Results 71 to 80 of about 42,229 (197)

High Expression of Fas/CD95 on CD4+ Circulating T Cells: An Exclusion Criterion in the Diagnosis of Mycosis Fungoides?

Acta Dermato-Venereologica, 2017
The aim of this 10-year monocentric prospective study was to determine a cut-off value of Fas/CD95 expression by peripheral blood CD4+ T lymphocytes in discriminating patients with mycosis fungoides from controls with cutaneous benign lymphocytic ...
Aurélie Du-Thanh, Pierre Portalès, Anne Serre-Cousiné, Céline Girard, Bernard Guillot, Olivier Dereure   +5 more
doaj   +1 more source

A Novel Subset of CD95+ Pro-Inflammatory Macrophages Overcome miR155 Deficiency and May Serve as a Switch From Metabolically Healthy Obesity to Metabolically Unhealthy Obesity

Frontiers in Immunology, 2021
Metabolically healthy obesity (MHO) accounts for roughly 35% of all obese patients. There is no clear consensus that has been reached on whether MHO is a stable condition or merely a transitory period between metabolically healthy lean and metabolically ...
Candice Johnson, Charles Drummer IV, Huimin Shan, Huimin Shan, Ying Shao, Yu Sun, Yifan Lu, Fatma Saaoud, Keman Xu, Gayani Nanayakkara, Pu Fang, Zsolt Bagi, Xiaohua Jiang, Xiaohua Jiang, Eric T. Choi, Hong Wang, Hong Wang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang   +20 more
doaj   +1 more source

Transcriptome–Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass‐Specific Phenotypes

European Journal of Immunology, Volume 56, Issue 3, March 2026.
We performed combined proteome and transcriptome analysis of human isotype‐defined B cell subsets. IgG4‐switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4‐switched B cells.
Jana Koers, Arie J. Hoogendijk, Simon Tol, Floris P.J. Van Alphen, Ninotska I.L. Derksen, Maartje van den Biggelaar, Theo Rispens   +6 more
wiley   +1 more source

Apoptotic markers in CD34-positive cells in acute leukemias

Клиническая онкогематология, 2013
Objective. To evaluate expression of Bcl-2, Bax, p53, CD95, and ACE on CD34+ cells of peripheral blood and bone marrow during induction chemotherapy in the patients with newly diagnosed acute leukemia. Materials and methods.
Ye. N. Parovichnikova, Ye. Ye. Khodunova, I. V. Galtseva, S. М. Kulikov, V. V. Troitskaya, L. А. Kuzmina, D. V. Shcheblyakov, V. G. Savchenko   +7 more
doaj   +1 more source

Heterogeneous Activated B Cell Compartments Arising Early and Transiently After SARS‐CoV‐2 Vaccination

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Characterization of the early antigen‐specific B cell response post‐SARS‐CoV‐2 vaccination reveals novel activated B cell clusters, showing different phenotypes and contraction dynamics. Some short‐lived activated B cells expressed both CD71 and the extrafollicular marker CD11c.
Laura Fernandez Blanco, Lisan H. Kuijper, Laura Y.L. Kummer, Niels J.M. Verstegen, Amélie Bos, Mathieu Claireaux, Mariël C. Duurland, Tineke Jorritsma, Maurice Steenhuis, Gius Kerster, Juan J. Garcia Vallejo, Marit J. van Gils, Koos P.J. van Dam, Eileen W. Stalman, Luuk Wieske, Laura Boekel, Gertjan J. Wolbink, Sander W. Tas, Theo Rispens, Taco W. Kuijpers, Filip Eftimov, Anja ten Brinke, S. Marieke van Ham, of T2B! Immunity Against SARS‐CoV‐2 Study Group   +23 more
wiley   +1 more source

Design and experimental validation of the action of small molecule-based inhibitors of the FADD protein

Вавиловский журнал генетики и селекции, 2016
CD95 is one of the best studied members of the death receptor family. Activation of CD95 leads to the induction of the cell death programme, apoptosis, via formation of the death-inducing signaling complex (DISC).
N. V. Ivanisenko, L. Hillert, V. A. Ivanisenko, I. N. Lavrik   +3 more
doaj   +1 more source

Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines [PDF]

, 2012
Background Fas expression and Fas-induced apoptosis are mechanisms attributed to the selective destruction of cells of the corpus luteum (CL) during luteal regression.
Birt, Alyssa, Duncan, Alice, Forcina, Jennifer, Townson, David H.   +3 more
core   +2 more sources

CD4‐Based Chimeric Antigen Receptor (CAR)‐T Cells With Resistance to HIV‐1 Infection and Enhanced Anti‐HIV Efficacy: Covalent Interaction Between CD4‐CAR and HIV‐1 Envelope Glycoprotein

Journal of Medical Virology, Volume 98, Issue 3, March 2026.
ABSTRACT The current highly active antiretroviral therapy (HAART or ART) effectively suppresses de novo HIV‐1 infection but fails to eliminate HIV reservoir cells, which leads to rapid viral rebound upon ART cessation. Chimeric antigen receptor (CAR) T cells engineered to target HIV‐1 Env⁺ cells offer a promising strategy to eliminate or control these ...
Yaoxian Lou, Xiuting He, Guangming Li, Martin Sikhondze, Jianping Ma, Hongwei Du, Xin Ouyang, Gianpietro Dotti, Mohammad Sajadi, Lishan Su   +9 more
wiley   +1 more source

Immunogenetic characteristics of LADA

Сахарный диабет, 2011
Latent autoimmune diabetes of adults (LADA) is a variant of autoimmune diabetes mellitus. Its clinical feature not typical for classical DM1 despitethe presence of positive autoantibodies is characterized by the low rate of autoimmune destruction that ...
Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Svetlana Mikhailovna Stepanova, Yulia Vladimirovna Tishina, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin   +7 more
doaj   +1 more source

Expression of the CXCR4 S338X Variant Improves Anti‐Leukemia Efficacy of Anti‐CD19 CAR‐T Cells

Cancer Science, Volume 117, Issue 3, Page 613-630, March 2026.
Under normal conditions, CXCL12 stimulation induces CXCR4 degradation. In contrast, CAR19‐T cells expressing the CXCR4 S338X variant maintain receptor stability and sustain ERK and AKT signaling, which supports T‐cell effector function, migration, and survival. Therefore, the enhanced anti‐leukemic activity is conferred by CXCR4 S338X expression in CAR‐
Yushu Mao, Xiaodan Wang, Chun‐Hui Jin, Zhifeng Wei, Qinghao Ding, Ke‐Ke Zhang, Bo‐Wen Dong, Kai‐Wen Zheng, Yufei Hou, Tao Zhang, Wen‐Jie Zhao, Zheng Hu, Yong‐Guang Yang   +12 more
wiley   +1 more source