Results 231 to 240 of about 419,552 (297)

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

Advanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu, Liting Huang, Suzhen Bi, WeiKaixin Kong, Wanting Feng, Yingjia Li, Zhengwei Xie, Peipei Shan, Sujie Zhu   +8 more
wiley   +1 more source

Faithful modeling of terminal CD8+T cell dysfunction and epigenetic stabilization in vitro. [PDF]

JCI Insight
Yousif A, Saadey AA, Lowin A, Yousif AM, Saini A, Allison MR, Ptak K, Oltz EM, Ghoneim HE.   +8 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Plasmacytoid and CD141+ Myeloid Dendritic Cells Cooperation with CD8+ T Cells in Lymph Nodes is Associated with HIV Control. [PDF]

MedComm (2020)
Vitallé J, Bachiller S, Dominguez-Molina B, Moysi E, Ferrando-Martínez S, Camacho-Sojo MI, Gallego I, Pérez-Gómez A, Jiménez-Leon MR, Gasca-Capote C, Ostos FJ, Rafii-El-Idrissi Benhnia M, Via LE, Mochón A, López-Cortes LF, Petrovas C, Koup RA, Ruiz-Mateos E.   +17 more
europepmc   +1 more source

Nanographene Oxide Attenuates Acute GVHD by Modulating Macrophage Polarization in a Xenogeneic Mouse Model

Advanced Science, EarlyView.
Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu, Hyun Sung Park, Dong‐Hoon Chae, Jae Han Park, Jiyoung Heo, Keonwoo Cho, Jiho Kim, Hyewon Lee, Sueyeon Jee, Chanwoo Kim, Soon Won Choi, Jaechul Ryu, Eun‐Hye Hur, Yunsuk Choi, Eun‐Ji Choi, Mi‐Kyung Oh, Hwa‐Yong Lee, Je‐Hwan Lee, Kyung‐Rok Yu   +18 more
wiley   +1 more source

Correlation Between the Proportion of Senescence-Associated β-Galactosidase-Stained CD8+ T Cells and Age: A Cross-Sectional Study in Japan. [PDF]

Int J Mol Sci
Tsubokawa M, Shimizu Y, Yazaki M, Shimodan S, Noguchi M, Yamazaki A, Watanabe T, Ocho M, Sakurada T, Hirose Y, Saito J, Ishii Y.   +11 more
europepmc   +1 more source

Microwave‐Activated Bacterial Biorobot for Multimodal Cancer Therapy

Advanced Science, EarlyView.
An Escherichia coli bacterial biorobot is engineered for localized microwave activation in cancer therapy. Upon activation at tumor sites, the biorobot releases glucose oxidase, inducing tumor cell death via glucose depletion and H2O2 generation catalyzed by Cu2O.
Huilan Zhuang, Yongjian Zhang, Yajuan Fu, Dangjin Ke, Qi Chen, Sijie Shao, Panpan Xue, Yuanchun Chen, Xuemei Zeng, Shuangqian Yan   +9 more
wiley   +1 more source

Microbial metabolite facilitates virus control: inosine and T cells curb early-life influenza infection. [PDF]

Signal Transduct Target Ther
Sevenich L, Le TT, Mager LF.
europepmc   +1 more source

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advanced Science, EarlyView.
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang, Fuwei Li, Lin Lv, Zhenfan Wen, Zhongren Xu, Yixia Yang, Chunyang Bi, Wukun Liu   +10 more
wiley   +1 more source

Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis. [PDF]

Int J Mol Sci
Kumar V.
europepmc   +1 more source