Results 11 to 20 of about 883,722 (384)
Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells. [PDF]
, 1989 We report here a mAb, 14-2, reactive with TCRs that include V beta 14. The frequency of V beta 14+ T cells varies with CD4 and CD8 subset and is controlled by the H-2 genes.
Nan‐Shih Liao +2 more
openalex +4 more sources
CD8+ T Cells in Atherosclerosis [PDF]
Cells, 2020 Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly dysfunctional and exhausted cell phenotypes.
Sarah Schäfer, Alma Zernecke
openaire +4 more sources
G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment. [PDF]
, 2018 The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8αα intraepithelial lymphocyte compartment.
Cyster, Jason G, Sumida, Hayakazu
core +11 more sources
CD8 Lineage Commitment in the Absence of CD8 [PDF]
Immunity, 1997 The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-
Ananda W. Goldrath +2 more
openaire +3 more sources
CTL priming by CD8+ and CD8– dendritic cellsin vivo [PDF]
European Journal of Immunology, 1999 Two distinct developmental pathways are driving the formation of myeloid- and lymphoid-related dendritic cells (DC) which differ in anatomical localization and phenotype. In terms of function, it has been hypothesized that only the myeloid-related CD8(-) DC are able to initiate immune responses, whereas the lymphoid-related CD8(+) DC have been ...
Ruedl, C, Bachmann, M
openaire +3 more sources
Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function [PDF]
The Journal of Immunology, 2000 Abstract To investigate the molecular basis that makes heterodimeric CD8αβ a more efficient coreceptor than homodimeric CD8αα, we used various CD8 transfectants of T1.4 T cell hybridomas, which are specific for H-2Kd, and a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS 252–260 (SYIPSAEKI).
Bernard Malissen +6 more
openaire +3 more sources
CD8+ Lymphomatoid Papulosis [PDF]
Annals of Dermatology, 2011 Lymphomatoid papulosis (LyP) is defined as a histologically malignant, but clinically benign condition. It can appear as erythematous pink to purple papules or nodules. Immunophenotyping studies of the lymphomatoid papulosis lesions have shown a predominance of a CD4 expression and negativity for CD8.
You Chan Kim, Ji Hyun Sim
openaire +3 more sources
Collisional variant of CD8+ mycosis fungoides and indolent CD8+ lymphoid proliferation [PDF]
JAAD Case Reports, 2020 Abstract: CD8+ lymphoid infiltrates of the skin are classified into different subtypes with variable prognoses and treatment options. Here, we present a patient with CD8+ mycosis fungoides who developed CD8+ indolent lymphoid proliferation in a background of conventional plaque stage CD8+ mycosis fungoides.
Larisa J. Geskin +3 more
openaire +4 more sources
Indian Journal of Pathology and Microbiology, 2023 Context: The expression of programmed cell death ligand1 (PDL1) is a research hotspot of immunotherapy. The treatment targeted for its expression has shown effectiveness in many tumors. Objective: The aim of the study was to determine PD-L1 expression in
Yanfeng Bai +6 more
doaj +1 more source
KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Science, 2022 In this work, we find that CD8+ T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49+CD8+ regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety
Jing Li +35 more
semanticscholar +1 more source