Results 91 to 100 of about 65,297 (255)

17p deletion , CD 80 and CD 86 expression in chronic lymphocytic leukemia [PDF]

Minia Journal of Medical Research
Background: In chronic lymphocytic leukemia (CLL), monoclonal B cells proliferate within pseudofollicular proliferation centers. Unlike healthy B cells, leukemic cells are poor antigen-presenting cells due to decreased expression of costimulatory ...
Reem Elgarhy, Aliaa Abd El-Fatah, Nada Sholkamy, Mostafa Elsayed Abuelela, Waleed AbdelHamid, Khaled Salah, Nagwa Okaily   +6 more
doaj   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Predictability of Urinary CD80 in the Relapse of Primary Nephrotic Syndrome [PDF]

, 2017
Purpose. The current study is aimed at investigating whether urinary CD80 is reliable to predict the recurrence of pediatric PNS. Materials and Methods. A total of 128 children, 105 males and 23 females, were enrolled in this study.
Can-Lin Li, Lan-Jun Shuai, Juan Liao, Qia Cheng, Yan Cao, Xiao-Chuan Wu, Zhu-Wen Yi   +6 more
core   +1 more source

Biomimetic Macrophage Cell Membrane‐Based Nanoparticles for Effective Treatment of Glioblastoma Through Boron Neutron Capture Therapy Combined With Immunotherapy

Advanced Science, EarlyView.
ABSTRACT Glioblastoma multiforme (GBM) remains largely incurable due to the blood‐brain barrier (BBB) and immunosuppressive microenvironment. While boron neutron capture therapy (BNCT) selectively eradicates tumor cells via 10B(n, α)‐7Li reactions, its clinical potential in GBM is unrealized because of the suboptimal pharmacokinetics of conventional ...
Jiawen Chen, Haoyu You, Hefa Huang, Huihui Chai, Ruize Zhu, Yun Guan, Qisheng Tang, Tianwen Li, Shan Jiang, Houshi Xu, Peng Wang, Yue Wang, Maoyuan Sun, Beining Liu, Zhen Li, Yulai Zeng, Weiqiu Ping, Yanlin Teng, Songlin Yan, Qinghui Li, Long Gu, Tao Sun, Zhifeng Shi   +22 more
wiley   +1 more source

Eye‐Brain Neuroimmune Axis Enables Long‐Term Survival in Glioblastoma by Modulating Brain Immune Surveillance and Neuronal Excitability

Advanced Science, EarlyView.
The eye–brain neuroimmune axis triggers immune activation and disrupts pathological neuronal connectivity to extend glioblastoma survival. ABSTRACT As an anatomical extension of the central nervous system (CNS), the eye harbors rich neural and immune interfaces with the brain. However, the integrated immunological and neurological nexus between the eye
Mingyue Cui, Lulu Qian, Binbin Chu, Xuan Qin, Menglin Wu, Minke Wu, Tongyu He, Baochuan Zhang, Bin Song, Yao He   +9 more
wiley   +1 more source

Mucosal immune environment in colonic carcinogenesis: CD80 up-regulation in colonic dysplasia in ulcerative colitis [PDF]

, 2011
: Background: In patients with ulcerative colitis (UC) the inconsistency between the rate of dysplasia and actual cancer incidence suggests the presence of an immunosurveillance mechanism.
RUFFOLO C, NAVAGLIA F, PLEBANI, MARIO, FAGGIAN D, D'INCA R, SCARPA M, STURNIOLO, GIACOMO, POZZA A, BORTOLAMI, MARINA, CECCHETTO, ATTILIO, ANGRIMAN, IMERIO, KOTSAFTI, ANDROMACHI   +11 more
core   +1 more source

Recombinant CD80 fusion protein combined with discoidin domain receptor 1 inhibitor for cancer treatment

Applied Microbiology and Biotechnology
Immune checkpoint inhibitors (ICIs) have significantly advanced the field of cancer immunotherapy. However, clinical data has shown that many patients have a low response rate or even resistance to immune checkpoint inhibitor alone.
Songna Wang, Pinliang Hu, Xuyao Zhang, Jiajun Fan, Jing Zou, Weidong Hong, Xuan Huang, Danjie Pan, Huaning Chen, Dianwen Ju, Yi Zhun Zhu, Li Ye   +11 more
doaj   +1 more source

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma

BMC Cancer, 2007
Background B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of ...
Lin Hsuan-Yu, Hsu Nicholas C, Chang Julia H, Chang Cheng-Shyong, Chung Chih-Yuan   +4 more
doaj   +1 more source

Nano‐Confined Radical Anion as An NIR‐II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination

Advanced Science, EarlyView.
A nano‐confined radical anion acts as a photothermal immunogenic amplifier. Kinetically stabilized nanoparticles couple high near‐infrared‐II (NIR‐II) photothermal efficacy with glutathione (GSH) depletion to boost reactive oxygen species (ROS) and immunogenic cell death (ICD).
Mengxin Mu, Mengyu Guo, Jun Guan, Xiaofeng He, Mingdi Hu, Fene Gao, Klaus Müllen, Chendong Ji, Chunying Chen, Meizhen Yin   +9 more
wiley   +1 more source

Differential requirement for CD80 and CD80/CD86-dependent costimulation in the lung immune response to an influenza virus infection [PDF]

The CD28 costimulatory pathway is critical to T cell activation. Blockade of the interaction of CD28 with its ligands CD80 and CD86 using CTLA4-Ig has been proposed as a therapy for a number of immune-based disorders.
Harris, N. L., Roberts, J. M., Peach, R. J., Lumsden, J. M., Ronchese, F.   +4 more
core   +1 more source