Results 21 to 30 of about 20,247 (196)
The application of HER2 and CD47 CAR-macrophage in ovarian cancer
Journal of Translational Medicine, 2023 Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the limited CAR-T cell infiltration into solid tumors and the inactivation of CAR-T cells by the immunosuppressive tumor microenvironment ...
Yizhao Chen +17 more
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Animal Cells and Systems, 2020 CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy.
Pascal Leclair, Chinten James Lim
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Nature Communications, 2020 Professional antigen presenting cells (APCs) are deterred from phagocytosing cancer cells that express CD47. Here, the authors show that in glioblastoma mouse models, temozolomide improves the phagocytosis effect of CD47 blockade in APCs and results in ...
Christina A. von Roemeling +17 more
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Upregulation of CD47 Is a Host Checkpoint Response to Pathogen Recognition
mBio, 2020 It is well understood that the adaptive immune response to infectious agents includes a modulating suppressive component as well as an activating component. We now show that the very early innate response also has an immunosuppressive component. Infected
Michal Caspi Tal +36 more
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219 CD47 and phosphatidylserine contribute to the interaction between antigen presenting cells and the allogeneic cell-based relapse vaccine DCP-001 [PDF]
Regular and Young Investigator Award Abstracts, 2021 Background DCP-001 is a cancer relapse vaccine derived from the DCOne® human leukemic cell line. During manufacturing, DCOne® cells are shifted towards a mature dendritic cell (mDC) phenotype, combining an endogenous tumor antigen repertoire (e.g.
Haoxiao Zuo +10 more
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Frontiers in Immunology, 2022 Antibody-dependent cellular phagocytosis (ADCP) by macrophages, an important effector function of tumor targeting antibodies, is hampered by ‘Don´t Eat Me!’ signals such as CD47 expressed by cancer cells.
Tobias Zeller +28 more
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Preclinical efficacy and toxicity studies of a highly specific chimeric anti‐CD47 antibody
FEBS Open Bio, 2021 Cluster of differentiation 47 (CD47) is a widely expressed self‐protection transmembrane protein that functions as a critical negative regulator to induce macrophage‐mediated phagocytosis.
Zhiqiang Xu +6 more
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PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47) [PDF]
Scientific Reports, 2019 AbstractMalaria symptoms and pathology are initiated by invasion of host erythrocytes by Plasmodium merozoites in a complex process that involves interactions between parasite and host erythrocyte proteins. Erythrocyte invasion presents attractive targets for malaria vaccine and drug development.
Hikaru Nagaoka +10 more
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The landscape overview of CD47-based immunotherapy for hematological malignancies
Biomarker Research, 2023 Extensive clinical and experimental evidence suggests that macrophages play a crucial role in cancer immunotherapy. Cluster of differentiation (CD) 47, which is found on both healthy and malignant cells, regulates macrophage-mediated phagocytosis by ...
Hua Yang, Yang Xun, Hua You
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Novel CD47: SIRPα Dependent Mechanism for the Activation of STAT3 in Antigen-Presenting Cell
PLoS ONE, 2013 Cell surface CD47 interacts with its receptor, signal-regulatory-protein α (SIRPα) that is expressed predominantly on macrophages, to inhibit phagocytosis of normal, healthy cells. This "don't eat me" signal is mediated through tyrosine phosphorylation of SIRPα at the cytoplasmic ITIM motifs and the recruitment of the phosphatase, SHP-1.
Natan Toledano +3 more
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