Results 211 to 220 of about 436,454 (294)

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

A Streamlined Protocol for Developing a Clinicopathological Prediction Model for Patient Survival of Post-Resection of Pancreatic Cancer. [PDF]

Cancer Med
Ma Y, Lee E, Asadi K, Nikfarjam M, He H.
europepmc   +1 more source

Reviewer #2 (Public review): HIV-specific CD8+ T-cell responses soon after treatment initiation during acute HIV infection are associated with viral reservoir decline

Pien M van Paassen, Alexander O Pasternak, Karel A van Dort, Ad C van Nuenen, Irma Maurer, Brigitte Boeser-Nunnink, Ninée VEJ Buchholtz, Tokameh Mahmoudi, Cynthia Lungu, Reinout van Crevel, Casper Rokx, Jori Symons, Monique Nijhuis, Annelou van der Veen, Liffert Vogt, Michelle J Klouwens, Jan M Prins, Neeltje A Kootstra, Godelieve J de Bree, the Netherlands Cohort Study on Acute HIV Infection (NOVA) study team   +19 more
openalex   +1 more source

NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1/PD-L1 pathway 2537 [PDF]

Samantha Borys, Shanelle Reilly, Ian Magill, David Zemmour, Laurent Brossay   +4 more
openalex   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Downregulation of HLA Class I Expression through HLA-A DNA Methylation Is Associated with Reduced CD8+ T-cell Infiltration in Cervical Cancer. [PDF]

Cancer Immunol Res
Yoshimoto D, Iuchi H, Taguchi A, Sone K, Tamai K, Mori A, Kitamura S, Duong AQ, Ishizaka A, Kusakabe M, Yamamoto Y, Takase A, Ikemura M, Matsunaga H, Iriyama T, Kukimoto I, Kawazu M, Hamada M, Ushiku T, Oda K, Takeyama H, Hirota Y, Osuga Y.   +22 more
europepmc   +1 more source

Pentose phosphate pathway activity regulates TCF1+ progenitor CD8+ T cells to improve immunotherapy 4810 [PDF]

Geoffrey J. Markowitz, Bharati Swami, Vivek Mittal   +2 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis. [PDF]

Front Immunol
Rong X, Wang H, Muraoka S, Uehata T, Yoshinaga M, Kaisho T, Takeuchi O.   +6 more
europepmc   +1 more source