Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]
Journal of Virology, 1988 The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments. At a stage of pathogenesis when virus had already colonized target tissues, a therapeutic antiviral function could be ascribed to the CD8+ subset.
Matthias J. Reddehase +4 more
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Autologous GPC3/NY-ESO-1/AFP specific CD8-positive T-lymphocytes [PDF]
, 2020 National Cancer Institute
openalex +2 more sources
CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer [PDF]
Iranian Journal of Immunology, 2023 Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be targeted to block adenosine-mediated immunosuppression.Objective: To analyze the relationship between the CD39 expression and ...
Kuo Zhao, Dongmei Han, Lu Tang, Hao Jin
doaj +1 more source
مجله دانشکده پزشکی اصفهان, 2017 Background: CD8-positive T lymphocytes are important part of cell-mediated immunity and play a central role in induction of immune response against tumor progression.
Simin Hemati +3 more
doaj +1 more source
Aerobic training modulates T cell activation in elderly women with knee osteoarthritis [PDF]
Brazilian Journal of Medical and Biological Research, 2016 Osteoarthritis of the knee (kOA) is a disease that mainly affects the elderly and can lead to major physical and functional limitations. However, the specific effects of walking, particularly on the immune system, are unknown. Therefore, this study aimed
W.F. Gomes +7 more
doaj +3 more sources
CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma
Archives of Medical Science, 2023 Introduction The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity.
Lu Tang, Hao Jin
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CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity [PDF]
Journal of Virology, 1987 We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by virus-specific CD8+ CD4-T lymphocytes.
Reddehase, Matthias J. +4 more
openaire +3 more sources
Natalizumab affects T-cell phenotype in multiple sclerosis: implications for JCV reactivation [PDF]
, 2016 The anti-CD49d monoclonal antibody natalizumab is currently an effective therapy against the relapsing-remitting form of multiple sclerosis (RRMS). Natalizumab therapeutic efficacy is limited by the reactivation of the John Cunningham polyomavirus (JCV ...
A Bellizzi +51 more
core +10 more sources
Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19
Journal of Intensive Care, 2021 We evaluated the peripheral blood immune responses of lymphocytes in severe Coronavirus disease 2019 (COVID-19) patients in different stages of recovery using single-cell mass cytometry.
Yumi Mitsuyama +5 more
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