Results 221 to 230 of about 120,442 (308)

Mapping the immune microenvironment of <i>KIT</i>- and <i>PDGFRA</i>-mutant GISTs reveals genotype-specific immune infiltration and TKI-induced remodeling. [PDF]

Front Immunol
Costa A, Nigro MC, Grillini M, Gozzellino L, Nannini M, Motta I, De Leo A, Pirini MG, Del Gaudio M, Ravaioli M, Ianni M, Pasquinelli G, Astolfi A, Pantaleo MA.   +13 more
europepmc   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Early Cardiotoxic Remodelling Precedes Hepatic Fibrosis and Increases Susceptibility to Lethal Arrhythmias in Wild-Type MASH Mice. [PDF]

Clin Exp Pharmacol Physiol
Liu J, Yamashita K, Yamano S.
europepmc   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

Macrophages increase in corneal epithelium and stroma after photorefractive keratectomy-like corneal abrasion and amplify ocular pain responses in rats. [PDF]

Exp Eye Res
Hegarty DM, Jiang CL, Gunter C, Semidey D, Morgans CW, Largent-Milnes TM, Aicher SA.   +6 more
europepmc   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

Association of intratumoral CD68⁺CD163⁺ M2-like macrophages with survival in metastatic colorectal cancer treated with chemotherapy plus bevacizumab. [PDF]

Front Immunol
Xin X, Qiu H, Zang Y, Zhou L, Qin T, Kong Q.   +5 more
europepmc   +1 more source

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

Advanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang, Soon Jin Choi, Khandoker Asiqur Rahaman, Tae Kyoung Lee, Gwangbin Lee, Jaeyeon Jun, Hyeon‐Jeong Lee, Hophil Min, Hojeong Jeon, Jung Keun Hyun, Hyung‐Seop Han, Jimin Park   +11 more
wiley   +1 more source

Macrophages, TGF-β1 expression and iron deposition in development of NASH

Open Medicine, 2012
Ananiev Julian, Penkova Mariana, Tchernev Georgi, Gulubova Maya   +3 more
doaj   +1 more source

Immunophenotypic Characterization of Tumor-Associated Macrophages in Oral Carcinogenesis: An Observational Study. [PDF]

Int J Mol Sci
Alves M, Ferreira S, Garcês F, Espíndula C, Salazar F, Pacheco JJ, Diniz-Freitas M, Lopes C, Warnakulasuriya S, Delgado L, Monteiro L.   +10 more
europepmc   +1 more source