Results 241 to 250 of about 436,454 (294)

Figure S1 from Tumor-Infiltrating CD103⁺ Tissue-Resident Memory T Cells and CD103⁻CD8⁺ T Cells in HNSCC Are Linked to Outcome in Primary but not Metastatic Disease

Adrian von Witzleben, Matthew J. Ellis, Gareth J. Thomas, Thomas K. Hoffmann, Richard Jackson, Simon Laban, Christian H. Ottensmeier   +6 more
openalex   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Rewiring Dendritic Cell Immunity: The β-Catenin-TIM-3 Axis as a Target to Improve DC Cancer Vaccines. [PDF]

Cancers (Basel)
Fu C, Ma T, Zhou L, Mi QS, Jiang A.
europepmc   +1 more source

eLife Assessment: PIM kinase control of CD8 T cell protein synthesis and cell trafficking

Michael L. Dustin
openalex   +1 more source

NAD+‐Dependent Enzyme SIRT3 Limits Intestinal Epithelial Cell Functions Through NAD+ Synthesis Pathway in Colorectal Cancer

Advanced Science, EarlyView.
Microbiota‐derived quinolinic acid is used as an alternative source of replenishing the intracellular NAD+ pool induced by SIRT3 deficiency to regulate intestinal epithelial cell and T cell function, which has implications for targeting intestinal epithelial cells as an approach to the treatment of immune‐associated diseases, including colorectal ...
Ruiying Niu, Yingjie Dong, Jianghui Tong, Jingxuan Xia, Longhao Zhao, Zi Geng, Yingxin Lin, Jinghe Zhang, Xinyi Liu, Manqi Fang, Xi Jin, Yujing Bi, Guangwei Liu   +12 more
wiley   +1 more source

Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity. [PDF]

Sci Adv
Castillo JG, Silveria S, Schirokauer L, Sauquet A, Hung J, Jaworski G, Hendricks JM, Sul HS, Olzmann JA, DuPage M.   +9 more
europepmc   +1 more source

Expanded senescent CD8 T cells in IMID patients are associated with distinct inflammatory cytokines

Marie Naigeon, Samuel Bitoun, Matthieu Roulleaux Dugage, Caroline de Oliveira, Caroline Berthot, Benjamin Besse, Aurélien Marabelle, F.X. Danlos, Xavier Mariette, Nathalie Chaput, Gaëtane Nocturne   +10 more
openalex   +2 more sources

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Innate CD8 T-cells as a potential predictive biomarker for deep molecular response in chronic myeloid leukemia patients. [PDF]

Cancer Immunol Immunother
Cayssials E, Lefèvre L, Decroos A, Jacomet F, Piccirilli N, Tartarin F, Guilhot F, Chomel JC, Rousselot P, Nicolini FE, Ragot S, Gombert JM, Roy L, Herbelin A, Barbarin A.   +14 more
europepmc   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenkel, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source