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CD8+ T Cell Exhaustion in Cancer [PDF]

Frontiers in Immunology, 2021
A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now ...
Joseph S. Dolina, Natalija Van Braeckel‐Budimir, G. Thomas, Shahram Salek-Ardakani   +3 more
semanticscholar   +5 more sources

Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas [PDF]

Journal of Pathology and Translational Medicine, 2021
Background Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction.
Dina Mohamed El Samman, Manal Mohamed El Mahdy, Hala Sobhy Cousha, Zeinab Abd El Rahman Kamar, Khaled Abdel Karim Mohamed, Hoda Hassan Abou Gabal   +5 more
doaj   +1 more source

Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases [PDF]

Research in Oncology, 2022
Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative ...
Elia Hakim, Amina Mostafa, Mohamed Mohamed, Mahmoud Sherif, Maha El Naggar   +4 more
doaj   +1 more source

Cytokines profile in patients with hydatidosis in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection ...
Ahmed Mohammed A Al-Mosawi, Fadhil Farhood M Al-Joborae, Huda Fadhil Al-Joborae, Mohammed Abd Kadhum Al-Saadi, Alaa H Al-Charrakh   +4 more
doaj   +1 more source

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine

Nature, 2021
SARS-CoV-2 spike mRNA vaccines1–3 mediate protection from severe disease as early as ten days after prime vaccination3, when neutralizing antibodies are hardly detectable4–6.
V. Oberhardt, Hendrik Luxenburger, J. Kemming, I. Schulien, Kevin Ciminski, S. Giese, B. Csernalabics, Julia Lang-Meli, I. Janowska, J. Staniek, K. Wild, K. Basho, M. Marinescu, Jonas Fuchs, Fernando Topfstedt, A. Janda, Oezlem Sogukpinar, H. Hilger, K. Stete, F. Emmerich, B. Bengsch, C. Waller, S. Rieg, Sagar, T. Boettler, K. Zoldan, G. Kochs, M. Schwemmle, M. Rizzi, R. Thimme, C. Neumann-Haefelin, M. Hofmann   +31 more
semanticscholar   +1 more source

Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma

Cancer Biology & Medicine, 2023
Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy. CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB) have been significantly correlated with the outcome of patients with PDAC, but the correlations have been ...
Tianxing Zhou, Quan Man, Xueyang Li, Yongjie Xie, Xupeng Hou, Hailong Wang, Jingrui Yan, Xueqing Wei, Weiwei Bai, Ziyun Liu, Jing Liu, Jihui Hao   +11 more
doaj   +1 more source

Respiratory Syncytial Virus Infection Induces Expression of Inducible Nitric Oxide Synthase, CD3, and CD8 in Naturally Occurring Pneumonia in Lambs

Acta Veterinaria, 2021
Respiratory syncytial virus (RSV) is an RNA virus that belongs to the Pneumovirus genus of the Paramyxoviridae family. The aim of this study was to evaluate the expressions of inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 ...
Yaman Turan, Aydemir Ceyhun
doaj   +1 more source

Digital image analysis for estimating stromal CD8+ tumor-infiltrating lymphocytes in lung adenocarcinoma

Journal of Pathology Informatics, 2021
Background: Stromal CD8+ tumor-infiltrating lymphocytes (TILs) are an important prognostic and predictive indicator in non-small cell lung cancer (NSCLC).
Iny Jhun, Daniel Shepherd, Yin P Hung, Emilio Madrigal, Long P Le, Mari Mino-Kenudson   +5 more
doaj   +1 more source

The Immunomodulatory Effects of Ginger (Zingiber officinale) Extract on CD4 and CD8 Expression in Spleen of Diabetic Rats

Namık Kemal Tıp Dergisi, 2023
Aim:This study aims to examine the changes of the ginger extract treatment on CD4 and CD8 expressions in the spleen tissue of rats, in which the experimental diabetes was induced with streptozotocin.Materials and Methods:Forty Wistar albino rats were ...
Buket BAKIR
doaj   +1 more source