Results 1 to 10 of about 579,243 (371)
CD8+ T Cell Exhaustion in Cancer [PDF]
Frontiers in Immunology, 2021 A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is underway. Originally thought to be a uniform population that progressively loses effector function in response to persistent antigen, single-cell analysis has now ...
Joseph S. Dolina +3 more
semanticscholar +5 more sources
Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas [PDF]
Journal of Pathology and Translational Medicine, 2021 Background Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction.
Dina Mohamed El Samman +5 more
doaj +1 more source
Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases [PDF]
Research in Oncology, 2022 Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative ...
Elia Hakim +4 more
doaj +1 more source
CD8+ T Cells in Atherosclerosis [PDF]
Cells, 2020 Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly dysfunctional and exhausted cell phenotypes.
Sarah Schäfer, Alma Zernecke
openaire +4 more sources
Cytokines profile in patients with hydatidosis in Babylon Province, Iraq
Medical Journal of Babylon, 2023 Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection ...
Ahmed Mohammed A Al-Mosawi +4 more
doaj +1 more source
CD8 Lineage Commitment in the Absence of CD8 [PDF]
Immunity, 1997 The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-
Ananda W. Goldrath +2 more
openaire +3 more sources
Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
OncoImmunology, 2022 Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li +10 more
doaj +1 more source
CTL priming by CD8+ and CD8– dendritic cellsin vivo [PDF]
European Journal of Immunology, 1999 Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been ...
Ruedl, C, Bachmann, M
openaire +3 more sources
Journal of Pathology Informatics, 2021 Background: Stromal CD8+ tumor-infiltrating lymphocytes (TILs) are an important prognostic and predictive indicator in non-small cell lung cancer (NSCLC).
Iny Jhun +5 more
doaj +1 more source
Contrasted TCRβ Diversity of CD8+ and CD8− T Cells in Rainbow Trout [PDF]
PLoS ONE, 2013 Teleost fish express highly diverse naive TCRβ (TRB) repertoires and mount strong public and private clonal responses upon infection with pathogens. Fish T cells express typical markers such as CD8, CD4-1 and CD4-2, CD3, CD28 and CTLA4. Fish CD8(+) T cells have been shown to be responsible for antigen-specific cell-mediated cytotoxicity in in vitro ...
Castro, Dona Maria Rosario +9 more
openaire +10 more sources