Results 221 to 230 of about 289,022 (294)

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Altered expression of the CD26/ADA axis in immune-mediated inflammation of infectious mononucleosis. [PDF]

Sci Rep
Shi T, Shi W, Tian J, Huang L.
europepmc   +1 more source

Single cell RNA transcriptome response to fentanyl use in persons with HIV infection. [PDF]

Sci Rep
Roskin KM, Meeds HL, Krishnan JM, Juhascik M, Cafardi JM, Brown JL, Freiermuth C, Lyons MS, Sherman KE, Blackard JT.   +9 more
europepmc   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

The Multifaceted Role of Androgen Receptor Signaling in Immunity: Implications for Oncology. [PDF]

Mol Cancer Res
Lee P, Nelson PS.
europepmc   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Dietary conjugated linoleic acid enhances resistance to <i>Salmonella</i> infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells. [PDF]

Gut Microbes
Deng L, Wang X, Mebratie DY, Tang Y, Hu J, Qi J, Tian M, Bao Y, Zhu L, Wang S.   +9 more
europepmc   +1 more source

PHENOTYPIC T-CELL CHANGES IN THORACIC TRANSPLANT RECIPIENTS IMMUNOSUPPRESSED WITH FK506 [PDF]

, 1991
ARMITAGE, J, DUQUESNOY, R, GRIFFITH, B, KAUFMAN, C, KEENAN, R, KORMOS, R, STARZL, T, YOUSEM, S, ZEEVI, A, ZERBE, T   +9 more
core  

PEPITEM Regulates the Synovial Microenvironment During Immune‐Mediated Inflammatory Arthritis to Limit Disease

Arthritis &Rheumatology, EarlyView.
Objective Here we investigate the status of the adiponectin–PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. Methods Peripheral blood was isolated from patients with clinical suspect arthralgia and suspected inflammatory ...
Mussarat Wahid, Samuel Kemble, Oladimeji Abudu, Anella Saviano, Christopher Mahony, Jonathan W. Lewis, Thomas A. Nicholson, Anna Schettino, Noemi Marigliano, Kathryn Frost, Jenefa Begum, Alyssa M. Urbanowski, Marion Limo, Rakesh Jha, Sandra Martinez Jarquin, Laleh Pezhman, Abbie E. A. Degan, Amy E. Anderson, Charlotte G. Smith, Armaiti Batki, Holly Adams, Francesco Caso, Raffaele Scarpa, Iain McInnes, Stefan Siebert, Arthur G. Pratt, Andrew Filer, Karim Raza, Adam P. Croft, Myriam Chimen, Felicity de Cogan, G. Ed Rainger, Asif J. Iqbal, Francesco Maione, Helen M. McGettrick   +34 more
wiley   +1 more source

M2 macrophages predict response to neoadjuvant chemotherapy in triple negative breast cancer patients. [PDF]

Sci Rep
Chen WX, Yang M, Shao QF, Zhu B, Xue J, Zheng L, Qin XH, Qi CJ.   +7 more
europepmc   +1 more source