Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]
, 2006 The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C +5 more
core +3 more sources
Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma [PDF]
OncoImmunology, 2018 Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen +10 more
doaj +2 more sources
Immunohistochemical expression of programmed death-ligand 1 and CD8 in glioblastomas [PDF]
Journal of Pathology and Translational Medicine, 2021 Background Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction.
Dina Mohamed El Samman +5 more
doaj +1 more source
Tumor Infiltrating Lymphocytes Predicting Long-Term Outcomes in HER2-Negative Breast Cancer Patients with Visceral Metastases [PDF]
Research in Oncology, 2022 Background: Tumor-infiltrating lymphocytes (TILs) were found to be associated with a better clinical outcome in specific subtypes of breast cancer. Aim: To study the association between TILs and the prognosis of Egyptian patients with HER2-negative ...
Elia Hakim +4 more
doaj +1 more source
Cytokines profile in patients with hydatidosis in Babylon Province, Iraq
Medical Journal of Babylon, 2023 Background: Hydatidosis is caused by infection with the larval stage of the Cestode Echinococcus granulosus. Objective: In vitro quantitative evaluation of interleukin 6 (IL-6), INF-gamma (INF-γ), and CD4 and CD8 molecules during hydatidosis infection ...
Ahmed Mohammed A Al-Mosawi +4 more
doaj +1 more source
Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinct
OncoImmunology, 2022 Tumor-specific T cells likely underpin effective immune checkpoint-blockade therapies. Yet, most studies focus on Treg cells and CD8+ tumor-infiltrating lymphocytes (TILs).
Shamin Li +10 more
doaj +1 more source
Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells. [PDF]
, 2014 Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection.
Chou, Jennifer P +4 more
core +9 more sources
Cancer Biology & Medicine, 2023 Objective: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy. CD8+ T cells, cancer stem cells (CSCs), and tumor budding (TB) have been significantly correlated with the outcome of patients with PDAC, but the correlations have been ...
Tianxing Zhou +11 more
doaj +1 more source
Journal of Pathology Informatics, 2021 Background: Stromal CD8+ tumor-infiltrating lymphocytes (TILs) are an important prognostic and predictive indicator in non-small cell lung cancer (NSCLC).
Iny Jhun +5 more
doaj +1 more source
Acta Veterinaria, 2021 Respiratory syncytial virus (RSV) is an RNA virus that belongs to the Pneumovirus genus of the Paramyxoviridae family. The aim of this study was to evaluate the expressions of inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 ...
Yaman Turan, Aydemir Ceyhun
doaj +1 more source