Results 101 to 110 of about 26,169 (207)

Spatiotemporal Transcriptomics Characterizes Immune Microenvironment During Mouse Liver Aging

Aging Cell, Volume 25, Issue 5, May 2026.
T cells are the most dynamically altered immune population in the aged liver. Accumulation of CD8+ Tex in aged livers. Spatial enrichment of CD8+ Tex in the portal vein zone. PP hepatocytes promote T cell exhaustion via Lpin1. T cell exhaustion correlates with liver disease progression.
Jiahua Lu, Yuqian Wang, Wenxue Zhao, Zihao Zhao, Zhaoya Gao, Jin Gu, Cheng Li, Jie Cheng   +7 more
wiley   +1 more source

In vitro and in vivo studies of the immunomodulatory effect of Echinacea purpurea on dendritic cells

Journal of Genetic Engineering and Biotechnology, 2015
Background: Extracts of Echinacea have been used traditionally for the treatment of diverse types of infections and wounds. They have become very familiar immunostimulant herbal medicine. However, the specific immunomodulatory effect of Echinacea remains
N.E. El-Ashmawy, E.A. El-Zamarany, M.L. Salem, H.A. El-Bahrawy, G.M. Al-Ashmawy   +4 more
doaj   +1 more source

Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma [PDF]

, 2006
Background Dendritic cells (DCs) have been used as vaccines in clinical trials of immunotherapy of cancer and other diseases. Nonetheless, progress towards the use of DCs in the clinic has been slow due in part to the absence of standard methods for DC ...
Allred Jacob B, Bulur Peggy A, Padley Douglas J, Butler Greg W, Maas Mary L, Greiner Carl W, Dietz Allan B, Markovic Svetomir N, Creagan Edward T, Ingle James N, Gastineau Dennis A, Vuk-Pavlovic Stanimir   +11 more
core   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Exosomes of Epstein-Barr Virus-Associated Gastric Carcinoma Suppress Dendritic Cell Maturation

Microorganisms, 2020
The Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is characterized by the infiltration of lymphocytes and a unique tumor microenvironment. Exosomes from cancer cells are essential for intercellular communication.
Munetoshi Hinata, Akiko Kunita, Hiroyuki Abe, Yasuyuki Morishita, Kei Sakuma, Hiroharu Yamashita, Yasuyuki Seto, Tetsuo Ushiku, Masashi Fukayama   +8 more
doaj   +1 more source

Mononuclear cell transcriptome changes associated with dimethyl fumarate in MS. [PDF]

, 2018
ObjectiveTo identify short-term changes in gene expression in peripheral blood mononuclear cells (PBMCs) associated with treatment response to dimethyl fumarate (DMF, Tecfidera) in patients with relapsing-remitting MS (RRMS).MethodsBlood samples were ...
Baranzini, Sergio E, Cencioni, Maria T, Gafson, Arie R, Kim, Kicheol, Matthews, Paul M, Nicholas, Richard, van Hecke, Wim   +6 more
core  

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, Volume 13, Issue 19, 2 April 2026.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Expresión de marcadores en células dendríticas de pacientes chagásicos crónicos estimuladas con la proteína KMP-11 y el péptido K1 de Trypanosoma cruzi

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. La proteína de membrana 11 de kinetoplástidos, KMP-11, de Trypanosoma cruzi induce inmunidad humoral y celular en ratones capaz de conferir protección frente al reto con el parásito. Objetivo.
Sandra Paola Santander, Adriana Cuéllar, María del Carmen Thomas, Fanny Guzmán, Alberto Gómez, Manuel Carlos López, Concepción Puerta   +6 more
doaj   +1 more source

Semi Mature Blood Dendritic Cells Exist in Patients with Ductal Pancreatic Adenocarcinoma Owing to Inflammatory Factors Released from the Tumor

, 2010
Background: Much evidence exists regarding the fact that blood DCs, both myeloid DCs (MDCs) and plasmacytoid DCs (PDCs), are negatively affected in different types of cancer, with both reduced numbers and impaired functionality.
Borch, Kurt, Larsson, Marie, Messmer, Davorka, Sandström, Per, Spångeus, Anna, Tjomsland, Vegard   +5 more
core   +1 more source

Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study [PDF]

, 2006
Background: Inflammation is a significant component of atherosclerosis lesions. Bacteria, including periodontopathogens, have been demonstrated in atherosclerotic plaques and cross-reactivity of the immune response to bacterial GroEL with human heat ...
Ford, P. J., Gemmell, E., Carter, C. L., Chan, A., Walker, P. J., Bird, P. S., West, M. J., Cullinan, M. P., Seymour, G. J.   +8 more
core   +2 more sources