Results 11 to 20 of about 256,000 (308)
Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. [PDF]
PLoS Pathogens, 2007 CD8(+) T cells are essential for host defense to intracellular bacterial pathogens such as Mycobacterium tuberculosis (Mtb), Salmonella species, and Listeria monocytogenes, yet the repertoire and dominance pattern of human CD8 antigens for these ...
Deborah A Lewinsohn +9 more
doaj +4 more sources
Comprehensive definition of human immunodominant CD8 antigens in tuberculosis. [PDF]
NPJ Vaccines, 2017 AbstractDespite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8+ T cells are critical to tuberculosis host defense and a phase 2b vaccine trial of modified vaccinia Ankara expressing Ag85a that failed to ...
Lewinsohn DA +18 more
europepmc +4 more sources
CD8 memory, immunodominance, and antigenic escape [PDF]
European Journal of Immunology, 2000 Previous theoretical work has suggested that efficient virus control or clearance requires antigen-independent persistence of memory cytotoxic T lymphocyte precursors (CTLp), and that failure to generate such memory CTLp can result in persistent infection and eventual loss of virus control.
D, Wodarz, M A, Nowak
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Signals for antigen-independent differentiation of memory CD8+ T cells [PDF]
Cellular and Molecular Life Sciences, 2021 AbstractConventional CD8+ memory T cells develop upon stimulation with foreign antigen and provide increased protection upon re-challenge. Over the past two decades, new subsets of CD8+ T cells have been identified that acquire memory features independently of antigen exposure.
Eliza Mari Kwesi-Maliepaard +2 more
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Cutting Edge: Antigen-Independent CD8 T Cell Proliferation [PDF]
The Journal of Immunology, 2001 AbstractRecent analyses of CD8 T cell responses to Listeria monocytogenes infection demonstrate that the duration of in vivo T cell proliferation is not determined by the amount or duration of Ag presentation. However, the extent to which T lymphocytes are capable of proliferating in the absence of Ag is unknown.
P, Wong, E G, Pamer
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Antigenic Epitopes Regulate the Phenotype of CD8+ CTL Primed by Exogenous Antigens [PDF]
The Journal of Immunology, 2000 AbstractWe previously reported that insulin-specific, MHC class I-restricted CTL precursors can be primed by injecting C57BL/6 mice with bovine insulin in CFA. These bovine insulin-primed CTL displayed a type 0 CTL phenotype, producing IL-4, IL-5, IL-10, low levels of IFN-γ, but no TNF-α.
H, Ma, J A, Kapp
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Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 To determine the antigenic determinants and specific molecular requirements for the generation of autoregulatory neuroantigen-specific CD8(+) T cells in models of multiple sclerosis (MS).We have previously shown that MOG35-55-specific CD8(+) T cells suppress experimental autoimmune encephalomyelitis (EAE) in the C57BL/6 model.
Ortega, Sterling B. +4 more
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Non-antigen specific CD8+ T suppressor lymphocytes
Clinical and Experimental Medicine, 2004 The homeostasis of peripheral immune system function is maintained by the activity of regulatory lymphocytes. Among these cells, a subset of CD8+CD28- T suppressor lymphocytes has recently been characterized for the capacity to mediate their effects without antigen restriction.
FILACI, GILBERTO +6 more
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Bacterial superantigens reactivate antigen-specific CD8+ memory T cells [PDF]
International Immunology, 1997 Superantigens stimulate naive CD4+ and CD8+ T cells in a TCR V beta-specific manner. However, it has been reported that memory T cells are unresponsive to superantigen stimulation. In this study, we show that staphylococcal enterotoxins (SE) can activate influenza virus-specific CD8+ memory cytotoxic T cells.
M A, Coppola, M A, Blackman
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Antigens for CD4 and CD8 T Cells in Tuberculosis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2014 Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4(+) and CD8(+) T cells play an important role in host defense to TB.
Cecilia S, Lindestam Arlehamn +3 more
openaire +2 more sources