Results 221 to 230 of about 436,454 (294)

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Dimethyl itaconate suppresses dendritic cell and CD8⁺ T cell responses to halt vitiligo. [PDF]

BMC Med
Wang Y, Chen Y, Ma J, Wu L, Kang P, Chen J, Du P, Wu W, Wang X, He K, Yang Y, Guo S, Guo W, Liu L, Jian Z, Gao T, Li S, Li C.   +17 more
europepmc   +1 more source

CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation

, 2006
Christian O. Simon, Rafaela Holtappels, Hanna-Mari Tervo, Verena Böhm, Torsten Däubner, Silke A. Oehrlein-Karpi, Birgit Kühnapfel, Angélique Renzaho, Dennis Strand, Jürgen Podlech, Matthias J. Reddehase, Natascha K. A. Grzimek   +11 more
openalex   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control. [PDF]

Inflamm Regen
Guo Q, Zhang C, Wang B, Iriguchi S, Ishikawa A, Minagawa A, Ishii T, Kawai Y, Kaneko S.   +8 more
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

HLA-DR+ CD8+ T lymphocytes as an alternative T-cell activation marker in pediatric HLH: A real-life study. [PDF]

Pediatr Allergy Immunol
Triaille C, Fernandez I, Touzot F.
europepmc   +1 more source

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Peripheral blood immune cell profiling and response to BCMA CAR-T cell therapy in relapsed refractory multiple myeloma. [PDF]

Blood Cancer J
Pandey T, Mohan Lal B, Alrawabdeh J, Alzu'bi M, Schinke CD, Thanendrarajan S, Alapat DV, Shaughnessy JD, Zhan F, Zangari M, van Rhee F, Al Hadidi S.   +11 more
europepmc   +1 more source

Hand in hand to successful immunotherapy: CD8+ T cells and M1-like macrophages swap the baton [PDF]

Abir Hussein, Slava Stamova, Maria Xydia, Philipp Beckhove   +3 more
openalex   +1 more source