Results 41 to 50 of about 42,229 (197)

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

Cells, 2022
Study of the initial steps of the CD95-mediated signaling pathways is a field of intense research and a long list of actors has been described in the literature.
Gael Galli, Pierre Vacher, Bernhard Ryffel, Patrick Blanco, Patrick Legembre   +4 more
doaj   +1 more source

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway. [PDF]

PLoS ONE, 2011
Interleukin-7 (IL-7) concentrations are increased in the blood of CD4+ T cell depleted individuals, including HIV-1 infected patients. High IL-7 levels might stimulate T cell activation and, as we have shown earlier, IL-7 can prime resting T cell to CD95
Stefano Sammicheli, Vu Phuong Linh Dang, Nicolas Ruffin, Hong Thang Pham, Rebecka Lantto, Nancy Vivar, Francesca Chiodi, Bence Rethi   +7 more
doaj   +1 more source

Rectal Microbiome Composition Correlates with Humoral Immunity to HIV-1 in Vaccinated Rhesus Macaques. [PDF]

, 2019
The microbiome is an integral and dynamic component of the host and is emerging as a critical determinant of immune responses; however, its influence on vaccine immunogenicity is largely not well understood.
Dinasarapu, Ashok R, Durbin-Johnson, Blythe P, Elizaldi, Sonny R, Iyer, Smita S, Kozlowski, Pamela A, Raeman, Reben, Rolston, Matthew, Settles, Matthew, Verma, Anil, Walter, Korey A   +9 more
core   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of TCE‐secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Erratum: The role of CD95 and CD95 ligand in cancer [PDF]

Cell Death & Differentiation, 2015
Correction to: Cell Death and Differentiation (2015) 22, 549–559; doi:10.1038/cdd.2015.3; published online 6 February 2015 Since the publication of this article the authors have noted that they have inadvertently failed to list an important paper in the field in Table 2. This work (Kleber et al.) has now been added to the revised Table 2 shown below.
M E Peter, A Hadji, A E Murmann, S Brockway, W Putzbach, A Pattanayak, P Ceppi   +6 more
openaire   +1 more source

Age-related changes of apoptotic cell death in human lymphocytes [PDF]

, 2006
Apoptosis seems to be involved in immunosenescence associated with aging. Moreover, in lymphocytes (PBL) of patients with Alzheimer's disease, an increased susceptibility to the apoptotic pathway has been described possibly due to impaired protection of ...
Eckert, Anne, Leutner, Silke, Müller, Walter E., Schindowski, Katharina   +3 more
core  

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Tumor promoting effects of CD95 signaling in chemoresistant cells

Molecular Cancer, 2010
Background CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of CD95 expression in colon cancer ...
Almendro Vanessa, Gascón Pedro, Pastor-Arroyo Eva, Carbó Neus, Fernández-Nogueira Patricia, Costamagna Domizziana, Mayordomo Cristina, García-Recio Susana, Ametller Elisabet   +8 more
doaj   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

The Velocity Distribution of the Nearest Interstellar Gas

, 2002
The bulk flow velocity for the cluster of interstellar cloudlets within about 30 pc of the Sun is determined from optical and ultraviolet absorption line data, after omitting from the sample stars with circumstellar disks or variable emission lines and ...
Berkhuijsen E. M., Berkhuijsen E. M., Bertin P., Blaauw A., Bzowski M., Crawford I. A., Crawford I. A., Crawford I. A., Daniel E. Welty, de Geus E. J., Ferlet R., Ferlet R., Frisch P. C., Haslam C. G. T., Hebrard G., Lallement R., Lallement R., Lallement R., Lallement R., Lauren Grodnicki, Porri A., Priscilla C. Frisch, Weller C. S.   +22 more
core   +1 more source