Results 231 to 240 of about 922,724 (383)

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Nature, 2019
Caroline S. Jansen, Nataliya Prokhnevska, V. Master, M. Sanda, J. Carlisle, M. Bilen, M. Cardenas, S. Wilkinson, Ross Lake, A. Sowalsky, R. Valanparambil, W. Hudson, D. McGuire, K. Melnick, A. I. Khan, K. Kim, Y. Chang, Alice Kim, C. Filson, M. Alemozaffar, A. Osunkoya, Patrick Mullane, C. Ellis, Rama S. Akondy, S. Im, A. Kamphorst, A. Reyes, Yuan Liu, H. Kissick   +28 more
semanticscholar   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice

, 2020
Jayagopi Surendar, Karunakaran Indulekha, Stefan J. Frohberger, Marianne Koschel, Achim Hoerauf, Marc P. Hübner   +5 more
openalex   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, EarlyView.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source

Reduced apoptosis of CD8+ T-Lymphocytes in the airways of smokers with mild/moderate COPD

, 2011
Liboria Siena, Mark Gjomarkaj, John Elliot, Elisabetta Pace, Andreina Bruno, Simonetta Baraldo, Marina Saetta, Maria R. Bonsignore, Anthony James   +8 more
openalex   +2 more sources

SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues [PDF]

, 2019
Carly E. Starke, Carol L. Vinton, Kristin Ladell, James E. McLaren, Alexandra M. Ortiz, Joseph C. Mudd, Jacob K. Flynn, Stephen H. Lai, Fan Wu, Vanessa M. Hirsch, Samuel Darko, Daniel C. Douek, David A. Price, Jason M. Brenchley   +13 more
openalex   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

FXR-mediated antigen-specific CD8⁺ T cell enhances antitumor immunity in intrahepatic cholangiocarcinoma. [PDF]

J Immunother Cancer
Liu S, Liang Z, Zhu L, Zheng Y, Yu H, Ye S, Liang T, Huang L, Ouyang J, Cao Y, Ye L, Ye L.   +11 more
europepmc   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

NEAT1 is a therapeutic target for reversing T-cell exhaustion in bladder cancer. [PDF]

J Immunother Cancer
Li K, Niu L, Zhang X, Li T, Zhou X, Wang L, Han J, Wang Z.   +7 more
europepmc   +1 more source