Results 221 to 230 of about 419,552 (297)

Study of Peripheral Blood T-Lymphocytes and Their Subpopulations in COVID-19 Patients. [PDF]

Biochem Res Int
Lin H, Yi J, Huang D, Wu J, Yin J.
europepmc   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

CD8⁺ T-NK cell crosstalk establishes preemptive immunosurveillance to eliminate antigen-escape tumors. [PDF]

Front Immunol
Uzhachenko RV, González Ochoa S, Kanagasabai T, Rajakaruna H, Thounaojam MC, de Aquino MTP, Rana T, Costa L, Terekhov A, Hofmeister WH, Sayers TJ, Boyer C, Ivanova AV, Goodwin JS, Schmitt-Verhulst AM, Shanker A.   +15 more
europepmc   +1 more source

Targeting Multilayered Metabolic Networks in Brain Diseases: Emerging Perspectives on Nanodelivery Strategies

Advanced Science, EarlyView.
Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley   +1 more source

Expansion of a circulating Ki67-positive effector T-cell population following combined PD-1 and CTLA-4 blockade for melanoma is predictive of treatment response. [PDF]

J Immunother Cancer
Edwards JM, Senthi S, Smith R, Burridge H, Owens C, Shackleton M, Andrews MC, van Zelm MC.   +7 more
europepmc   +1 more source

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

Major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins

, 1994
T C McGuire, Daniel B. Tumas, Katherine Byrne, Melissa T. Hines, S. R. Leib, A L Brassfield, Katherine I. O’Rourke, L E Perryman   +7 more
openalex   +1 more source

Progenitor-exhausted T cell as prognostic indicator in esophageal squamous cell carcinoma: illuminating their key contribution to tumor immunity. [PDF]

Front Immunol
Liu Y, Jiang H, Fang Z, Xu B, Chen J, Zheng X, Geng R, Chen L.   +7 more
europepmc   +1 more source

STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer

Advanced Science, EarlyView.
This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao, Pu Xing, Hao Hao, Jiangbo Chen, Lin Song, Yifan Hou, Xinying Yang, Kai Weng, Jie Chen, Pin Gao, Tongkun Song, Hong Yang, Tianqi Liu, Yumeng Ran, Bo Chen, Wei Zhao, Jiabo Di, Zaozao Wang, Jun Zhang, Xiangqian Su, Beihai Jiang   +20 more
wiley   +1 more source

Integrin CD103 expression in naive CD8⁺ T cells promotes cytokine-driven acquisition of memory phenotype and effector function. [PDF]

Immunity
Li C, Ligons DL, Lanasa D, Keller HR, Luckey MA, Capaldo B, Meerzaman D, Park JY, Park JH.   +8 more
europepmc   +1 more source