Serum Concentration of Soluble Decoy Receptor 3 in Glioma Patients Before and After Surgery
Kaohsiung Journal of Medical Sciences, 2004 The suppression of immune responses in malignant gliomas is thought to be involved in glioma pathogenesis. The newly identified tumor-secreted soluble decoy receptor 3 (DcR3) can bind to the ligands CD95L and LIGHT, thereby neutralizing their pro ...
Shiuh-Lin Hwang +6 more
doaj +1 more source
The pathogenesis of oral lichen planus [PDF]
, 2002 Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation by basal keratinocytes and antigen-specific keratinocyte killing by CD8 ...
Bigby, M. +7 more
core +1 more source
Method to Measure Sphingomyelin Synthase Activity Changes in Response to CD95L
, 2017 Sphingomyelin synthases 1 and 2 convert the anti-oncometabolite ceramide to sphingomyelin, the most abundant sphingolipid in plasma membrane. CD95L-induced ceramide increase is associated with the caspase-dependent inhibition of sphingomyelin synthesis, which enhances the mitochondrial route to apoptosis.
Bilal, Fatima +6 more
openaire +3 more sources
Neuronal influence behind the central nervous system regulation of the immune cells
Frontiers in Integrative Neuroscience, 2013 Central nervous system has a highly specialized microenvironment, and despite being initially considered an immune privileged site, this immune status is far from absolute because it varies with age and brain topography.
ANAHI eCHAVARRIA, Graciela eCárdenas
doaj +1 more source
Apoptosis Within Spontaneously Accepted Mouse Liver Allografts: Evidence for Deletion of Cytotoxic T Cells and Implications for Tolerance Induction [PDF]
, 1997 MHC-mismatched liver grafts are accepted spontaneously between many mouse strains. The underlying mechanism(s) is unclear. In the B10 (H2b) to C3H (H2k) strain combination used in this study, donor T cells within the liver were rapidly replaced within 2 ...
Fu, F +7 more
core
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
Nature Communications, 2018 TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli +19 more
doaj +1 more source
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
Cell Reports, 2017 Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited by ...
Abdul S. Qadir +17 more
doaj +1 more source
Relevance of death receptors in nervous system: role in the pathogenesis of neurodegenerative diseases and targets for therapy [PDF]
, 2008 L'apoptosi és un procés fisiològic que controla el nombre de cèl·lules en organismes superiors. L'apoptosi està estrictament regulada i s'ha vist que està implicada en la patogènesi d'algunes malalties del sistema nerviós.
Comella, Joan Xavier, Segura, Miguel F.
core +1 more source
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis. [PDF]
, 2019 BACKGROUND: Unrestrained activation of Th1 and Th17 cells is associated with the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
Chai, Zhi +12 more
core +1 more source
EGFR: A Master Piece in G1/S Phase Transition of Liver Regeneration [PDF]
, 2012 Unraveling the molecular clues of liver proliferation has become conceivable thanks to the model of two-third hepatectomy. The synchronicity and the well-scheduled aspect of this process allow scientists to slowly decipher this mystery.
Alexandra Collin de l'Hortet +2 more
core +1 more source