Results 101 to 110 of about 71,028 (295)

Recombinant CD80 fusion protein combined with discoidin domain receptor 1 inhibitor for cancer treatment

Applied Microbiology and Biotechnology
Immune checkpoint inhibitors (ICIs) have significantly advanced the field of cancer immunotherapy. However, clinical data has shown that many patients have a low response rate or even resistance to immune checkpoint inhibitor alone.
Songna Wang, Pinliang Hu, Xuyao Zhang, Jiajun Fan, Jing Zou, Weidong Hong, Xuan Huang, Danjie Pan, Huaning Chen, Dianwen Ju, Yi Zhun Zhu, Li Ye   +11 more
doaj   +1 more source

FLT3-ITD promotes immune checkpoint CD80 via ROS elevation in acute myeloid leukemia

Frontiers in Immunology
Acute myeloid leukemia (AML), a malignant hematological stem cell disease, arises from the malignant transformation of myeloid progenitor cells. Among the genetic aberrations in AML, mutations in the tyrosine kinase receptor FLT3, especially FLT3-ITD ...
Libo Yan, Weiming Zhang, Qiyan Mo, Daogang Wang, Ning Xu, Mengzhe Yang, Tao Ren   +6 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers

International Journal of Endocrinology, 2018
The dysregulation of PD-1 ligands (PD-L1 and PD-L2) and CTLA-4 ligands (CD80 and CD86) represents a tumor strategy to escape the immune surveillance.
Chiara Tuccilli, Enke Baldini, Salvatore Sorrenti, Antonio Catania, Alessandro Antonelli, Poupak Fallahi, Francesco Tartaglia, Susi Barollo, Caterina Mian, Andrea Palmieri, Giovanni Carbotta, Stefano Arcieri, Daniele Pironi, Massimo Vergine, Massimo Monti, Salvatore Ulisse   +15 more
doaj   +1 more source

Suppression of colon inflammation by CD80 blockade: Evaluation in two murine models of inflammatory bowel disease

, 2008
Background: Human inflammatory bowel disease (IBD) is a chronic condition mediated by aberrant immune responses to the luminal antigens by activated CD4+ T cells.
Summerlin, D (15537056), Srinivasan, M (15537059), Rajaraman Eri (14736106), Kodumudi, N (15537053)   +3 more
core  

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

17p deletion , CD 80 and CD 86 expression in chronic lymphocytic leukemia [PDF]

Minia Journal of Medical Research
Background: In chronic lymphocytic leukemia (CLL), monoclonal B cells proliferate within pseudofollicular proliferation centers. Unlike healthy B cells, leukemic cells are poor antigen-presenting cells due to decreased expression of costimulatory ...
Reem Elgarhy, Aliaa Abd El-Fatah, Nada Sholkamy, Mostafa Elsayed Abuelela, Waleed AbdelHamid, Khaled Salah, Nagwa Okaily   +6 more
doaj   +1 more source

Suppression of immune responses in collagen-induced arthritis by a rationally designed CD80-binding peptide agent

, 2007
Objective. The CD80/CD86-CD28/CD152 costimulatory pathways transmit signals for CD4+ T cell activation and suppression and are critically involved in the pathogenesis of rheumatoid arthritis (RA).
Summerlin, DJ (15537134), Srinivasan, M (15537059), Rajaraman Eri (14736106), Brand, DD (15537137), Zunt, SL (15537131), Blum, JS (15537140)   +5 more
core  

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source