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Cytokine-induced killer (CIK) cells are in-vitro-expanded T lymphocytes that represent a heterogeneous population. A large majority of CIK cells are CD3(+)CD56(+), and this population has been shown to confer a cytotoxic effect against tumor targets.
Valgardsdottir, Rut +8 more
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Human NK cells responses are enhanced by CD56 engagement
Natural Killer (NK) cells are important innate lymphocytes for effective immune responses against intracellular pathogens and tumors. CD56 is a well-known marker for human NK cells, but there is very limited information about a functional role of this ...
Carsten Watzl, Maren Claus
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CD4+ CD56+ Hematodermic Neoplasm
The American Journal of Dermatopathology, 2007We report a case of a 75-year-old man with a cutaneous CD4+CD56+ hematodermic neoplasm. CD4+CD56+ hematodermic neoplasms are rare and commonly present as cutaneous lesions. This is an important diagnosis in the differential diagnosis of cutaneous hematologic malignancies because of the extremely poor prognosis.
Thomas L, Cibull +3 more
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Mycosis fungoides with a CD56+ immunophenotype
Journal of the American Academy of Dermatology, 2005We report 3 cases of mycosis fungoides (MF) with a CD56+ cytotoxic immunophenotype. Each patient presented with a different clinical phenotype: one exhibited limited poikilodermatous patches (skin stage T1); one, widespread hypopigmented lesions (skin stage T2); and one, poikiloderma with a single cutaneous tumor (skin stage T3).
E Mary, Wain +5 more
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CD4+/CD56+ hematodermic neoplasm
European Journal of Dermatology, 2011ejd.2011.1253 Auteur(s) : Marta CARLESIMO1, Elena MARI1, Giorgia CORTESI1, Diego ORSINI1 diegoorsini@libero.it, Alessandra NARCISI1, Maria Cristina COX2, Luigi RUCO3, Federica PULCINI3, Germana CAMPLONE1 1 U.O.C. Dermatology, 2 U.O.C. Hematology, 3 Department of Clinical and Molecular Medicine, S.Andrea Hospital, II School of Medicine, University of ...
CARLESIMO, Marta +8 more
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Proliferative and cytotoxic capabilities of CD16+CD56‐ and CD16±CD56+ natural killer cells
APMIS, 2000Natural killer (NK) cells can be divided into several subpopulations according to their expression of the surface antigens CD16 and CD56. The modest quantity of NK cells in the blood available for functional analysis has been a limitation in studies of NK cell subpopulations.
Søndergaard, S R +2 more
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Annales de Dermatologie et de Vénéréologie, 2004
Resume Introduction Les proliferations cutanees primitives CD4+ CD56+ constituent une entite rare de description recente, remarquables par leur tropisme cutane primaire et un phenotype CD4+ CD56+ alors que les autres marqueurs B et T sont negatifs.
M. Chamaillard +6 more
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Resume Introduction Les proliferations cutanees primitives CD4+ CD56+ constituent une entite rare de description recente, remarquables par leur tropisme cutane primaire et un phenotype CD4+ CD56+ alors que les autres marqueurs B et T sont negatifs.
M. Chamaillard +6 more
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Cutaneous CD4+ CD56+ hematologic malignancies
Journal of the American Academy of Dermatology, 2010Hematologic malignancies expressing CD4 and CD56 are most commonly associated with the recently described CD4(+) CD56(+) hematodermic neoplasm.Thirteen cases of CD4(+) CD56(+) hematologic malignancies were prospectively encountered in the routine and referral practices of the authors.Patients 1 and 2 were elderly men exhibiting an acute onset of skin ...
Cynthia M, Magro +6 more
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Agranular CD4+/CD56+ Cutaneous Neoplasm
Leukemia & Lymphoma, 2002CD4+ CD56+ cutaneous neoplasm with hematological relapse is a rare malignant disease and has been described recently in the literature as blastic or agranular NK-cell leukemia/lymphoma. The origin of this neoplasm is uncertain. We describe a 75-year-old patient with a primary cutaneous neoplasm CD4+ CD56+ who evolved to leukemic phase despite standard ...
T, Touahri +8 more
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