Results 181 to 190 of about 35,344 (261)

Suppressive effect of lemon (<i>Citrus limon</i> L. Burm. f.) extract toward pro-tumor immune response in DMBA-induced carcinogenesis mouse. [PDF]

Avicenna J Phytomed
Putra WE, Nuruzzulfa C, Mahabella DE, Nuraıda RFI, Hıdayatullah A, Rifa'i M.   +5 more
europepmc   +1 more source

Early gut microbial and metabolic dysregulation with subclinical cardiac alterations in a nonhuman primate model of Rett syndrome

iMeta, EarlyView.
Longitudinal multi‐omics profiling of a nonhuman primate Rett syndrome (RTT) model reveals early systemic alterations. RTT monkeys exhibited postnatal growth retardation, intestinal structural abnormalities, and low‐grade systemic inflammation. Gut microbiome analysis showed delayed microbial maturation and age‐discordant dysbiosis, including altered ...
Ting Zhang, Xiaopeng Wang, Peng Li, Junyu Zhang, Wenjie Sun, Zhen Zhang, Yan Zhuo, Wenting Guo, Yongchang Chen   +8 more
wiley   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

The B7-H3/CD3 immune phenotype identifies prognostic subgroups in neuroblastoma. [PDF]

Front Immunol
Rasic P, Samardzija G, Djuricic SM, Mitrovic N, Bogosavljevic A, Milicevic A, Soldatovic I, Stefanovic O, Krstovski N, Kuzmanovic M, Aleksic D, Redzic D, Rodic P, Lazic J, Milosevic G, Svorcan J, Radeta R, Milickovic M, Dundjerovic D.   +18 more
europepmc   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Clinicopathological and molecular characterization of tumor-associated macrophages in sporadic and Xeroderma Pigmentosum-related cutaneous melanoma. [PDF]

BMC Cancer
Chikhaoui A, Tounsi H, Nabouli I, Jones M, Jenni R, Ahmed MB, Naouali C, Zghal M, Turki H, Yacoub-Youssef H.   +9 more
europepmc   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Tumor-Associated Macrophage Infiltration and PD-L1 Expression in Gastric Cancer According to a Modified TCGA-Based Classification. [PDF]

J Gastric Cancer
Song B, Koo DH, Kim EJ, Do IG, Chu J, Kim K, Lee H, Kwon MJ, Park JH, Son BH, Yoo CH, Chae SW.   +11 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Placental Histiocyte Phenotypes in Chronic Histiocytic Intervillositis: A Comprehensive Immunophenotypic and Morphologic Atlas. [PDF]

Int J Mol Sci
Gradhand E, Strahler L, Bein J, Mijatovic M, Hullmeine HI, Weigert A, Spahn S, Herrmann E, Bahlmann F, Hullmeine E.   +9 more
europepmc   +1 more source