Results 1 to 10 of about 419,552 (297)

CD103+CD8+ tissue‐resident memory T lymphocytes of melanoma boost anti‐tumour immunity and predict immunotherapy outcomes [PDF]

Clinical and Translational Medicine
Background Immunotherapy has revolutionised melanoma treatment, providing significant clinical benefits by reactivating the anti‐tumour immune system. CD8+ tissue‐resident memory T lymphocytes (CD8+ TRM) have emerged as crucial mediators of anti‐tumour ...
Tianyi Zhang, Junquan Song, Yinlam Li, Kangjie Shen, Jiangying Xuan, Yuan Gao, Lili Lu, Zhi Pang, Lu Wang, Yang Yang, Zixu Gao, Qianrong Hu, Yu Zhu, Chenlu Wei, Shaoluan Zheng, Rongkui Luo, Yingyong Hou, Yuhong Zhou, Chuanyuan Wei, Jianying Gu   +19 more
doaj   +2 more sources

Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas [PDF]

Journal of Pathology and Translational Medicine, 2021
Background Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction.
Dina Mohamed El Samman, Manal Mohamed El Mahdy, Hala Sobhy Cousha, Zeinab Abd El Rahman Kamar, Khaled Abdel Karim Mohamed, Hoda Hassan Abou Gabal   +5 more
doaj   +1 more source

Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases [PDF]

Research in Oncology, 2022
Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative ...
Elia Hakim, Amina Mostafa, Mohamed Mohamed, Mahmoud Sherif, Maha El Naggar   +4 more
doaj   +1 more source

CD8+ T Cells in Atherosclerosis [PDF]

Cells, 2020
Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly dysfunctional and exhausted cell phenotypes.
Sarah Schäfer, Alma Zernecke
openaire   +4 more sources

Cytokines profile in patients with hydatidosis in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection ...
Ahmed Mohammed A Al-Mosawi, Fadhil Farhood M Al-Joborae, Huda Fadhil Al-Joborae, Mohammed Abd Kadhum Al-Saadi, Alaa H Al-Charrakh   +4 more
doaj   +1 more source

CD8 Lineage Commitment in the Absence of CD8 [PDF]

Immunity, 1997
The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-
Ananda W. Goldrath, Kristin A. Hogquist, Michael J. Bevan   +2 more
openaire   +3 more sources

CD8+ T Cell Exhaustion in Cancer [PDF]

Frontiers in Immunology, 2021
A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now revealed that CD8+ Tex is composed of multiple interconnected subpopulations.
Graham D. Thomas, Joseph S. Dolina, Natalija Van Braeckel-Budimir, Shahram Salek-Ardakani   +3 more
openaire   +4 more sources

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

CTL priming by CD8+ and CD8– dendritic cellsin vivo [PDF]

European Journal of Immunology, 1999
Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been ...
Ruedl, C, Bachmann, M
openaire   +3 more sources

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function [PDF]

The Journal of Immunology, 2000
Abstract To investigate the molecular basis that makes heterodimeric CD8αβ a more efficient coreceptor than homodimeric CD8αα, we used various CD8 transfectants of T1.4 T cell hybridomas, which are specific for H-2Kd, and a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS 252–260 (SYIPSAEKI).
Bernard Malissen, Claude Grégoire, Ed Palmer, Sabine H. Stotz, Alexandre Arcaro, Nicole Boucheron, Immanuel F. Luescher   +6 more
openaire   +3 more sources