Results 101 to 110 of about 65,297 (255)

FLT3-ITD promotes immune checkpoint CD80 via ROS elevation in acute myeloid leukemia

Frontiers in Immunology
Acute myeloid leukemia (AML), a malignant hematological stem cell disease, arises from the malignant transformation of myeloid progenitor cells. Among the genetic aberrations in AML, mutations in the tyrosine kinase receptor FLT3, especially FLT3-ITD ...
Libo Yan, Weiming Zhang, Qiyan Mo, Daogang Wang, Ning Xu, Mengzhe Yang, Tao Ren   +6 more
doaj   +1 more source

CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers

International Journal of Endocrinology, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance.
Chiara Tuccilli, Enke Baldini, Salvatore Sorrenti, Antonio Catania, Alessandro Antonelli, Poupak Fallahi, Francesco Tartaglia, Susi Barollo, Caterina Mian, Andrea Palmieri, Giovanni Carbotta, Stefano Arcieri, Daniele Pironi, Massimo Vergine, Massimo Monti, Salvatore Ulisse   +15 more
doaj   +1 more source

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

Allergens and Irritants Transcriptionally Upregulate CD80 Gene Expression in Human Keratinocytes [PDF]

, 2000
The human CD80 costimulatory molecule is an important signal between professional antigen-presenting cells and T helper cells. The immunobiology of CD80 expression by keratinocytes, especially during allergic and irritant contact dermatitis, however, is ...
Gaspari, Anthony A., Zlotnick, David, Haidaris, Constantine G., Wakem, Paul, Burns, Robert P., Ferbel, Barbara, Ramirez, Francisco   +6 more
core   +1 more source

Material‐Encoded Synchronization of Immunogenic Cell Death With Adenosine A2A Receptor Blockade Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
A bismuth–copper diselenide–based nanoplatform (BSCS@PHY) coordinates immunogenic cell death with local A2A receptor blockade in 4T1 tumors. Thermally triggered shell melting exposes catalytic surfaces for glutathione depletion and chemodynamic ROS generation, while co‐delivering an A2AR antagonist and yeast‐wall adjuvant to enhance dendritic‐cell ...
Xiangting Yi, Hanlou Yang, Junting Huang, Pengfei Wu, Shiying Zhou, Zunde Liao, Min Han, Zishan Chen, Xiaoyu Huang, Nan Ma, Jie Zhou, Mingqiang Li, Yiling Zhong   +12 more
wiley   +1 more source

Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease [PDF]

, 2008
Background: Human inflammatory bowel disease (IBD) is a chronic condition mediated by aberrant immune responses to the luminal antigens by activated CD4+ T cells.
Summerlin, D (15537056), Srinivasan, M (15537059), Rajaraman Eri (14736106), Kodumudi, N (15537053)   +3 more
core  

Expression of costimulatory molecules in the bovine corpus luteum

Reproductive Biology and Endocrinology, 2007
Background Bovine luteal parenchymal cells express class II major histocompatibility complex (MHC) molecules and stimulate class II MHC-dependent activation of T cells in vitro. The ability of a class II MHC-expressing cell type to elicit a response from
Pate Joy L, Davis John S, Cannon Matthew J   +2 more
doaj   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

LPS REMOVAL REDUCES CD80-MEDIATED ALBUMINURIA IN CRITICALLY ILL PATIENTS WITH GRAM-NEGATIVE SEPSIS [PDF]

, 2019
LPS-induced sepsis is a leading cause of acute kidney injury (AKI) in critically ill patients. LPS may induce CD80 expression in podocytes with subsequent onset of proteinuria, a risk factor for progressive chronic kidney disease (CKD) frequently ...
Prattichizzo C., Godeas, Giulia, Castellano, Giuseppe, Spadaccino, Federica, Cotoia A., Sangregorio, Fabio, Stallone, Giovanni, Crovace A., Staffieri F., Infante B., Staffieri, Francesco, Stallone G., MAIORANO, ANNAMARIA, Ranieri E., Netti, Giuseppe Stefano, Cinnella, Gilda, Ranieri, Elena, Grandaliano, Giuseppe, Gesualdo L., Palma A. M. D., Cinnella G., Mirabella, Lucia, Prattichizzo, Clelia, Castellano G., Di Palma, Anna Maria, Grandaliano G., Gesualdo, Loreto, Sangregorio F., Spadaccino F., Netti G. S., Maiorano A., Godeas G., Crovace, Antonio, Infante, Barbara, Cotoia, Antonella, Mirabella L.   +35 more
core   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source