Results 121 to 130 of about 378,605 (167)
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Seminars in Immunology, 2004
This review describes what is generally known about CD8 immune responses, and focus in the most recent advances in this domain. It also attempts to point to the areas where experimental evidence is contradictory or insufficient, and thus require further exploration and clarification.
B, Rocha, C, Tanchot
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This review describes what is generally known about CD8 immune responses, and focus in the most recent advances in this domain. It also attempts to point to the areas where experimental evidence is contradictory or insufficient, and thus require further exploration and clarification.
B, Rocha, C, Tanchot
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Science Immunology, 2023
Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.
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Iterative acute stimulations can maintain CD8 T cells for longer than their organismal lifespan.
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Current Opinion in Immunology, 2005
Mounting evidence shows that CD8(+) T cells contribute to the initiation, progression and regulation of several pathogenic autoimmune responses in which these cells were not previously thought to play a major role. CD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines ...
Ulrich, Walter, Pere, Santamaria
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Mounting evidence shows that CD8(+) T cells contribute to the initiation, progression and regulation of several pathogenic autoimmune responses in which these cells were not previously thought to play a major role. CD8(+) T cells can kill target cells directly, by recognizing peptide-MHC complexes on target cells, or indirectly, by secreting cytokines ...
Ulrich, Walter, Pere, Santamaria
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CD8+ suppressor T cells resurrected
Human Immunology, 2008This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppressor/regulatory T cells, from initial indications that such cells were CD8(+), to the view that such cells
Judith A, Kapp, R Pat, Bucy
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Critical Reviews in Immunology, 2003
Aging of the immune system, or "immunosenescence," is associated with both a marked reduction in responsiveness as well as functional dysregulation. These changes have been implicated in the increased morbidity and mortality of the elderly population from infectious disease, and may also play a role in autoimmunity and cancer.
Rita B, Effros +2 more
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Aging of the immune system, or "immunosenescence," is associated with both a marked reduction in responsiveness as well as functional dysregulation. These changes have been implicated in the increased morbidity and mortality of the elderly population from infectious disease, and may also play a role in autoimmunity and cancer.
Rita B, Effros +2 more
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Seminars in Immunopathology, 2019
CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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CD8+ T cells are important for the protective immunity against intracellular pathogens and tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent antigen and/or inflammatory signals. This excessive amount of signals often leads CD8+ T cells to gradual deterioration of T cell function, a state called "exhaustion ...
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CD8+ T cell-coccidia interactions
Parasitology Today, 1994Host responses to coccidian parasites involve many facets of the immune system, including antigen-specific as well as antigen-nonspecific components. Hyun Lillehoj and James Trout here review the evidence that cell-mediated responses are probably the main line of defense against coccidial infection.
H S, Lillehoj, J M, Trout
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Antimetastatic defense by CD8+ T cells
Trends in Cancer, 2022Metastasis is an intricate process whereby tumor cells migrate from the primary tumor, survive in the circulation, seed distal organs, and proliferate to create metastatic foci. CD8+ T cells can detect and eliminate tumor cells. Research on CD8+ T cell-dependent antitumor immunity has classically focused on its role in the primary tumor.
Tallón de Lara, Paulino +3 more
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Quantitating CD8+ T cell memory development
Trends in Immunology, 2023In acute immune responses to infection, memory T cells develop that can spawn recall responses. This process has not been observable directly in vivo. Here we highlight the utility of mathematical inference to derive quantitatively testable models of mammalian CD8+ T cell memory development from complex experimental data.
Tamar Nizharadze +2 more
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