Results 151 to 160 of about 36,435 (217)

PD-L1 Expression and Immune Microenvironment Remodeling During Laryngeal Carcinogenesis: Implications for Malignant Progression of Laryngeal Dysplasia. [PDF]

Int J Mol Sci
Tudor F, Marijić B, Babarović E, Hadžisejdić I.   +3 more
europepmc   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Differences in mRNA expression of neuroinflammation-related genes in the temporal lobe of patients with drug-resistant focal epilepsy. [PDF]

Epileptic Disord
Tan THL, McLean C, Christie M, Sanfilippo P, Drill M, Perucca P, Kwan P, O'Brien TJ, Monif M.   +8 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Multinucleated Giant Cells in Human Pancreatic Cancer Are a Distinct Macrophage Population Undergoing a DNA Damage Response and Associated with an Aggressive Tumor Microenvironment. [PDF]

Cancer Immunol Res
Viatore M, Polidori R, Putignano AR, Bonometti A, Rahal D, Barbagallo M, Veghini L, Donisi G, Basso G, Giuliano D, Marchini S, Erreni M, Fumagalli MR, Pasqualini F, Grizzi F, Spaggiari P, Uccella S, Bozzarelli S, Zerbi A, Capretti GL, Corbo V, Locati M, Mantovani A, Marchesi F.   +23 more
europepmc   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Mesenchymal Stromal Cells Improve Postoperative Cardiac Dysmaturation in a Juvenile Porcine Model. [PDF]

J Am Heart Assoc
Furuta A, Nishiori H, Aharonyan A, Devoto A, Ejim EJ, Paruchuri R, Henmi S, Kobayashi K, Kobayashi K, Lin S, Wang PC, Tu TW, Ishibashi N.   +12 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

CLEC3B (tetranectin) expression is associated with vascular localization and tumor aggressiveness in breast cancer. [PDF]

Int J Med Sci
Wei CT, Yu TH, Hsu CC, Hsuan CF, Hung WC, Wang CP, Tang WH, Chung FM, Lee YJ, Chang CC, Chen CC.   +10 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source