Human natural killer cell committed thymocytes and their relation to the T cell lineage. [PDF]
, 1993 Recent studies have demonstrated that mature natural killer (NK) cells can be grown from human triple negative (TN; CD3-, CD4-, CD8-) thymocytes, suggesting that a common NK/T cell precursor exists within the thymus that can give rise to both NK cells ...
Lanier, LL +3 more
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Tissue signatures influence the activation of intrahepatic CD8+ T cells against malaria sporozoites
Frontiers in Microbiology, 2014 Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-Class I antigen-processing pathway. After the introduction of Plasmodium sporozoites by Anopheles mosquitoes, bone marrow-derived dendritic cells in skin-draining lymph
Alexandre eMorrot +1 more
doaj +1 more source
Hyperpigmentation as a peculiar presentation of mycosis fungoides [PDF]
Anais Brasileiros de Dermatologia, 2017 Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry.
Ying-Yi Lu +3 more
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Cd8 T‐cell recognition of human 5T4 oncofetal antigen [PDF]
International Journal of Cancer, 2006 AbstractThe 5T4 oncofetal antigen is expressed by a wide variety of human carcinomas, including colorectal, ovarian and gastric carcinomas. The restricted expression of 5T4 on tumor tissues as well as its implication in tumor progression and bad prognosis makes 5T4 a promising new candidate for immunotherapy.
Lucy J C, Smyth +13 more
openaire +2 more sources
The combination of CDX2 expression status and tumor-infiltrating lymphocyte density as a prognostic factor in adjuvant FOLFOX-treated patients with stage III colorectal cancers [PDF]
Journal of Pathology and Translational MedicineBackground Colorectal carcinomas (CRCs) with caudal-type homeobox 2 (CDX2) loss are recognized to pursue an aggressive behavior but tend to be accompanied by a high density of tumor-infiltrating lymphocytes (TILs).
Ji-Ae Lee +8 more
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QuilA-adjuvanted T. gondii lysate antigens trigger robust antibody and IFNγ+ T cell responses in pigs leading to reduction in parasite DNA in tissues upon challenge infection [PDF]
, 2019 Toxoplasma gondii is an intracellular parasite of all mammals and birds, responsible for toxoplasmosis. In healthy individuals T. gondii infections mostly remain asymptomatic, however this parasite causes severe morbidity and mortality in ...
Cox, Eric +6 more
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Profiling the Targets of Protective CD8+ T Cell Responses to Infection
Molecular Therapy: Methods & Clinical Development, 2017 T cells are critical effectors of host immunity that target intracellular pathogens, such as the causative agents of HIV, tuberculosis, and malaria.
Joseph T. Bruder +13 more
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Cell Reports, 2023 Summary: Following viral infection, the human immune system generates CD8+ T cell responses to virus antigens that differ in specificity, abundance, and phenotype.
Florian Schmidt +13 more
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Improved induction of anti-melanoma T cells by adenovirus-5/3 fiber modification to target human DCs [PDF]
, 2018 To mount a strong anti-tumor immune response, non T cell inflamed (cold) tumors may require combination treatment encompassing vaccine strategies preceding checkpoint inhibition.
Chondronasiou, Dafni +9 more
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Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
Frontiers in Immunology, 2018 Dendritic cells (DCs) play a central role in the regulation of the balance between CD8 T cell immunity vs. tolerance to tumor antigens. Cross-priming, a process which DCs activate CD8 T cells by cross-presenting exogenous antigens, plays a critical role ...
Chunmei Fu, Aimin Jiang
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