Results 161 to 170 of about 448,583 (189)

Immunohistochemical Localization of Antigen Presenting Cells in Liver From Patients With Primary Biliary Cirrhosis; Highly Restricted Distribution of CD83-Positive Activated Dendritic Cells

Pathology Research and Practice, 1999
In order to have insights into the abnormal immune regulation in primary biliary cirrhosis (PBC), different types of antigen presenting cells (APC) were localized immunohistochemically in liver specimens from 26 patients with PBC and compared with the distributions of APC from 11 and 10 patients with chronic hepatitis C (CH-C) and large bile duct ...
Kojiro Michitaka, Sk Md Fazle Akbar, M Onji   +2 more
exaly   +3 more sources

Antigen-Presenting Cells at the Liver Tissue in Patients With Chronic Viral Liver Diseases: CD83-Positive Mature Dendritic Cells at the Vicinity of Focal and Confluent Necrosis

Hepatology Research, 2001
Although defective functions of peripheral blood or splenic antigen-presenting cells (APCs) are implicated in the pathogenesis of persistent infection in murine and human hepatitis B virus (HBV) and hepatitis C virus (HCV)-carriers, little is known regarding liver-infiltrating APCs in patients with chronic liver diseases.
Kojiro Michitaka, Norio Horiike, M Onji
exaly   +3 more sources

4-1BB (CD137) or CD40 Signaling Fails To Improve the Expansion of Antigen Specific T Cells Demonstrated with Engagement of TCR, CD28 and CD83 Ligand.

Blood, 2004
Abstract Following the engagement of the T cell receptor by HLA class I and antigenic peptide, naïve CD8+ T cells are primed to receive one or more costimulatory signals. Some of these signals, which are upregulated on and delivered by mature dendritic cells, include members of the immunoglobulin superfamily such as CD80 and CD83. Using
Naoto Hirano, Marcus O. Butler, Lee M. Nadler   +2 more
openaire   +1 more source

CD83 CAR T overcome CD19 antigen loss in B cell malignancies after CD19-directed therapy

Blood
Abstract Chimeric antigen receptor T cells (CAR T) targeting CD19 can cure approximately a third of patients with aggressive B cell malignancies, but relapse due to CD19 antigen loss and serious infections resulting from B cell aplasia remain major causes of death following CD19 CAR T.
Brian Betts, Constanza Savid-Frontera, Shannon McSain, Kelly Walton, Nolan Beatty, Payal Goala, Shernan Holtan, Meredith Stone, Frederick Locke, Anne Eaton, Michael Linden, Renier Brentjens, Marco Davila   +12 more
openaire   +1 more source

Induction of CD83+ CD14+ non-dendritic antigen-presenting cells by exposure of monocytes to IFN-alpha1

2008
ABSTRACT. Interferon (IFN)-α is a well known agent for treatment of viral and malignant diseases. It has several modes of actions, including direct influence on the immune system. We investigated IFN-α effects on peripheral blood mononuclear cells (PBMC) in terms of dendritic cell (DC) differentiation, as PBMC are exposed to high IFN-α levels during ...
GERLINI, GIANNI, MARIOTTI, GIULIA, CHIARUGI, ALBERTO, P. Di Gennaro, R. Caporale, PARENTI, ASTRID, L. Cavone, A. Tun Kyi, F. Prignano, R. Saccardi, L. Borgognoni, PIMPINELLI, NICOLA   +11 more
openaire   +1 more source

Poster: CT-076: Evaluating CD83 Expression on Organ-Specific Normal Tissues to Anticipate Potential Toxicity of Novel Human CD83-Targeted Chimeric Antigen Receptor (CAR) T-Cell

Clinical Lymphoma Myeloma and Leukemia, 2021
Tony Kurian, Ling Zhang, Bishwas Shrestha, Nelli Bejanyan, Marco Davila   +4 more
openaire   +1 more source

Granulocyte macrophage colony-stimulating factor and interleukin 4 enhance the number and antigen-presenting activity of circulating CD14+ and CD83+ cells in cancer patients.

Cancer research, 2000
Antigen-presenting cells (APCs) are essential for stimulating antigen-specific immunity, including immunity against tumor cells. We hypothesized that systemic administration of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, which promote monocytes to differentiate into dendritic cells in vitro, might enhance the ...
M D, Roth, B J, Gitlitz, S M, Kiertscher, A N, Park, M, Mendenhall, N, Moldawer, R A, Figlin   +6 more
openaire   +1 more source

Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients

Ca-A Cancer Journal for Clinicians, 2022
Sandrine Valadè, Peter Schellongowski, Alexander Shimabukuro-Vornhagen   +2 more
exaly  

Chimeric Antigen Receptor T-Cell Therapy in Multiple Myeloma: A Comprehensive Review of Current Data and Implications for Clinical Practice

Ca-A Cancer Journal for Clinicians, 2023
Sagar Lonial, Rujul Parikh
exaly  

Multi-omic causal analysis pinpoints CD83 as a therapeutic target in asthma acting through antigen-presenting cells

Through a paradigm of systematic causal inference, we have established the immune modulator CD83 not merely as a biomarker, but as a central, druggable driver of asthma, acting by orchestrating a pathogenic antigen-presentation cascade in B cells and dendritic cells.
openaire   +1 more source