Results 31 to 40 of about 419,552 (297)

CD8+ CD28− and CD8+ CD57+ T cells and their role in health and disease

Immunology, 2011
Chronic antigenic stimulation leads to gradual accumulation of late-differentiated, antigen-specific, oligoclonal T cells, particularly within the CD8(+) T-cell compartment. They are characterized by critically shortened telomeres, loss of CD28 and/or gain of CD57 expression and are defined as either CD8(+) CD28(-) or CD8(+) CD57(+) T lymphocytes ...
Marius Strioga, Dainius Characiejus, Vita Pasukoniene   +2 more
openaire   +4 more sources

Case Report: Early presentation of hereditary angioedema symptoms in a 2-year-old boy

Frontiers in Pediatrics
Hereditary angioedema (HAE) is a rare autosomal-dominant disease that is caused by a deficiency (type I) or dysfunction (type II) of the C1 inhibitor (C1-INH) due to a mutation in the SERPING1 gene, which codes for C1-INH.
Jurate Staikuniene-Kozonis, Jurate Staikuniene-Kozonis, Juste Staikunaite, Juste Staikunaite, Edita Gasiuniene, Justina Sematonyte   +5 more
doaj   +1 more source

Inflaming the CD8+ T Cell Response [PDF]

Immunity, 2006
Although inflammatory cytokines induced by infection or vaccination with adjuvants have long been known to stimulate optimal antigen-presenting cell function, recent evidence indicates that some inflammatory cytokines also act directly on the responding T cells to control their response to infection.
Vladimir P. Badovinac, Jodie S. Haring, John T. Harty   +2 more
openaire   +3 more sources

Brain Autoimmunity: The CD8 Question(s) [PDF]

Immunity, 2012
In this issue of Immunity, Na et al. (2012) show that the purging of central nervous system (CNS)-specific CD8(+) T cell repertoire requires direct contact with antigen expressing oligodendrocytes and inflammation tips the balance toward autoimmunity.
Hartmut Wekerle, Gurumoorthy Krishnamoorthy   +1 more
openaire   +3 more sources

Distribution of melanocytes in the skin of psoriasis patients

Vestnik Dermatologii i Venerologii, 2019
Psoriasis is a chronic immune-mediated inflammatory disease with predominant damage to the skin and joints. Despite fundamental studies of its pathogenesis, the cause of the development of the T-cell response has not been determined. More recently, a new
A. S. Zhukov, V. R. Khairutdinov, I. E. Belousova, A. V. Samtsov   +3 more
doaj   +1 more source

Dichotomy of two CD8+ lymphocyte subsets in HIV infection. Depletion of CD8+ CD3- and expansion of CD8+ CD3+ subsets: consequence on the CD4/CD8 ratio

Clinical and Experimental Immunology, 1991
SUMMARYIn order to highlight the underlying mechanism(s) of the CD8 lymphocyte expansion in the HIV infection, two distinct CD8 subsets were analysed: T CD8bright+ CD3+ with MHC-restricted activity, and non-T CD8dim+ CD3-, which performs natural killer (NK) activity.
C. Doinel, Philippe Rouger, Issam Mansour   +2 more
openaire   +4 more sources

Imaging the Effector CD8 Synapse [PDF]

, 2017
Here, we describe 4D imaging of effector CD8+ T cells as they conjugate and kill live targets in vitro and analyze the polarization dynamics of intracellular compartments to this cell-cell interface.
Frazer, Gordon L, Asano, Yukako, Griffiths, Gillian M   +2 more
openaire   +2 more sources

Defining Memory CD8 T Cell [PDF]

Frontiers in Immunology, 2018
CD8 T cells comprising the memory pool display considerable heterogeneity, with individual cells differing in phenotype and function. This review will focus on our current understanding of heterogeneity within the antigen-specific memory CD8 T cell compartment and classifications of memory CD8 T cell subsets with defined and discrete functionalities ...
Matthew D. Martin, Vladimir P. Badovinac, Vladimir P. Badovinac, Vladimir P. Badovinac   +3 more
openaire   +3 more sources

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

OncoImmunology, 2018
Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen, Walter Olson, Nolan A. Wages, Brian J. Capaldo, Ileana S. Mauldin, Adela Mahmutovic, Ciara Hutchison, Cornelis J.M. Melief, Timothy N. Bullock, Victor H. Engelhard, Craig L. Slingluff   +10 more
doaj   +1 more source

Peripheral Tolerance of CD8 T Lymphocytes [PDF]

Immunity, 2005
Whereas high-avidity recognition of peptide-MHC complexes by developing T cells in the thymus results in deletion and promotes self-tolerance, such recognition by mature T cells in the periphery results in activation and clonal expansion. This dichotomy represents the basis of a dilemma that has stumped immunologists for many years, how are self ...
Linda A. Sherman, William L. Redmond
openaire   +3 more sources