Results 21 to 30 of about 447,008 (222)

Cord Blood-Derived Fibroblast Activation Protein-Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo. [PDF]

Cancer Sci
We generated cord blood‐derived FAP‐targeted CAR NK cells and evaluated their activity against cancer‐associated fibroblasts. These cells showed antigen‐specific cytotoxicity in vitro and robust persistence in a pleural dissemination model, although in vivo anti‐CAF efficacy was limited, supporting further development of stromal‐targeted cellular ...
Hiroshima T, Kimura T, Maekawa M, Noguchi M, Matsui T, Ikeda S, Suga M, Nagata H, Kimura K, Fukui E, Kanou T, Ose N, Morii E, Shintani Y, Hosen N.   +14 more
europepmc   +2 more sources

The frequencies of peripheral blood CD5+CD19+ B cells, CD3−CD16+CD56+ NK, and CD3+CD56+ NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder

Allergy, Asthma & Clinical Immunology, 2022
Background Multiple sclerosis (MS) and neuromyelitis optica syndrome disease (NMOSD) are inflammatory diseases of the central nervous system. The pathogenesis and treatments for these two conditions are very different.
Leila Khani, Mir Hadi Jazayeri, Reza Nedaeinia, Mahmood Bozorgmehr, Seyed Masood Nabavi, Gordon A. Ferns   +5 more
doaj   +1 more source

Non-classic properties of human cytolytic lymphocytes. basic and clinical aspects [PDF]

, 2008
The immune system comprises a complex network of specialized cells and organs that function together to recognize and remove potentially harmful "non-self", i.e. pathogens, malignant cells and –by extension– also transplanted allogeneic cells.
Zenhäusern, Gabriela
core   +1 more source

HETEROGENEITY OF NK AND NKT LYMPHOCYTE POPULATIONS IN HEALTHY DONORS

Медицинская иммунология, 2017
Natural killer(NK) and  NKT lymphocytes are important components of innate immunity, and compose a first-line defense against cancer. These populations are characterized by high heterogeneity and are divided into several subpopulations, by differences in
D V. Tabakov, T. N. Zabotina, A. A. Borunova, I. O. Panchuk, O. V. Korotkova, Z. G. Kadagidze   +5 more
doaj   +1 more source

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection [PDF]

, 2002
Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8 cells in chronic viral infections. Here we characterize a low frequency population of CD8 cells present in chronic hepatitis B virus (HBV) infection which survive in
Ogg, GS, Antonio Bertoletti, Brown, D., Dusheiko, G., Brown, D, Geoff Dusheiko, Williams, R., George J.M. Webster, Webster, GJ, Seneviratne, SL, Webster, G.J.M., Reignat, S, David Brown, Mala K. Maini, Stephanie Reignat, King, A., Dusheiko, G, Maini, MK, Bertoletti, A, Suranjith L. Seneviratne, Roger Williams, King, A, Bertoletti, A., Reignat, S., Williams, R, Maini, M.K., Graham S. Ogg, Abigail King, Ogg, G.S., Seneviratne, S.L.   +29 more
core   +1 more source

The absence of CD56 expression can differentiate papillary thyroid carcinoma from other thyroid lesions

Indian Journal of Pathology and Microbiology, 2017
Context: The neural cell adhesion molecule CD56 is an antigen important for the differentiation of the follicular epithelium. Recent studies have reported low or absent expression of CD56 in papillary thyroid carcinoma (PTC) and its presence in normal ...
Ioana Golu, Mihaela Maria Vlad, Alis Dema, Lavinia Cristina Moleriu, Anca Tudor, Mihaela Iacob, Oana Popa, Marioara Cornianu   +7 more
doaj   +1 more source

Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. [PDF]

The Journal of experimental medicine, 1989
Neural cell adhesion molecule (N-CAM) is a membrane glycoprotein expressed on neural and muscle tissues that is involved in homotypic adhesive interactions. We have demonstrated that N-CAM also is expressed on hematopoietic cells, and is recognized by the anti-Leu-19 mAb. Leu-19 is preferentially expressed on NK cells and T lymphocytes that mediate MHC-
Lanier, LL, Testi, R, Bindl, J, Phillips, JH   +3 more
openaire   +4 more sources

Correction: Interleukin-15-Induced CD56 Myeloid Dendritic Cells Combine Potent Tumor Antigen Presentation with Direct Tumoricidal Potential.

PLoS ONE, 2014
Sébastien Anguille, Eva Lion, Jurjen Tel, I. Jolanda M de Vries, Karen Couderé, Phillip D. Fromm, Viggo F. Van Tendeloo, Evelien L. Smits, Zwi N. Berneman   +8 more
doaj   +4 more sources

Neural cell adhesion molecule (cluster of differentiation 56) in health and disease

Journal of Applied Hematology, 2015
Cluster of differentiation (CD) 56, a member of the immunoglobulin superfamily, and an isoform of neural cell adhesion molecule (NCAM), was the first cell adhesion molecule to be identified. NCAM (CD56) plays an important role both in human health and in
Syed Z. A Zaidi, Ibraheem H Motabi, Ali Al-Shanqeeti   +2 more
doaj   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2013
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Gregson, John NS, Gazzard, Brian G, Goodier, Martin R, Kuri-Cervantes, Leticia, Mela, Christopher M, Bower, Mark   +5 more
core   +1 more source