Results 241 to 250 of about 394,438 (273)

Characterizing HLA-A2-restricted CD8⁺ T-cell epitopes and immune responses to Omicron variants in SARS-CoV-2-inactivated vaccine recipients. [PDF]

Front Immunol
Xiao C, Xiang J, Wang H, Gao W, Peng T, Li S, Su J, Chen X, Gao L, Shi R, Mou X, Yuan J, Chen G.   +12 more
europepmc   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye   +12 more
wiley   +1 more source

Heterogeneity of T cells regulates tumor immunity mediated by Helicobacter pylori infection in gastric cancer. [PDF]

BMC Cancer
Wu Z, Wang X, Shi S, Kong D, Ren C, Bian L, Gu Y, An F, Zhan Q, Yan C, Hu C, Chen Y, Jiang R, Chen J.   +13 more
europepmc   +1 more source

Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy

Advanced Science, EarlyView.
This work develops a cyanine dye named Cy‐BF and encapsulates it with phospholipids and platelet exosome vesicles to create CHL. Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation‐induced broadening of absorption spectra and NIR‐activated photothermal therapy and type I photodynamic ...
Yongjian Zhang, Xiaohong Wu, Kaiyuan Wang, Yaohan Tang, Xiuxin Lu, Fusheng Sun, Hua Tang, Xiaoyuan Chen, Shipeng Ning   +8 more
wiley   +1 more source

Distinct immune memory induced by SARS-CoV-2 in convalescent liver transplant recipients. [PDF]

Front Immunol
Liu M, Wu F, Duan B, Zhang Y, Wang W, Chen Z, Sun Y, Zhang G, Wang Y, Sun Y, Ouyang Y, Li G.   +11 more
europepmc   +1 more source

An optimal viral peptide recognized by CD8+ T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein.

, 1991
Theodore J. Tsomides, Bruce D. Walker, H N Eisen   +2 more
openalex   +1 more source

IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8+ T Cell Activation to Aggravate Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
This study highlights the critical role of IRF8 in the development of AAA. IRF8 activation promotes the differentiation of cDC1s, which in turn recruit and activate CD8+ T cells, contributing to aortic wall degradation. The study identifies the IRF8‐cDC1‐CD8+ T cell axis as a key pathway in AAA progression, offering new potential therapeutic targets to
Zhen Yuan, Li Shu, Yidan Zheng, Yidong Wang, Mengsha Zheng, Jie Sun, Jiantao Fu, Zihao Zhou, Shen Song, Zhenjie Liu, Fei Li, Zhejun Cai   +11 more
wiley   +1 more source

Immune cell phenotypes as causal factors in liver disease progression revealed by Mendelian randomization. [PDF]

Sci Rep
Huang J, Zou W, Lv Z, Han H, Huang J, Su H.   +5 more
europepmc   +1 more source

Implanted Microneedles Loaded with Sparfloxacin and Zinc‐Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple‐Negative Breast Cancer to Prevent Recurrence and Metastasis

Advanced Science, EarlyView.
Hyaluronic acid Microneedles (MNs) are loaded with Sparfloxacin (SP) and zinc‐manganese sulfide (ZMS) for the postoperative in situ treatment of triple‐negative breast cancer (TNBC) to prevent cancer recurrence and combat wound infection. These microneedles enhance antitumor immunity by activating the cGAS‐STING pathway, suppress tumor growth, reduce ...
Zhaoyou Chu, Wang Zheng, Wanyue Fu, Jun Liang, Wanni Wang, Lingling Xu, Xiaohua Jiang, Zhengbao Zha, Haisheng Qian   +8 more
wiley   +1 more source

Acasunlimab, an Fc-inert PD-L1×4-1BB bispecific antibody, combined with PD-1 blockade potentiates antitumor immunity via complementary immune modulatory effects. [PDF]

J Immunother Cancer
Capello M, Sette A, Plantinga T, Thalhauser CJ, Spires VM, Nürmberger KB, Blum JM, Higgs BW, Garrido Castro P, Yu C, Costa Sa C, Fellermeier-Kopf S, Burm SM, Strumane K, Toker A, Imle A, de Andrade Pereira B, Muik A, Ahmadi T, Türeci Ö, Fereshteh M, Sahin U, Jure-Kunkel M, Pencheva N.   +23 more
europepmc   +1 more source