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Lack of the CD8+ cell anti-HIV factor in CD8+ cell granules
Blood, 2003AbstractIn HIV infection, CD8+ cells show cytotoxic and noncytotoxic anti-HIV activity. The latter function is mediated, at least in part, by a secreted antiviral protein, the CD8+ cell antiviral factor (CAF). Because antiviral effector molecules, such as perforin and granzymes, reside in the exocytic granules of CD8+ T cells, we examined the ...
Carl E, Mackewicz +5 more
openaire +2 more sources
The Journal of Immunology, 2017
Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge +19 more
openaire +1 more source
Abstract Autoimmune diseases such as type I diabetes (TID) and multiple sclerosis (MS) are chronic conditions that have a significant impact on quality of life. CD8+ T-cells play an important role in the pathogenesis of these diseases. However, drugs that target the entire CD8+ T-cell population are not desirable because this population ...
Linda Wooldridge +19 more
openaire +1 more source
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Nature, 2022Masao Hashimoto +2 more
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Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer
Cell, 2022Rodrigo Nalio Ramos +2 more
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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Cell, 2021Zeyu Chen, Omar Khan, Shin Foong Ngiow
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Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
Cell, 2022Jonas Lötscher +2 more
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