Results 81 to 90 of about 18,453 (236)

Identification of autophagy-related risk signatures for the prognosis, diagnosis, and targeted therapy in cervical cancer

Cancer Cell International, 2021
Background To rummage autophagy-related prognostic, diagnostic, and therapeutic biomarkers in cervical cancer (CC). Methods The RNA-sequence and clinical information were from the TCGA and GTEx databases.
Dan Meng, Hua Jin, Xing Zhang, Wenjing Yan, Qianqian Xia, Siyuan Shen, Shuqian Xie, Mengjing Cui, Bo Ding, Yun Gu, Shizhi Wang   +10 more
doaj   +1 more source

Efficient generation of vesicular stomatitis virus (VSV)-pseudotypes bearing morbilliviral glycoproteins and their use in quantifying virus neutralising antibodies [PDF]

, 2016
Morbillivirus neutralising antibodies are traditionally measured using either plaque reduction neutralisation tests (PRNTs) or live virus microneutralisation tests (micro-NTs).
Adombi, Alexander, Angharad A. Drew, Appel, Banyard, Banyard, Barrett, Bieringer, Brian J. Willett, Bussell, Carpenter, Daniel T. Haydon, de Swart, de Swart, de Swart, de Vries, Dorig, Drexler, Elizabeth McMonagle, Emi Takahashi, Erlenhoefer, Frecha, Gillespie, Goldstein, Graham, Harder, Hsu, Hu, Hvistendahl, Lloyd-Smith, Lorenz, Mamaev, Margaret J. Hosie, Martin Gilbert, Mather, Michael D. Baron, Michael McDonald, Munir, Naldini, Naniche, Nicola Logan, Noyce, Noyce, Noyce, Origgi, Pratakpiriya, Qiu, Rima, Roelke-Parker, Sakai, Sakai, Sarah Cleaveland, Sato, Seimon, Seki, Sun, Tahara, Tahara, Takada, Tatsuo, Tatsuo, Terio, van de Bildt, von Messling, Whitt, Williams, Yasumura, Yoshikawa, Zhang   +68 more
core   +2 more sources

Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer.

JCI Insight, 2018
Although initially responsive to androgen signaling inhibitors (ASIs), metastatic castration-resistant prostate cancer (mCRPC) inevitably develops and is incurable.
Yang Su, Yue Liu, Christopher Behrens, S. Bidlingmaier, Nam-Kyung Lee, R. Aggarwal, Daniel W. Sherbenou, A. Burlingame, B. Hann, J. Simko, Gayatri Premasekharan, P. Paris, M. Shuman, Youngho Seo, E. Small, B. Liu   +15 more
semanticscholar   +1 more source

Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells.

PLoS ONE, 2012
Cell microparticles (MPs) released in the extracellular milieu can embark plasma membrane and intracellular components which are specific of their cellular origin, and transfer them to target cells.
Gaëlle Gonzalez, Cyrielle Vituret, Attilio Di Pietro, Marc Chanson, Pierre Boulanger, Saw-See Hong   +5 more
doaj   +1 more source

Alteration of membrane complement regulators is associated with transporter status in patients on peritoneal dialysis. [PDF]

PLoS ONE, 2017
INTRODUCTION:A growing body of evidence from animal models and cell culture studies indicate an important role of a local regulatory complement system (CS) in peritoneal injury during peritoneal dialysis (PD).
Daniel Kitterer, Dagmar Biegger, Stephan Segerer, Niko Braun, M Dominik Alscher, Joerg Latus   +5 more
doaj   +1 more source

Regulation of the terminal complement cascade in adipose tissue for control of its volume, cellularity, and fibrosis

Obesity, Volume 33, Issue 5, Page 839-850, May 2025.
Abstract White adipose tissue (WAT) is a reservoir for various pathogens and their products, such as lipopolysaccharides. Therefore, it must be equipped with a defense mechanism connected with the activation of innate immunity. This explains the phenomenon that adipocytes express components of the classical and alternative complement pathways, which ...
Ilja L. Kruglikov, Philipp E. Scherer
wiley   +1 more source

CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae [PDF]

, 2002
The Neisseria type IV pilus promotes bacterial adhesion to host cells. The pilus binds CD46, a complement-regulatory glycoprotein present on nucleated human cells (Källström et al., 1997).
Atkinson, John P., Bonnah, Robert A., Higashi, Dustin L., Lee, Shaun W., Milgram, Sharon L., So, Magdalene   +5 more
core   +4 more sources

Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This review article delves into the cutting‐edge advancements in gene editing technology, with a particular focus on prime editor proteins and their engineered variants. The authors provide a thorough examination of recent developments that have addressed key challenges in the field, including improved precision, enhanced editing efficiency, and ...
Abhijith Koodamvetty, Saravanabhavan Thangavel   +1 more
wiley   +1 more source

Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes

PLoS Pathogens, 2019
The Gram-negative human pathogen N. gonorrhoeae (Ngo) quickly attaches to epithelial cells, and large numbers of the bacteria remain on the cell surface for prolonged periods.
Won J Kim, Annette Mai, N. Weyand, María A. Rendón, Koenraad van Doorslaer, Magdalene So   +5 more
semanticscholar   +1 more source

Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation?

Frontiers in Immunology, 2017
Viruses are able to interfere with the immune system by docking to receptors on host cells that are important for proper functioning of the immune system.
Walter Fierz
doaj   +1 more source