Results 101 to 110 of about 93,479 (280)

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Costimulatory molecule-deficient dendritic cell progenitors (MHC class II⁺, CD80(dim), CD86^-) prolong cardiac allograft survival in nonimmunosuppressed recipients [PDF]

, 1996
We have shown previously that granulocyte-macrophage colony-stimulating factor-stimulated mouse bone marrow-derived MHC class II+ dendritic cell (DC) progenitors that are deficient in cell surface expression of the costimulatory molecules B7-1 (CD8O) and
Angus W. Thomson, Azuma, Boussiotis, Boussiotis, Clare-Salzler, Demetris, Frances Chambers, Freeman, Freeman, Fumin Fu, Gimmi, Go, Hathcock, Inaba, Inaba, Inaba, Jenkins, Jenkinson, John J. Fung, Khoury, Kraal, Larsen, Lin, Lina Lu, Linsley, Lu, Lu, Lu, Lu, Matzinger, Pearson, Qian, Rastellini, Reis e Sousa, Sakamoto, Sayegh, Shiguang Qian, Starzl, Starzl, Steinman, Swiggard, Talmor, Taniguchi, Thomas E. Starzl, Thomson, Turka, Van Gool, Woo, Youping Li   +48 more
core   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

PERBEDAAN EKSPRESI CLUSTER OF DIFFERENTIATION 80 (CD80) DAN CLUSTER OF DIFFERENTIATION 86 (CD86) PADA KARSINOMA NASOFARING TIPE UNDIFFERENTIATED STADIUM III DAN IV [PDF]

, 2016
Latar Belakang : Karsinoma nasofaring (KNF) merupakan tumor ganas lapisan epitel nasofaring. Pada respon imun,ikatan molekul kostimulatori CD80, CD86 dan CD28 dikenal sebagai signal 2, yang mengakibatkan sel T teraktifasi. Tujuan : Menganalisis perbedaan
Suhana, Nanang
core  

Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming [PDF]

, 2015
Foxp3(+) regulatory T cells (Tregs) maintain immune homoeostasis through mechanisms that remain incompletely defined. Here by two-photon (2P) imaging, we examine the cellular dynamics of endogenous Tregs.
Cahalan, Michael D, Deswarte, Kim, Dong, Tobias X, Greenberg, Milton L, Hammad, Hamida, Lambrecht, Bart, Matheu, Melanie, Othy, Shivashankar, Parker, Ian, Schuijs, Martijn   +9 more
core   +3 more sources

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Research progress of CD80 in the development of immunotherapy drugs

Frontiers in Immunology
CD80 is a molecule that plays an important role in the immune system, especially during T-cell activation, and its ligands are mainly CD28, PD-L1, and CTLA-4.
Lanying Li, Lei Yang, DePeng Jiang
doaj   +1 more source

Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]

, 2019
Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus, Buttgereit, Frank, Duda, Georg N., Fiedler, Alexander F., Gaber, Timo, Hauser, Anja E., Köhler, Markus, Lang, Annemarie, Niesner, Raluca A., Rauch, Ariana, Schmidt-Bleek, Katharina, Stefanowski, Jonathan   +11 more
core   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity

eLife, 2020
Focal Adhesion Kinase (FAK) inhibitors are currently undergoing clinical testing in combination with anti-PD-1 immune checkpoint inhibitors. However, which patients are most likely to benefit from FAK inhibitors, and what the optimal FAK/immunotherapy ...
Marta Canel, David Taggart, Andrew H Sims, David W Lonergan, Irene C Waizenegger, Alan Serrels   +5 more
doaj   +1 more source