Results 181 to 190 of about 36,435 (217)

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Vessel-associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease. [PDF]

Brain Pathol
Milner O, Fisher RA, Asby DJ, Cross S, Boche D, Miners JS.   +5 more
europepmc   +1 more source

Chronic Pruritic Papular Eruption in an Elderly Man

JEADV Clinical Practice, EarlyView.
Filipe Monteiro, Inês Tribolet‐Abreu, Gustavo Almeida‐Silva, Inês Amaral, Ivânia Soares, Sónia Fernandes, Joana Antunes   +6 more
wiley   +1 more source

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses

Phytotherapy Research, EarlyView.
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang, Jing Wang, Tianyi Wang, Qihao Fu, Jiawen Xu, Chaochen Li, Zheng Zhou, Chenxi Zhang, Guanhua Xu, Mingjie Xia, Zhiming Cui   +10 more
wiley   +1 more source

Macrophage-associated SLAMF9 is a potential therapeutic target for glioma. [PDF]

Transl Cancer Res
Yin K, Han X, Liu Z, Bai X, Gao J, Zhang Q.   +5 more
europepmc   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Monocytes strongly induce (myo)fibroblast contraction in a 3D skin model to understand inflammation-fibrosis crosstalk. [PDF]

Sci Rep
Zanin-Silva DC, van Kooten NJT, Papadimitriou TI, Dorst DN, Walgreen B, Vitters EL, van den Bosch MHJ, Koenders MI, van Caam APM.   +8 more
europepmc   +1 more source

Reconciling Granular Hydrogel Microstructure and Mechanics via a Temporary Thermo‐Responsive and Cell‐Invadable Matrix

Small, EarlyView.
Thermo‐responsive granular hydrogels (TRGHs), composed of microparticles and an interstitial matrix, exhibit thermo‐responsive mechanical properties and allow cell infiltration. This system effectively addresses the conventional compromise between mechanical strength and porosity observed in granular hydrogels.
Jun Kim, Soyeon Kwon, Taimoor H. Qazi
wiley   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source

<i>Lactobacillus paracasei</i> effectively protects neuronal function in severe traumatic brain injury in rats by suppressing systemic inflammation. [PDF]

Am J Transl Res
Tu Y, Wang Z, Han D, Liu Y, Hong D, Niu F.   +5 more
europepmc   +1 more source