Results 91 to 100 of about 3,939 (188)

Foxp3-Mediated Suppression of CD95L Expression Confers Resistance to Activation-Induced Cell Death in Regulatory T Cells [PDF]

, 2011
CD4+CD25++Foxp3+ regulatory T cells (Tregs) control self-reactive cells to maintain peripheral tolerance. Treg homeostasis has to be controlled tightly to ensure balanced Treg-mediated suppression.
Vobis, Diana, Andreas Ludwig, Weiss, Eva-Maria, Angelika Schmidt, Ludwig, Andreas, Mayer, Christian T., Elisabeth Suri-Payer, Peter H. Krammer, Garbi, Natalio, Suri-Payer, Elisabeth, Schmidt, Angelika, Krammer, Peter H., Sparwasser, Tim, Katharina Lahl, Eva-Maria Weiss, Diana Vobis, Oberle, Nina, Nina Oberle, Natalio Garbi, Tim Sparwasser, Lahl, Katharina, Christian T. Mayer   +21 more
core   +1 more source

Nitric oxide inhibits apoptosis via AP-1-dependent CD95L transactivation

, 2000
Several inducers of cytotoxic stress promote apoptotic cell death, which, at least in some cases, involves the CD95/CD95 ligand (CD95L) pathway. The induction of the CD95/CD95L pathway can be activated by the activator protein-1 (AP-1)-mediated up ...
Catani MV, Vilbois F, CORAZZARI, MARCO, Bernassola F, Sabatini S, Melino G, Rossi A, Green DR   +7 more
core   +1 more source

Hippocampal myelin damage contributes to cognitive impairment in a rat model of trigeminal neuropathic pain: Neuroprotective and anti-inflammatory effects of atorvastatin

Neuroscience Research
Chronic neuropathic pain is increasingly recognized to impair cognitive function, yet its underlying mechanisms remain unclear. This study tested whether trigeminal neuropathic pain (TNP) modeled by distal infraorbital nerve chronic constriction injury ...
Yongkui Yang, Youzhi Ning, Shuangchun Peng, Changli Liao, Jia Fu, Jiaomei Zhao, Cehua Ou, Yue Zhang   +7 more
doaj   +1 more source

Serum Concentration of Soluble Decoy Receptor 3 in Glioma Patients Before and After Surgery

Kaohsiung Journal of Medical Sciences, 2004
The suppression of immune responses in malignant gliomas is thought to be involved in glioma pathogenesis. The newly identified tumor-secreted soluble decoy receptor 3 (DcR3) can bind to the ligands CD95L and LIGHT, thereby neutralizing their pro ...
Shiuh-Lin Hwang, Chih-Lung Lin, Chi-Yun Cheng, Frank Art Lin, Ann-Shung Lieu, Shen-Long Howng, Kung-Shing Lee   +6 more
doaj   +1 more source

Neuronal influence behind the central nervous system regulation of the immune cells

Frontiers in Integrative Neuroscience, 2013
Central nervous system has a highly specialized microenvironment, and despite being initially considered an immune privileged site, this immune status is far from absolute because it varies with age and brain topography.
ANAHI eCHAVARRIA, Graciela eCárdenas
doaj   +1 more source

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis

, 2012
International audienceCeramide, a biologically active sphingolipid in cell death signaling, accumulates upon CD95L treatment, concomitantly to apoptosis induction in Jurkat leukemia T cells. Herein, we show that ceramide did not increase in caspase-8 and
Schulze-Osthoff, Klaus, Okazaki, Toshiro, Hervé Benoist, Thierry Levade, Elodie Lafont, Nathalie Andrieu-Abadie, Lafont, Elodie, Bruno Ségui, Toshiro Okazaki, Dupont, Romain, Andrieu-Abadie, Nathalie, Benoist, Hervé, Romain Dupont, Levade, Thierry, Klaus Schulze-Osthoff, Ségui, Bruno   +15 more
core   +1 more source

LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L

Nature Communications, 2018
TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal ...
Lucia Taraborrelli, Nieves Peltzer, Antonella Montinaro, Sebastian Kupka, Eva Rieser, Torsten Hartwig, Aida Sarr, Maurice Darding, Peter Draber, Tobias L. Haas, Ayse Akarca, Teresa Marafioti, Manolis Pasparakis, John Bertin, Peter J. Gough, Philippe Bouillet, Andreas Strasser, Martin Leverkus, John Silke, Henning Walczak   +19 more
doaj   +1 more source

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

Cell Reports, 2017
Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited by ...
Abdul S. Qadir, Paolo Ceppi, Sonia Brockway, Calvin Law, Liang Mu, Nikolai N. Khodarev, Jung Kim, Jonathan C. Zhao, William Putzbach, Andrea E. Murmann, Zhuo Chen, Wenjing Chen, Xia Liu, Arthur R. Salomon, Huiping Liu, Ralph R. Weichselbaum, Jindan Yu, Marcus E. Peter   +17 more
doaj   +1 more source

Influence of culture medium pH on cytotoxicity of CD95L in vitro.

Folia histochemica et cytobiologica, 2001
CD95L belongs to the tumor necrosis factor-alpha (TNF-alpha) family, the members of which induce apoptosis by activation of their specific receptors. However, there are a few publications suggesting that two of these factors, TNF-alpha and TNF-beta, are able to reveal cytotoxic effect in pH-dependent manner. Therefore we investigated, whether CD95L may
Tomasz Grzela, Maciej Łazarczyk, Monika Julita Ołdak, Grażyna Korczak-Kowalska   +3 more
openaire   +1 more source

CD95L Inhibition: a novel approach to combat inflammation driven progression of pancreatic ductal adenocarcinoma [PDF]

, 2015
The CD95/CD95L system plays an important role in various biological processes, including cell homeostasis and immunological, neurological and oncological diseases.
Rashid, Khalid
core   +1 more source