Results 31 to 40 of about 883,722 (384)

CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients.

Journal of Clinical Investigation, 2016
BACKGROUND T cells that have been modified to express a CD19-specific chimeric antigen receptor (CAR) have antitumor activity in B cell malignancies; however, identification of the factors that determine toxicity and efficacy of these T cells has been ...
C. Turtle, L. Hanafi, C. Berger, T. Gooley, S. Cherian, M. Hudecek, D. Sommermeyer, Katherine Melville, B. Pender, Tanya M Budiarto, E. Robinson, Natalia N Steevens, Colette N. Chaney, L. Soma, Xueyan Chen, C. Yeung, B. Wood, Daniel H. Li, Jianhong Cao, S. Heimfeld, M. Jensen, S. Riddell, D. Maloney   +22 more
semanticscholar   +1 more source

Contrasted TCRβ Diversity of CD8+ and CD8− T Cells in Rainbow Trout

PLoS ONE, 2013
Teleost fish express highly diverse naive TCRβ (TRB) repertoires and mount strong public and private clonal responses upon infection with pathogens. Fish T cells express typical markers such as CD8, CD4-1 and CD4-2, CD3, CD28 and CTLA4. Fish CD8(+) T cells have been shown to be responsible for antigen-specific cell-mediated cytotoxicity in in vitro ...
Castro, Dona Maria Rosario, Takizawa, Fumio, Chaara, Wahiba, Lunazzi, Aurélie, Dang, Thi Huong, Koellner, Bernd, Quillet, Edwige, Six, Adrien, Fischer, Uwe, Boudinot, Pierre   +9 more
openaire   +9 more sources

CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial

OncoImmunology, 2017
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS).
Anne Gomez-Brouchet, Claire Illac, Julia Gilhodes, Corinne Bouvier, Sébastien Aubert, Jean-Marc Guinebretiere, Béatrice Marie, Frédérique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Thomas Filleron, Véronique Minard, Vincent Minville, Eric Mascard, François Gouin, Marta Jimenez, Marie-Cécile Ledeley, Sophie Piperno-Neumann, Laurence Brugieres, Françoise Rédini   +19 more
doaj   +1 more source

ROLE OF CD95 AND DR3 RECEPTORS IN NA VE T-LYMPHOCYTES APOPTOSIS IN CHILDREN WITH INFECTIOUS MONONUCLEOSIS DURING CONVALESCENCE

Инфекция и иммунитет, 2017
Infectious mononucleosis is a widespread disease caused by certain members of Herpesviridae family. Acute infectious mononucleosis develops predominantly in children and is accompanied by an increase of the number of circulating naive CD4+ and naive CD8+
E. N. Filatova, E. V. Anisenkova, N. B. Presnyakova, E. A. Kulova, O. V. Utkin   +4 more
doaj   +1 more source

CD8+ and CD8- NKT Cells Exhibit Phenotypic Changes During Pregnancy

Immunological Investigations, 2022
NKT cell population is a relatively well-characterized immune cell subset. Numerous publications have characterized the phenotypical features of its subpopulations even in human pregnancy. Nevertheless, there have not been studies investigating the distribution of the NKT cells based on the surface presence of the CD8 receptor.
Matyas Meggyes, David U. Nagy, Iyad Saad Al Deen, Borbala Parkanyi, Laszlo Szereday   +4 more
openaire   +3 more sources

Schopenhauer and I. Kant in A. A. Fet’s philosophical and political worldview (conclusion) [PDF]

Кантовский сборник, 2013
The concluding part of the work focuses on the independence of A. A. Fet’s philosophical worldview strongly emphasised by the poet himself and his close friends. Although he quotes Schopenhauer and Kant, he criticised them and demonstrates an independent
Kalinnikov L.
doaj   +1 more source

Abnormal distribution of CD8 subpopulation in B-chronic lymphocytic leukemia identified by flow cytometry [PDF]

, 1988
We studied the occurrence of T-cell subpopulations for patients with B-cell chronic lymphocytic leukemia. The CD8+ population was divided into CD8+ suppressor (CD8a+) and CD8+ cytotoxic (CD8b+) lymphocytes using difference in orthogonal light scattering.\
B.G.De Grooth, Bloem, C.H.H. Ten Napel, Catovsky, Chiokazzi, Deegan, Dickinson, Foa, Foa, Foa, Heurmann, Inoshita, J. Greve, Kay, Kay, Knapp, L.W.M.M. Terstappen, Lauria, Mankey, Mills, Mittelman, Nicholson, Platsoucas, Platsoucas, Rai, Sieber, Terstappen, Terstappen, Velardi, W. van Berkel, Worman   +30 more
core   +2 more sources

CD8 is required during positive selection of CD4-/CD8+ T cells. [PDF]

The Journal of experimental medicine, 1990
Interactions between self-MHC molecules and T cells are necessary for the proper development of mature T cells, in part due to an absolute requirement for self-MHC-TCR interactions. Recently, we showed that CD4-mediated interactions also participate in shaping the T cell repertoire during thymic maturation.
Juan Carlos Zúñiga-Pflücker, Ada M. Kruisbeek, L A Jones, Dan L. Longo   +3 more
openaire   +3 more sources

Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC

Molecular Cancer, 2021
CD8+ T cells play a critical role in the innate antitumour immune response. Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC).
Shi-wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jianjun Xu, Yongbing Wu   +9 more
semanticscholar   +1 more source

CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]

, 2018
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core   +2 more sources