyue Hu, Li Li, Shuanglinzi Deng, Shuanglinzi Deng, Yuanyuan Jiang, Yuanyuan Jiang, Lisha Luo, Lisha Luo, Runjin Cai, Runjin Cai, Yifei Yang, Yifei Yang, Chendong Wu, Chendong Wu, Xiaoxiao Gong, Xiaoxiao Gong, Juntao Feng, Juntao Feng   +20 more
doaj   +1 more source

Colon‐targeted complement C5a1 receptor inhibition using pH‐sensitive nanoparticles ameliorates experimental colitis

British Journal of Pharmacology, EarlyView.
Background and Purpose The complement system is associated with inflammatory bowel disease (IBD) pathology. Complement activation induces C5a production, which signals through the C5a1 receptor (C5aR1) to drive inflammatory responses that may underlie IBD.
Cedric S. Cui, Titaya Lerskiatiphanich, Xaria X. Li, Rabina Giri, Ning Liu, Vinod Kumar, Andrew K. Whittaker, Felicity Y. Han, Richard J. Clark, Jakob Begun, John D. Lee, Trent M. Woodruff   +11 more
wiley   +1 more source