Results 161 to 170 of about 34,015 (256)

Proteomic Analysis of Serum Extracellular Vesicles Revealed Fibulin‐3 as a Novel Predictive Biomarker for Hepatocellular Carcinoma in Patients With Chronic Hepatitis B

Hepatology Research, EarlyView.
We carried out proteomic analysis of serum extracellular vesicles to identify biomarkers predictive of hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B receiving nucleos(t)ide analog therapy. Candidate proteins identified through proteomic analysis were subsequently quantified in serum by ELISA.
Emi Sometani, Kazuhiro Murai, Hayato Hikita, Jihyun Sung, Satoshi Muraoka, Hidenori Toyoda, Satoshi Tanaka, Takayuki Miyake, Shinji Kuriki, Kenji Fukumoto, Satoshi Shigeno, Yuta Myojin, Kazuki Maesaka, Kumiko Shirai, Yuki Makino, Yuki Tahata, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Jun Adachi, Tomomi Yamada, Tetsuo Takehara   +21 more
wiley   +1 more source

Size-exclusion chromatography as a clinically applicable method for extracellular vesicles collection as liquid biopsies shows potential diagnostic relevance and correlation with poorer outcome in common cancer types. [PDF]

Transl Oncol
Belényesi SK, Patmore S, Hurley S, Oner E, Saini VM, Kanjuga M, Lewis F, Menon MS, Cahill C, Tierney A, Deac O, Martinez MJS, Lowery MA, O'Leary JJ, Gately K, O'Toole S, O'Driscoll L.   +16 more
europepmc   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

Lipid-manager autophagy proteins ATG2 and ATG9 regulate extracellular vesicle secretion via amphisome biogenesis and cell lipidome modulation. [PDF]

Nat Commun
Singh A, Johnson DJ, Kuhn J, Johnson KL, Williams JG, Vancini R, Sutton D, Sharma K, Loncarek J, Borgnia MJ, Guardia CM.   +10 more
europepmc   +1 more source

Single‐Cell Atlas Reveals Neutrophil Heterogeneity in Hypervirulent Klebsiella pneumoniae Infection‐Induced Sepsis

Immunology, EarlyView.
The roles of distinct lung neutrophil compartments involved in hvKp infection remain poorly understood. Here, utilising single‐cell RNA sequencing, we identified four neutrophil subsets in the lungs of hvKp‐infected mice: N1, N2, N3a, and N3b, which were organised along a maturation trajectory.
Xiang Fang, Weizhao Li, Xinyu Zhang, Sohana Akter Mina, Qianling Jiang, Gaochen Zhu, Sheng Chen, Guan Yang   +7 more
wiley   +1 more source

Correction: Cell-free mitochondrial DNA as a potential predictor for hypoxic stress. [PDF]

Mol Biol Rep
Qu Q, Xiao C, Liu X, Huang A, Li H, Xu G, Shao N, Zhao Y, Gao B.   +8 more
europepmc   +1 more source

A Multidimensional Framework for Interpreting Macrophage Markers in the Era of Cellular Heterogeneity

Immunology, EarlyView.
Macrophage markers should be interpreted as context‐dependent biological readouts rather than deterministic cell identifiers. This Review proposes a multidimensional framework integrating lineage, identity, and functional state across complementary experimental modalities to enable a more accurate interpretation of macrophage heterogeneity.
Alessandro Palma
wiley   +1 more source

Co-enrichment of proteins in extracellular vesicles. [PDF]

Nat Commun
Shen ML, Wallucks A, Martel R, Jin Z, Alexandre L, DeCorwin-Martin P, Oliveira Fernandes de Araujo L, Ng A, Siegel PM, Juncker D.   +9 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source