Results 171 to 180 of about 15,671 (193)

Antigen-presenting cells at the liver tissue in patients with chronic viral liver diseases: CD83-positive mature dendritic cells at the vicinity of focal and confluent necrosis

Hepatology Research, 2001
Although defective functions of peripheral blood or splenic antigen-presenting cells (APCs) are implicated in the pathogenesis of persistent infection in murine and human hepatitis B virus (HBV) and hepatitis C virus (HCV)-carriers, little is known regarding liver-infiltrating APCs in patients with chronic liver diseases.
M Onji, N Horiike
exaly   +3 more sources

4-1BB (CD137) or CD40 Signaling Fails To Improve the Expansion of Antigen Specific T Cells Demonstrated with Engagement of TCR, CD28 and CD83 Ligand.

Blood, 2004
Abstract Following the engagement of the T cell receptor by HLA class I and antigenic peptide, naïve CD8+ T cells are primed to receive one or more costimulatory signals. Some of these signals, which are upregulated on and delivered by mature dendritic cells, include members of the immunoglobulin superfamily such as CD80 and CD83. Using
Naoto Hirano, Marcus O. Butler, Lee M. Nadler   +2 more
openaire   +1 more source

CD83 CAR T overcome CD19 antigen loss in B cell malignancies after CD19-directed therapy

Blood
Abstract Chimeric antigen receptor T cells (CAR T) targeting CD19 can cure approximately a third of patients with aggressive B cell malignancies, but relapse due to CD19 antigen loss and serious infections resulting from B cell aplasia remain major causes of death following CD19 CAR T.
Brian Betts, Constanza Savid-Frontera, Shannon McSain, Kelly Walton, Nolan Beatty, Payal Goala, Shernan Holtan, Meredith Stone, Frederick Locke, Anne Eaton, Michael Linden, Renier Brentjens, Marco Davila   +12 more
openaire   +1 more source

Induction of CD83+ CD14+ non-dendritic antigen-presenting cells by exposure of monocytes to IFN-alpha1

2008
ABSTRACT. Interferon (IFN)-α is a well known agent for treatment of viral and malignant diseases. It has several modes of actions, including direct influence on the immune system. We investigated IFN-α effects on peripheral blood mononuclear cells (PBMC) in terms of dendritic cell (DC) differentiation, as PBMC are exposed to high IFN-α levels during ...
GERLINI, GIANNI, MARIOTTI, GIULIA, CHIARUGI, ALBERTO, P. Di Gennaro, R. Caporale, PARENTI, ASTRID, L. Cavone, A. Tun Kyi, F. Prignano, R. Saccardi, L. Borgognoni, PIMPINELLI, NICOLA   +11 more
openaire   +1 more source

Poster: CT-076: Evaluating CD83 Expression on Organ-Specific Normal Tissues to Anticipate Potential Toxicity of Novel Human CD83-Targeted Chimeric Antigen Receptor (CAR) T-Cell

Clinical Lymphoma Myeloma and Leukemia, 2021
Tony Kurian, Ling Zhang, Bishwas Shrestha, Nelli Bejanyan, Marco Davila   +4 more
openaire   +1 more source

Granulocyte macrophage colony-stimulating factor and interleukin 4 enhance the number and antigen-presenting activity of circulating CD14+ and CD83+ cells in cancer patients.

Cancer research, 2000
Antigen-presenting cells (APCs) are essential for stimulating antigen-specific immunity, including immunity against tumor cells. We hypothesized that systemic administration of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4, which promote monocytes to differentiate into dendritic cells in vitro, might enhance the ...
M D, Roth, B J, Gitlitz, S M, Kiertscher, A N, Park, M, Mendenhall, N, Moldawer, R A, Figlin   +6 more
openaire   +1 more source

Multi-omic causal analysis pinpoints CD83 as a therapeutic target in asthma acting through antigen-presenting cells

Through a paradigm of systematic causal inference, we have established the immune modulator CD83 not merely as a biomarker, but as a central, druggable driver of asthma, acting by orchestrating a pathogenic antigen-presentation cascade in B cells and dendritic cells.
openaire   +1 more source

Interferon-α Exposure Increases The Number Of Cd83+ Antigen Presenting Cells In Peripheral Blood Mononuclear Cells

Melanoma Research, 2004
G. Gerlini, G. Mariotti, R. Caporale, F. Prignano, R. Saccardi, P. Cappugi, B. Giannotti, N. Pimpinelli   +7 more
openaire   +1 more source

ANTI-CD83 CHIMERIC ANTIGEN RECEPTOR EXPRESSING T REGULATORY CELLS

2021
DAVILA MARCO, BETTS BRIAN
openaire   +1 more source

METHODS OF USING ANTI-CD83 CHIMERIC ANTIGEN RECEPTOR EXPRESSING T CELLS

2022
DAVILA MARCO, BETTS BRIAN
openaire   +1 more source