Immunohistochemical Characterization of the Immune Response in Chronic Endometritis Caused by <i>Chlamydia trachomatis</i>. [PDF]
Miranda-Maldonado I +6 more
europepmc +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Protocol for multi-organ isolation of murine leukocytes for flow cytometry. [PDF]
Layug PJ +4 more
europepmc +1 more source
CD4 positive/CD8 negative/CD56 positive T cell large granular lymphocyte proliferations; clonal disorders of uncertain significance [PDF]
Deepti Mutreja +3 more
openalex +1 more source
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen +12 more
wiley +1 more source
Protection Against Type 1 Diabetes Development in Mice With 4E-BP2 Deletion. [PDF]
Pita-Grisanti V +7 more
europepmc +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Interplay Between Immune Microenvironment CD8<sup>+</sup> Tumor-Infiltrating Lymphocytes and PDL-1 Expression as Prognostic Markers in Invasive Cervical Squamous Cell Carcinoma. [PDF]
Petrică LA +10 more
europepmc +1 more source

