Results 1 to 10 of about 561,784 (370)

CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer [PDF]

Cell Communication and Signaling
Background Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Despite advancements in therapeutic methodologies, it still causes a high rate of patient mortality. CD8+ tissue-resident memory T (TRM) cells are strategically positioned
Zi-Xin Wu, Tian-Tian Da, Chuan Huang, Xiao-Qing Wang, Liang Li, Zhi-Bin Zhao, Ting-Ting Yin, Hai-Qing Ma, Zhe-Xiong Lian, Jie Long, Fei Wang, Jie Cao   +11 more
doaj   +2 more sources

Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas [PDF]

Journal of Pathology and Translational Medicine, 2021
Background Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction.
Dina Mohamed El Samman, Manal Mohamed El Mahdy, Hala Sobhy Cousha, Zeinab Abd El Rahman Kamar, Khaled Abdel Karim Mohamed, Hoda Hassan Abou Gabal   +5 more
doaj   +1 more source

Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases [PDF]

Research in Oncology, 2022
Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative ...
Elia Hakim, Amina Mostafa, Mohamed Mohamed, Mahmoud Sherif, Maha El Naggar   +4 more
doaj   +1 more source

Cytokines profile in patients with hydatidosis in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection ...
Ahmed Mohammed A Al-Mosawi, Fadhil Farhood M Al-Joborae, Huda Fadhil Al-Joborae, Mohammed Abd Kadhum Al-Saadi, Alaa H Al-Charrakh   +4 more
doaj   +1 more source

CD8 Lineage Commitment in the Absence of CD8 [PDF]

Immunity, 1997
The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-
Ananda W. Goldrath, Kristin A. Hogquist, Michael J. Bevan   +2 more
openaire   +3 more sources

Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct

OncoImmunology, 2022
Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li, Summer Zhuang, Antja Heit, Si-Lin Koo, Aaron C. Tan, I-Ting Chow, William W. Kwok, Iain Beehuat Tan, Daniel S.W. Tan, Yannick Simoni, Evan W. Newell   +10 more
doaj   +1 more source

CTL priming by CD8+ and CD8– dendritic cellsin vivo [PDF]

European Journal of Immunology, 1999
Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been ...
Ruedl, C, Bachmann, M
openaire   +3 more sources

Contrasted TCRβ Diversity of CD8+ and CD8− T Cells in Rainbow Trout [PDF]

PLoS ONE, 2013
Teleost fish express highly diverse naive TCRβ (TRB) repertoires and mount strong public and private clonal responses upon infection with pathogens. Fish T cells express typical markers such as CD8, CD4-1 and CD4-2, CD3, CD28 and CTLA4. Fish CD8(+) T cells have been shown to be responsible for antigen-specific cell-mediated cytotoxicity in in vitro ...
Castro, Dona Maria Rosario, Takizawa, Fumio, Chaara, Wahiba, Lunazzi, Aurélie, Dang, Thi Huong, Koellner, Bernd, Quillet, Edwige, Six, Adrien, Fischer, Uwe, Boudinot, Pierre   +9 more
openaire   +10 more sources

Respiratory Syncytial Virus Infection Induces Expression of Inducible Nitric Oxide Synthase, CD3, and CD8 in Naturally Occurring Pneumonia in Lambs

Acta Veterinaria, 2021
Respiratory syncytial virus (RSV) is an RNA virus that belongs to the Pneumovirus genus of the Paramyxoviridae family. The aim of this study was to evaluate the expressions of inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 ...
Yaman Turan, Aydemir Ceyhun
doaj   +1 more source

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function [PDF]

The Journal of Immunology, 2000
Abstract To investigate the molecular basis that makes heterodimeric CD8αβ a more efficient coreceptor than homodimeric CD8αα, we used various CD8 transfectants of T1.4 T cell hybridomas, which are specific for H-2Kd, and a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS 252–260 (SYIPSAEKI).
Bernard Malissen, Claude Grégoire, Ed Palmer, Sabine H. Stotz, Alexandre Arcaro, Nicole Boucheron, Immanuel F. Luescher   +6 more
openaire   +3 more sources