Results 201 to 210 of about 35,344 (261)

NLRP3-Caspase-1 Axis in Human Adipose Tissue Crown-Like Structures: A Potential Mediator of Inflammation and the Effects of Bariatric Surgery. [PDF]

Immun Inflamm Dis
Palomäki VA, Väyrynen JP, Koivukangas V, Meriläinen S, Karttunen TJ, Lehenkari P.   +5 more
europepmc   +1 more source

A Versatile Multiplexed Immunofluorescence Strategy for Efficient, Host‐Independent, and Scalable Spatial Protein Profiling

Small Methods, EarlyView.
Crowding‐enhanced multiplex immunofluorescence (umIF) provides a versatile strategy for scalable spatial profiling in FFPE tissues. By improving labeling efficiency across direct, one‐step, and two‐step IF formats, umIF enables host‐species‐independent use of primary antibodies and antibody–nanobody complexes, detection of weak targets, and multicycle ...
Phuong Nguyen, Hongqiang Ma, Dimitrios S. Gotsis, Maomao Chen, Chaojie Zhang, Tushar Talukder Showrav, Marc Schwartz, Brenda Diergaarde, Robert E. Schoen, Rhonda M. Brand, Hua Zhang, Yang Liu   +11 more
wiley   +1 more source

Breast cancer microenvironment composition associated with high PD-L1 expression. [PDF]

BMC Cancer
Chekhun V, Lukianova Y, Mushii O, Zadvornyi T, Pavlova A, Burda T, Bazas V, Shepelenko I, Lukianova N.   +8 more
europepmc   +1 more source

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

Microglial response to sleep deprivation depends on the hippocampal region and paradigm used in adult male mice. [PDF]

Brain Behav Immun Health
Kox J, Picard K, Šimončičová E, Vidal V, Khakpour M, Wilhelm S, Burns S, González Ibáñez F, Ben-Azu B, Havekes R, Tremblay MÈ.   +10 more
europepmc   +1 more source

Targeting Inflammatory Alarmin S100A9 Modulates Activation of Pro‐Inflammatory Macrophage to Protect Nasal Epithelial Cells From LPS‐Induced Epithelial–Mesenchymal Transition

Microbiology and Immunology, EarlyView.
ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) exhibits pronounced endotypic heterogeneity, with macrophages serving as key drivers of sustained mucosal inflammation. In this study, we identify S100A9 as a macrophage‐derived alarmin that is markedly elevated in CRSwNP tissues.
Yunxiang Ji, Jia Luan, Fang Yuan, Zhao Wang, Ran Wei, Guangbin Sun   +5 more
wiley   +1 more source

Increased Infiltration of CD4⁺, CD8⁺, and CD68⁺ Cells at the Invasive Front Is Associated With Favorable Prognosis in Obstructive Colorectal Cancer: A Retrospective Observational Study. [PDF]

Cancer Rep (Hoboken)
Takahashi G, Shinji S, Ishiwata T, Yamada T, Uehara K, Matsuda A, Arai T, Ohashi R, Yokoyama Y, Iwai T, Yoshida H.   +10 more
europepmc   +1 more source

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Allergy, EarlyView.
Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T‐cell release of barrier‐repressing cytokines (IL‐4, IL‐13, IL‐22, OSM). Cytokine signalling drives JAK‐dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic‐mediated eradication of S. aureus induces
Maria Gluud, Emil M. Pallesen, Ziao Zeng, Martin R. J. Namini, Chella Krishna Vadivel, Lise Mette Rahbek Gjerdrum, Lang Yan, Sana Ahmad, Lise M. Lindahl, Michael Bzorek, Maria R. Kamstrup, Saptaswa Dey, Sisse Rye Ostrowski, Erik Sørensen, Pia Rantakari, Charlotte Menne Bonefeld, Carsten Geisler, Anders Woetmann, Riitta Lahesmaa, Lars Iversen, Peter Wolf, Thomas Litman, Terkild B. Buus, Niels Ødum   +23 more
wiley   +1 more source

Pathway-Specific Effects of Oral Corticosteroids on Eosinophilic Inflammation and Tissue Remodeling in Chronic Rhinosinusitis with Nasal Polyps. [PDF]

Int J Mol Sci
Radajewski K, Burduk P, Wierzchowska M, Antosik P, Jóźwicki J, Burduk J, Grzanka D.   +6 more
europepmc   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source